Asian Journal of Pharmaceutical Research and Health Care

M. Srinu , G. V. Phani Bhushan , Feleke Moges , J. Srilakshmi , G. Sankar , T. Prabhakar , K. Lakshminarayana

Abstract

The objective of the present study was screening of 3-hydroxy-3- methyl glutaryl Co A (HMG Co A) reductase inhibitor producing marine actinomycetes. A total of 65 morphologically different actinomycetes were screened for HMG Co A reductase inhibitor production in a two stage submerged fermentation and evaluated for HMG CoA reductase inhibitor activity by agar diffusion and thin layer chromatography technique using lovostatin as a control. Among 65 marine Actinomycete strains, only one strain produced HMG Co A reductase inhibitor.

Keywords

Lovastatin, Marine Actinomycetes, HMG Co A Reductase Inhibitor.

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