Asian Journal of Pharmaceutical Research and Health Care

Duraisamy Gomathi , Ganesan Ravikumar , Manokaran Kalaiselvi , Kanakasabapathi Devaki , Chandrasekar Uma

Abstract

The present study investigated the possible therapeutic effects of the whole plant ethanolic extract of Evolvulus alsinoides on oral glucose tolerance test and the membrane bound enzyme activity in streptozotocin induced diabetes rats. The antidiabetic effect of ethanolic extract of Evolvulus alsinodes were studied at different concentrations like 50 mg, 150 mg and 300 mg/kg body weight in streptozotocin induced diabetic rats for 14 days . In that 150 mg/kg dosage showed significant reduction in blood glucose. Hence further studies were carried out by using the dosage of 150 mg/kg. The effects of an ethanol extract of Evolvulus alsinoides on the activities of marker enzymes were also examined in the l iver and kidney tissues. Decreased levels of Sodium potassium , magnesium ATPases were observed in streptozotocin induced diabetic rats whereas calcium ATPase was increased in diabetic rats. A dministration of plant extract to diabetic rats for 45 days restored all membrane bound enzyme activities as to that of control rats and there is no significant difference were found between control and plant extract alone groups. It might be related in part to the modification of fatty acid content during diabetes. Thus the ethanolic extract of Evolvulus alsinoides may alleviate liver and renal damage associated with streptozotocin induced diabetes mellitus in rats.

Keywords

Streptozotocin, Evolvulus Alsinoides, Membrane Bound Enzymes, Diabetes Mellitus.

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