Asian Journal of Pharmaceutical Research and Health Care

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Evaluation of Lactate and Lactate Clearance as a Marker of Outcome in Trauma ICU


Affiliations
1 Department of Anesthesiology, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
2 Department of General Surgery, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
3 Department of Anesthesiology & Critical Care Medicine, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
4 Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
 

Hypo-perfusion is usual in patients suffering from traumatic injury that may be indicated by serum lactate elevation. This study was performed to analyze the relation of the lactate value with trauma mortality and its clearance. The research included a total of 202 trauma patients admitted into ICU. Study parameters such as patient demography, injury mechanism, Blood Pressure (BP), heart rate (HR), Glasgow Coma Scale (GCS) and level of lactate in the blood. All these parameters were documented in the first 3 hours of hospitalization, and lactate clearance was recorded between 3 and 9 hours afterwards. For the study point; death up to 7 days was considered as a direct impact of trauma and considered in study. The study was divided into two subgroups, either expired (n=79) or survivors (n=123) according to the final outcome. The mean age, mean body weight, sex ratio, HR, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in both groups were comparable. The difference in lactate at admission, lactate at 6 hours and lactate clearance in between survivors and deaths were found to be insignificant statistically. Among trauma patients there is no significant relationship between lactate admission or lactate clearance and mortality. Higher sample size may be appropriate for definitive proof to be reached.


Keywords

Clearance, ICU, Lactate, Mortality, Trauma.
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  • Evaluation of Lactate and Lactate Clearance as a Marker of Outcome in Trauma ICU

Abstract Views: 332  |  PDF Views: 157

Authors

Manjaree Mishra
Department of Anesthesiology, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
Mohammad Zeeshan Hakim
Department of General Surgery, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
Shashi Prakash Mishra
Department of General Surgery, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
Shobhit Saxena
Department of Anesthesiology & Critical Care Medicine, Trauma and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India
Nitesh Trivedi
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221005, UP, India

Abstract


Hypo-perfusion is usual in patients suffering from traumatic injury that may be indicated by serum lactate elevation. This study was performed to analyze the relation of the lactate value with trauma mortality and its clearance. The research included a total of 202 trauma patients admitted into ICU. Study parameters such as patient demography, injury mechanism, Blood Pressure (BP), heart rate (HR), Glasgow Coma Scale (GCS) and level of lactate in the blood. All these parameters were documented in the first 3 hours of hospitalization, and lactate clearance was recorded between 3 and 9 hours afterwards. For the study point; death up to 7 days was considered as a direct impact of trauma and considered in study. The study was divided into two subgroups, either expired (n=79) or survivors (n=123) according to the final outcome. The mean age, mean body weight, sex ratio, HR, Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in both groups were comparable. The difference in lactate at admission, lactate at 6 hours and lactate clearance in between survivors and deaths were found to be insignificant statistically. Among trauma patients there is no significant relationship between lactate admission or lactate clearance and mortality. Higher sample size may be appropriate for definitive proof to be reached.


Keywords


Clearance, ICU, Lactate, Mortality, Trauma.

References





DOI: https://doi.org/10.18311/ajprhc%2F2020%2F25642