Asian Journal of Pharmaceutical Research and Health Care

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Nebivolol1 chemically [1-(6-fluorochroman-2-yl)-{[2-(6-fluorochroman-2-yl)-2- hydroxy- ethyl] amino} ethanol)] is a long acting cardio selective beta -blocker currently used for the treatment of hypertension. A sensitive and precise RP-HPLC method has been developed and validated for the determination of Nebivolol in dosage forms. The drug was chromatographed on a C-18 column using a mixture of water and Methanol in the ratio (40:6 0) as mobile phase at a flow rate of 1.0 ml/min. Chlorzoxazone was used as an internal standa rd and detection was done at 282 nm. Linearity range is found to be 5-100 μg/ml with a corre lation coefficient 0.9999 .The mean recoveries obtained for Nebivolol range from 99.6-100.8%. Due to its simplicity, rapidness, high precision and accuracy the proposed method may be used for determining Nebivolol in bulk and dosage forms.

Keywords

Nebivolol, RP-HPLC.
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