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Lata, T.
- Antimicrobial Activity of Crude Extracts of Heliotropium marifolium Retz.
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Journal of Natural Remedies, Vol 3, No 2 (2003), Pagination: 208-211Abstract
Objective: To investigate the antimicrobial activity of different extracts (chloroform, ethylacetate, methanol, water) of the plant. Heliotropium marifolium Retz. Methods: Antimicrobial activity was assessed by standard dilution test using Mueller Hinton agar (MH) medium. The zone of inhibition of the extracts was compared with that of ciprofloxacin (5 μg / disc) by disc diffusion method. Results: The findings showed potential antimicrobial properties of the extracts against the organisms tested. The minimum inhibitory concentration (MIC) of the extracts was 133.33 μg/ml. The zone of inhibition of all extracts was comparable with that of ciprofloxacin. Conclusions: The study suggests that the plant is promising for development of phytomedicine for antimicrobial properties.Keywords
Heliotropium marifolium Retz, Extracts, Antimicrobial Activity, CiprofloxacinFull Text
- Anti-bacterial and Anti-fungal Activities of Ethyl Acetate Extract and the Isolated Fraction of Acanthospermum hispidum DC
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PDF Views:591
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 190-194Abstract
Objective: To examine the anti-bacterial and anti-fungal activities of ethyl acetate extract and the isolated fraction of the plant Acanthospermum hispidum DC. Method: Anti-bacterial activity was studied by agar dilution method using Muller Hinton(MH) Agar media. And the MIC of the extract was compared with that of standard ciprofloxacin (5µg/ml). Anti-fungal activity of the extract was investigated by tube dilution method using Sabouraud Dextrose Agar (SDA) medium and the results compared with standard clotrimazole(125µg/ml). An attempt was made to isolate the fraction responsible for the anti microbial property of the extract. Result: The ethyl acetate extract showed potential anti-bacterial and anti-fungal properties comparable with standard ciprofloxacin and clotrimazole respectively against the organisms examined. The minimum inhibitory concentration (MIC) of the extract for anti-bacterial activity was 200µg/ml. The isolated fraction was also found to possess anti microbial properties similar to that of the crude extract. The MIC of the fraction was 133.33µg /ml. And the thin layer chromatographic study of the fraction showed it as diterpene. Conclusion: The plant appears to be promising for isolation of active constituent for development of phytomedicine for anti-microbial properties.Keywords
Acanthospermum hispidum DC, Ethyl Acetate Extract, Anti-microbial Activity, Ciprofloxacin, Clotrimazole.Full Text