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Krishnaveni, M.
- Influence of Lead on Biochemicals and Proline Contents of Vigna unguiculata (L.) Walp
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Authors
Affiliations
1 Department of Botany, Government Arts College, TIRUVANNAMALAI (T.N.), IN
2 Department of Botany, Annamalai University, Annamalai Nagar, CHIDHAMBARAM (T.N.), IN
1 Department of Botany, Government Arts College, TIRUVANNAMALAI (T.N.), IN
2 Department of Botany, Annamalai University, Annamalai Nagar, CHIDHAMBARAM (T.N.), IN
Source
International Journal of Plant Sciences, Vol 10, No 2 (2015), Pagination: 142-151Abstract
Among heavy metals, lead is an element that is easily accumulated in soil and sediments. The level of lead found in plants is often correlated with the level present in the environment. Cowpea [Vigna unguiculata (L.) Walp.], a member of Fabaceae, it is an annual multi-purpose grain legume plants suitable in a variety of cropping systems. The present study on ecophysiological effect of lead is undertaken to analyse the influence of ead on biochemicals and proline contents of cowpea [Vigna unguiculata (L.) Walp.]. In this study, Co -1 was considered to be more tolerant than other varieties tested. The lead treatment up to 10mg kg -1 soil concentration was, however, beneficial for the overall growth parameters. From those treatments under lead values were increased at 10mg kg-1 lead treatment. The uptake and accumulation of lead in cowpea plants increased with increased of lead level in the soil under field / pot culture experiments. From 25-200mg kg-1 biochemical contents were decreased (except proline).Keywords
Influence, Biochemicals, Proline, Vigna unguiculata.- Therapeutic Efficacy of Phyllanthus emblica L. Fruit Extract and Cisplatin Combination against 7, 12-Dimethylbenz(a)Anthracene Induced Hamster Buccal Pouch Carcinogenesis
Abstract Views :577 |
PDF Views:436
Authors
Affiliations
1 Annamalai University, Annamalainagar – 608 002, Tamil Nadu, IN
1 Annamalai University, Annamalainagar – 608 002, Tamil Nadu, IN
Source
FoodSci: Indian Journal of Research in Food Science and Nutrition, Vol 3, No 1 (2016), Pagination: 1-9Abstract
Amla fruit has been conventionally used as a health food for the prevention and therapy of cancer. Accordingly, the study aimed to explore the chemotherapeutic efficacy of amla and cisplatin combination on molecular mechanistic apoptosis implicated in proliferation, apoptosis and angiogenesis moleules during DMBA-induced buccal pouch carcinogenesis. Our western blot results showed that up regulation of Bcl-2, cyclin D1, Proliferating cell nuclear antigen, Cdc25C, Cox-2, Vascular endothelial growth factor and Survivin were observed in DMBA treated groups, whereas after treatment with combination therapy significantly down regulated the above noted proteins expression level. It was also observed that combination of amla and cisplatin treated tumor groups induced increased levels of Bax, caspase-3 and caspase-9 levels. More intriguingly, the effect was more pronounced in the tumor animals receiving combination therapy suggesting a synergistic effect. The results clearly suggest that combination therapy of amla and cisplatin had inhibitory effect during oral carcinogenesis via induction of apoptosis and suppression of molecules involved in cell proliferation and angiogenesis. Thus, amla fruit contains novel rich source of natural antioxidants and can be considered as an adjuvant therapeutic agent with cisplatin for oral cancer.Keywords
Angiogenesis, Apoptosis, Buccal Pouch Cancer, Chemotherapy, Phyllanthus emblica, Proliferation.References
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