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Wahyuni, Tri
- Effects of Metformin on High-Fat Diet-Induced Hyperlipidemic Rats
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1 Laboratory of Pharmacology and Toxicology, Universitas Indonesia, Kampus UI Depok, 16424, ID
1 Laboratory of Pharmacology and Toxicology, Universitas Indonesia, Kampus UI Depok, 16424, ID
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 26, No 1&2 (2019), Pagination: 1-7Abstract
Metformin as insulin sensitizer is now often associated with a significant decrease in plasma triglycerides, plasma total cholesterol, LDL cholesterol, and a significant increase in plasma HDL cholesterol without causing hypoglycemia. Current research aim are to determine the effects of metformin on high-fat diet-induced hyperlipidemic rats. To this end, a total of 30 Sprague-Dawley rats were divided into six groups (N = 5). Normal control was not treated, the negative group was given 0.5% CMC, the positive group used simvastatin dose of 1.8 mg/kg BW/day orally and three variation dose groups of metformin were given at a dose of 225; 450; and 900 mg/kg BW rat/day orally. Induction was carried out for 28 days and continued for 14 days treated with an administration orally. Lipid profile was measured by the colorimetric enzymatic method. As a result, all doses of metformin significantly decreased total cholesterol and LDL (p <0.05) compared to normal and negative controls. The highest dose significantly decreased triglyceride levels (p <0.05) and increased HDL levels (p <0.05) compared to normal and negative controls. Based on these results, metformin has a potential effect of antihyperlipidemic at a dose of 225 mg/kg BW rat.Keywords
Cholesterol, High-Fat Diet, Hyperlipidemic, Metformin, Triglyceride.References
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- Allopurinol Reduced Oleic Acid Plasma on High-fat Diet-induced Hypertensive Rats
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok – 16424, ID
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok – 1642, ID
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok – 16424, ID
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok – 1642, ID
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 27, No 1&2 (2020), Pagination: 7-13Abstract
Hypertension is still a big challenge and is a key risk factor for cardiovascular disease which is the leading cause of death in the world. We evaluate the effects of Allopurinol in high-fat diet-induced hypertensiverats. To this end we induced hypertension of SD rats by high fat-diet for six weeks and divided into 6 groups (n = 5), for six weeks and one group was fed standard chow. Drugs were given for seven days orally; one group was only given a high-fat diet and CMC 0.5%, as Negative Control; one group was given a high-fat diet and Isosorbide Dinitrate (ISDN) 18 mg/kg as Positive Control, three groups were given a high-fat diet and Allopurinol with dose range of 45-180 mg/kg. Systolic, diastolic, mean arterial pressure and blood glucose were compared between diet groups and normal group; Free Fatty Acid Plasma and Amino Acid Plasma were determined by GC-MS. As a results, Allopurinol significantly reduced blood pressure in all three dose groups (p<0.05). The dose group of Allopurinol and ISDN gave similar results in lowering blood pressure and glucose levels which measured on the last day of drug administration. Allupurinol also reduced oleic acid plasma compared with high-fat diet group. In conclusion, Allopurinol has a potential as an antihypertensive agent by modulating linoleic acid.Keywords
Allopurinol, Blood Pressure, High-fat Diet, Hypertension, Linoleic AcidReferences
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