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Bhaskar, Shreaya
- In Silico Studies and Histopathological Analysis on the Bioremediation Effect of Spirulina in Various Tissues of Diclofenac Treated Pangasius Sps
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Authors
K. S. Shreenidhi
1,
Saranya Sri Santhanam
1,
Shreaya Bhaskar
1,
Sowmia Narayan Sridhar
1,
B. Vijaya Geetha
1
Affiliations
1 Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, IN
1 Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 28, No 3 (2021), Pagination: 239-244Abstract
The aquatic biome is an integral part of Earth’s survival. Humans, with an attitude to lead a comfortable life, have invaded the ecosystem to a larger extent owing to many direct and indirect catastrophes in the longer run. Our aim was to establish the link between the genes and compounds that turn toxic to the organisms over due course of time. With the selected compound as diclofenac, Comparative Toxicogenomics database was used to identify the diseases related to the compounds, the top expressing genes, and the common genes of the compounds. By incorporating the coalescence of spirulina bioremediation under histopathological studies, the effect of the algae was observed. From these two studies, we were able to conclude that there was a significant link between the effects of the compound on the organisms.Keywords
Diseases, Remediation, Spirulina, Toxicity
References
- Roy K, Kar S. In silico models for ecotoxicity of pharmaceuticals. Methods. Mol Biol. 2016; 1425:237– 304. http://dx.doi.org/10.1007/978-1-4939-3609-0_12
- Severtsova EA, Severtsov AS. Comparison of variability of Rana temporaria (Amphibia, anura) gastrula from different populations developing under the conditions of antropogenic pollution. Russ. J Dev Biol. 2005; 36:82–93. https://doi.org/10.1007/s11174-005-0015-9
- Padmini E, Vijayageetha B. Seasonal influences on water quality parameters and pollution status of the Ennore estuary, Tamil Nadu, India. J Environ Hydrol. 2015; 15: 1–9.
- Patneedi CB, Prasadu KD. Impact of pharmaceutical wastes on human life and environment. Rasayan J Chem. 2015; 8(1):67–70.
- Santos LH, Araújo AN, Fachini A, Pena A, Delerue- Matos C, Montenegro MC. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater. 2010; 175(1–3):45–95. https://doi.org/10.1016/j.jhazmat.2009.10.100
- Desai K, Brott D, Hu X, Christianson A. A systems biology approach for detecting toxicity-related hotspots inside protein interaction networks. J Bioinform Comput Biol. 2011; 9:647–62. http://dx.doi.org/10.1109/HISB.2011.61.
- Geetha BV, Sujata KR, Shreenidhi S, Sundararaman TR. Histopathological and HPLC analysis in the hepatic tissue of Pangasius sp. exposed to Diclofena. Pol J Environ Stud. 2018; 27(6):2493–8. http://dx.doi.org/10.15244/pjoes/75829
- Hardy T, Oakley F, Anstee QM, Day CP. Nonalcoholic fatty liver disease: Pathogenesis and disease spectrum. Annu Rev Pathol. 2016; 11:451–96. https://doi.org/10.1146/annurev-pathol-012615-044224
- Skuratovskaya EN, Kovyrshina TB, Rudneva II. A comparative study of long-term pollution effects of marine waters on the blood biomarkers of two benthic fish species: The scorpion fish Scorpaena porcus (Linnaeus, 1758) and the round goby Neogobius melanostomus (Pallas, 1814) from the Black Sea. Russ. J Mar Biol. 2017; 43:232–8. https://doi.org/10.1134/S1063074017030105
- Shafeek F, Abu-Elsaad N, El-Karef A, Ibrahim T. Gum Acacia mitigates diclofenac nephrotoxicity by targeting monocyte chemoattractant protein-1, complement receptor-1 and pro-apoptotic pathways. Food Chem Toxicol. 2019; 129:162–8. https://doi.org/10.1016/j.fct.2019.04.050
- Ryu B, Kim CY, Oh H, Kim U, Kim J, Jung C, Lee B, Lee S, Chang S, Lee JM, Chung H, Park J. Development of an alternative zebrafish model for drug‐induced intestinal toxicity. J Appl Toxicol. 2018; 38:259–73. https://doi.org/10.1002/jat.3520
- Hirashima R, Itoh T, Tukey RH, Ryoichi F. Prediction of drug‐induced liver injury using keratinocytes. J Appl Toxicol. 2017; 37:863–72. https://doi.org/10.1002/jat.3435
- Chang X, He H, Zhu L, Gao J, Wei T, Ma Z, Yan Y. Protective effect of apigenin on Freund’s complete adjuvant-induced arthritis in rats via inhibiting P2X7/ NF-κB pathway. Chem Biol Interact. 2015; 236:41–6. https://doi.org/10.1016/j.cbi.2015.04.021
- Shi F, Zhou D, Ji Z, Xu Z, Yang H. Anti-arthritic activity of luteolin in Freund’s complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway. Chem Biol Interact. 2015; 226:82–7. https://doi.org/10.1016/j.cbi.2014.10.031
- Kim S, Kiyosawa N, Burgoon LD, Chang CC, Zacharewski TR. PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. J. Steroid Biochem Mol Biol. 2013; 138:236–47. https://doi.org/10.1016/j.jsbmb.2013.06.004
- Geetha BV, Shreenidhi KS, Sundararaman TR. A study on the oxidative stress status of Pangasius sp. exposed to phenol and clofibrate. Zeichen Journal. 2021; 7(1):23–32.
- Baba E. Antibacterial effects of seven essential plant oils on fish pathogens. Bol Inst Pesca. 2020; 46(3). https://doi.org/10.20950/1678-2305.2020.46.3.565.
- Aissaoui S, Ouled-Haddar H, Sifour M, Beggah C, Benhamada, F. Biological removal of the mixed pharmaceuticals: diclofenac, ibuprofen, and sulfamethoxazole using a bacterial consortium. Iran J Biotechnol. 2017; 15(2):135–42. https://doi.org/10.15171/ijb.1530
- Al-Ahmad MM, Amir N, Dhanasekaran S, John A, Abdulrazzaq Y, Ali RB, Salema M. Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. PLoS ONE. 2017; 12:1–13. https://doi.org/10.1371/journal.pone.0183424