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Authors
Affiliations
1 Regional Research Institute of Unani Medicine, University of Kashmir Campus, Srinagar 190 006 JK, IN
2 Department of Biochemistry, University of Kashmir Campus, Srinagar 190 006 JK, IN
3 Central Council for Research in Unani Medicine, New Delhi, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 16, No 2 (2009), Pagination: 107-110
Abstract
Capsule Hudar, a very effective compound formulation of Unani System of Medicine, contains Azraqi (Strychnos nux vomica) a deadly poison as one of its constituents. However, it (Strychnos nux vomica) is detoxified, using a classical crude method, before its use to prepare the drug. Results on the evaluation of the drug at dose rate of 5 mg/kg body weight, orally as aqueous extract for 60 days in either sex for its toxicity in Wistar albino rats (150 ± 10g body weight) did not show any significant change in the blood glucose, blood urea and blood urea nitrogen and serum albumin and proteins levels. The activities of GOT/GPT and ACP/ALP levels in serum, brain, kidney, liver and spleen were also not significantly different when compared to controls.
Keywords
capsule hudar, detoxification, strychnine,strychnos nux vomica, Unani herbal formulation
