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Sharma, S. K.
- Safety Assessment of Lincomycin Following Repeated Intramuscular Administration in Goats
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1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004, IN
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004, IN
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 92-95Abstract
A safety evaluation of lincomycin was carried out to assess clinical impact of intramuscular administration of lincomycin on various haematological and biochemical parameters in goats to establish safety profile of lincomycin. Six healthy female goats were treated with single intramuscular dose of lincomycin @10.0 mg/kg body weight. The blood samples were collected at day 0 (before administration of drugs), and on 6th day of drug administration. The hematological and plasma biochemical analysis were done. No significant alterations (p < 0.05) were found in the mean value of haematological and biochemical parameters during treatment period except for significant elevation in values of Lactate dehydrogenase and Creatinine. Repeated intramuscular administration of lincomycin (10.0 mg/kg) for 5 days in goat was found safe. Thus, lincomycin may be useful to treat bacterial diseases accompanied by fever, pain and other inflammatory condition in goats.Keywords
Goats, Lincomycin, Safety Assessment.
References
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- Bhavsar SK, Verma MP, Thaker AM. Pharmacokinetics, tissue concentration, and safety of multiple dose intravenous administration of ciprofloxacin in cow calves. J Vet Pharmacol Toxicol. 2004; 3(1):27–34.
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- Safety Assessment of Marbofloxacin Following Repeated Intramuscular Administration in Goats
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Authors
Affiliations
1 Dept. of Vety. Pharmacology and Toxicology, GADVASU, Ludhiana, Punjab, IN
2 Dept. of Vety. Physiology and Biochemistry, COVAS, CSKHPKV, Palampur, H.P, IN
1 Dept. of Vety. Pharmacology and Toxicology, GADVASU, Ludhiana, Punjab, IN
2 Dept. of Vety. Physiology and Biochemistry, COVAS, CSKHPKV, Palampur, H.P, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 288-291Abstract
Marbofloxacin (MB) is an extended spectrum, third generation fluoroquinolone, developed exclusively for the use in veterinary medicine. The safety assessment was done to evaluate the clinical impact of marbofloxacin after repeated intramuscular administration in goats. Safety of drugs is important and changes in serum biochemical and/or hematological markers could provide an early indication of cellular toxicity. The drug was administered at the dose of 2 mg/kg for 5 days by intramuscular route in six healthy, non-lactating Beetal goats, 1.5-2 yrs of age. Haematological (TLC, TEC, Hb, PCV, MCV, MCH and MCHC) and serum biochemical parameters viz. liver function test (LFT) and kidney function test (KFT) (ALT, AST, ALP, GGT, BUN, creatinine, total proteins and albumin) were determined and analyzed to establish the safety profile of marbofloxacin. The hematological and biochemical parameters were found to fluctuate within normal range during treatment period and no significant alterations (p < 0.05) were found in the mean values. The results indicated that intramuscular administration of marbofloxacin in goats at the dose of 2 mg/kg for 5 days seems to be safe.Keywords
Marbofloxacin, Repeated Administration, Safety Assessment, Goats.References
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- Amelioration of Quinalphos-Induced Oxidative Stress by Emblica officinalis Fruit Extracts in Rats
Abstract Views :312 |
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Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, CSKHPKV, Palampur, IN
2 Department of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana, IN
3 Department of Veterinary Pathology, GADVASU, Ludhiana, IN
1 Department of Veterinary Pharmacology and Toxicology, CSKHPKV, Palampur, IN
2 Department of Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana, IN
3 Department of Veterinary Pathology, GADVASU, Ludhiana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 301-308Abstract
The fruit of Emblica officinalis (commonly known Amla) contain potent antioxidants and is most commonly used in the Ayurveda for the treatment of various diseases. Quinalphos- a organophorus insecticide is known to alter antioxidant defense system in mammals. With this premise, experiment was planned with objective to study the effect of amla fruit extract supplementation on quinalphos induced oxidative stress. Twenty-four Sprague-Dawley rats were homogenously divided into six groups of four animals each. Group I was kept as control. Group II was orally given quinalphos at the dose rate of 2 mg.kg-1. day-1. Group III and V were orally gavaged with amla in sugar and honey bases respectively at the dose rate of 50 μg.kg-1.day-1 whereas group IV and VI were orally dosed with quinalphos along with amla in sugar and honey bases respectively at above mentioned dose rates from day 16-45. The various indices of antioxidant status were analyzed in major organs of treatment groups viz. Liver, kidney and brain. Sub chronic quinalphos administration produced oxidative stress in rats as evidenced by increase in lipid peroxidation, glutathione peroxidase and decline in superoxide dismutase. Oral supplementation of amla extract in sugar and honey bases provided partially amelioration against altered antioxidant status following sub chronic quinalphos exposure. Results of histopathological study were also in corroboration with blood antioxidant status validating amla in either bases was unable to provide full protection against quinalphos induced toxicity in rats.References
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