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Yadav, Neeru
- Safety Assessment of Cefquinome Following Multiple Intramuscular Administration Regarding Haematology of Cow Calves
Abstract Views :409 |
PDF Views:1
Authors
Neetu Rajput
1,
Neeru Yadav
1
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Mhow, Nanaji Deshmukh Veterinary Science University, Jabalpur (M.P.), IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Mhow, Nanaji Deshmukh Veterinary Science University, Jabalpur (M.P.), IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 2 (2017), Pagination: 167-170Abstract
The present study was carried out to investigate haematological alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg-1 body weight in five healthy male cow calves. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1st, 2nd, 3rd, 4th, 5th and 6th from jugular vein into Ethylene Diaminetetraacetic Acid Tripotassium Salt (K3EDTA) coated vacutainers for haematological parameters (Hemoglobin, Packed cell volume, total leukocyte count and differential leukocyte count) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic doses produced non-significant difference (p<0.05) in values of haematological parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in haematological parameters following intramuscular administration, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.Keywords
Cefquinome, Cow Calves, Safety Study, Cephalosporin, Antibiotic.
References
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- Kadota T, Kondoh H, Chikazawa H, Kuroyanagi, K, Ishikawa K, Kawano S, Sakakura, K, Takahashi N,Funahashi N and Shimizu N. Cefepime (diHCl/L-arginine blend): intravenous continuous infusion and single dose subcutaneous toxicity study in rats and dogs. Jpn J Antibiot.1992; 45(6):612-9.
- Limbert M, Isert D, Klesel D, Markus A, Seeger K, Seibert G and Schrinner E. Antibacterial activity in-vitro and in-vivo and pharmacokinetics of cefquinome (HR 111V), a new broad spectrum cephalosporin.Antimicrobial Agents and Chemotherapy.1991; 35(1):14-19.
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- Patel PN, Bhavsar SK, Patel UD, Pandey NK and Wadhwani KN. Safety evaluation of cefepimefollowing repeated intravenous administration in sheep.Indian Journal of Field Veterinarians. 2007; 2: 24-29.
- Rana MP. “Studies on effect of tolfenamic acid and bio-enhancertrikatu on pharmacokinetics of cefquinome and safety of simultaneous administration of cefquinome and tolfenamic acid in patanwadi sheep”.2014; M.V.Sc. Thesis. Anand Agricultural University. Gujarat, India.
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- Biochemical Alterations Following Repeated Intramuscular Administration of Cefquinome in Cow Calves during its Safety Assessment
Abstract Views :396 |
PDF Views:1
Authors
Neetu Rajput
1,
Neeru Yadav
1
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Mhow, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Mhow, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 240-243Abstract
The present study was carried out to investigate biochemical alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg-1 body weight in five healthy cow calves during its safety assessment study. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1st, 2nd, 3rd, 4th, 5th and 6th from jugular vein into vacutainers without K3EDTA for serum biochemical parameters (serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), serum alkaline phosphatase (AKP), serum acid phosphatase (ACP) and serum bilirubin) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic dose produced non-significant (p<0.05) difference in values of serum biochemical parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in serum biochemical parameters following intramuscular administration of cefquinome, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.Keywords
Cefquinome, Cow Calves, Safety Study, Cephalosporin, Antibiotic.References
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- Kadota T, Kondoh H, Chikazawa H, Kuroyanagi K, Ishikawa K, Kawano S, Sakakura K, Takahashi N, Funahashi N and Shimizu N. Cefepime (diHCl/L-arginine blend): intravenous continuous infusion and/orsingle dose subcutaneous toxicity study in rats and dogs. Jpn J Antibiot. 1992; 45(6):612-9.
- Kai S, Kohmura H, Ishikawa K, Kawano S, Sakai A, Kuroyanagi K, Kadota T and Takahashi N. Reproductive and developmental toxicity studies on cefepimedihydrochlorideadministered subcutaneously to rats during the premating, gestation and lactation periods. Jpn J Antibiot. 1992; 45(6):642-60.
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- Limbert M, Isert D, Klesel D, Markus A, Seeger K, Seibert G and Schrinner E. Antibacterial activity in-vitro and in-vivo and pharmacokinetics of cefquinome (HR 111V), a new broad spectrum cephalosporin.Antimicrobial Agents and Chemotherapy. 1991; 35(1):14-19.
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- Patel PN, Bhavsar SK, Patel UD, Pandey NK and Wadhwani KN. Safety evaluation of cefepime following repeated intravenous administration in sheep. Indian Journal of Field Veterinarians.2007; 2: 24-29.
- Rana M.P. “Studies on effect of tolfenamic acid and bioenhancertrikatu on pharmacokinetics of cefquinome and safety of simultaneous administration of cefquinome and tolfenamic acid in patanwadi sheep”. 2014; M.V.Sc. Thesis. Anand Agricultural University. Gujarat, India.
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- Tiwari S. Studies on effect of febrile condition and coadministration of meloxicam on pharmacokinetics of cefquinome and its safety in goats.2014; Ph.D. thesis (Pharmacology and toxicology), Navsari Agriculture University, Navsari.