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Dar, Muneer Ahmad
- Effects on Oxidative Balance and Acetlycholinesterase in Liver and Brain of Rats Dermally Exposed to Bifenthrin
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1 Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, IN
1 Department of Veterinary Pharmacology and Toxicology, Shere-e-Kashmir University of Agricultural Sciences and Technology, (SKUAST)-Jammu, R. S. Pura, 181102, J&K, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 244-248Abstract
The present study was aimed to appraise the oxidative stress potential of bifenthrin and its effects on acetylcholinesterase in liver and brain of wistar rats after its repeated dermal application for a period of 30 days. The rats were divided into four groups with six rats in each group. Group I and III served as control and were applied with distilled water @ 1.8ml/Kg/day where as the animals of group II and IV were dermally applied with bifenthrin @ 45mg/Kg/day for 20 and 30 days respectively. Significant increase in MDA levels was observed in liver and brain homogenates after 20th and 30th day of dermal treatment. Significant decrease in SOD was observed both in liver and brain after 20th and 30th day. GPx decreased significantly after 30th day in liver and after 20th and 30th day in brain. The activities of GST and CAT decreased significantly in liver and brain both after 20th and 30th days of dermal application. Non-significant decrease in AchE was observed in liver and brain homogenates.Keywords
Bifenthrin, Liver, Brain, Oxidative Stress, Acetyl-Cholinesterase, Rats.
References
- Kakko I, Toimela T, Tahti H. The synaptosomal membrane bound ATPase as a target for neurotoxic effects of pyrethroids, permethrin and cypermethrin. Chemosphere. 2003; 51: 475-480.
- Pesticide Manual. Tomlin CDS,ed. The Pesticide Manual. London: The British Crop Protection Council. 1997
- Dar MA,Raina R., Mir AH, Sultana M, Pankaj NP. Effect of dermal application of bifenthrin on acetlycholinesterase and oxidative stress indices in rat blood, lung and Kidney. ProcNatlAcadSci India Sect. B Biol Sci. 2014; DOI 10.1007/s40011-014-0390-z
- Yang L, Li L. Actions of the Pyrethroid Insecticide Bifenthrin on Sodium Channels Expressed in Rat Cerebral Cortical Neurons. ToxicolMech Method. 2015; 25:63-69.
- Punareewattana K., Smith BJ, Blaylock BL, Longstreth J, Snodgrass HL, Gogal RM, Prater RM, Holladay SD. Topical permethrin exposure inhibits antibody production and macrophage function in C57B1/6N mice. Food ChemToxicol. 2001; 39: 133.
- Shafiq-ur-Rehman. Lead-induced regional lipid peroxidation in brain. ToxicolLett. 1984; 21(3): 333-337.
- Marklund S, Marklund M. Involvement of superoxide anion radical in auto-oxidation of pyrogallol and a convenient assay of superoxide dismutase. European J Biochem. 1974; 47: 469-474.
- Aebi HE. Catalase. In Methods Enzymatic analysis (ed.HU. Bergmeyer, New York: Academic Press).1983.
- Hafeman DG, Sunde RA, Hoekstra WG. Effect of dietry selenium on erythrocyte and liver glutathione peroxidase in rat. J Nutr. 1974;104; 580-587.
- Habig WH, Pabst MJ, Jakoby WB. Glutathione–S-transferase. The first enzymatic step in mercapturic acid foramtion. J BiolChem. 1974; 249:7130-7139.
- Voss G, Sachsse K.Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by a modified acetylcholine/DTNB procedure. ToxicolAppl Pharm. 1970; 16: 764-842.
- Snedecor GW, Cochran WG. Statistical Methods. (6thed. Ames: Iowa State University Press). 1967.
- Dar MA, Khan AM, Raina R, Verma PK , Sultana M. Effect of repeated oral administration of bifenthrin on lipid peroxidation and anti-oxidant parameters in wistar rats. Bull Environ ContamToxicol. 2013;90: doi.10.1007/s00128-1022-7.
- Khan AM, Sultana M, Raina R., Dubey N, Dar SA. Effect of sub-acute toxicity of bifenthrin on antioxidant status and haematology after the oral exposure in goats. ProcNatlAcadSci India Sect B Biol Sci. 2013: doi:10.1007/s4001-013-0157-y.
- Dar MA, Khan AM,Raina R,Beigh, SA, Sultana M. Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats. Toxicol Environ Chem. 2015; http//dx.doi.org/10.1080/02772248.1070160.
- Raina R, Verma PK, Kusum, Vinay Kant. Effect of repeated dermal application of α-cypermethrin on lipid peroxidation and antioxidant system in rats. Toxicol. Int. 2009;16: 27-30.
- Dubey N, Raina R, Khan AM. Toxic effects of deltamethrin and fluoride on antioxidant parameters in rats. Fluoride. 2012; 45: 242-246.
- Singh AK, Saxena PN, Sharma HN. Stress induced by beta-cyfluthrin, a type-2 pyrethoid, on brain biochemistry of Albino rat (Rattusnorvegicus). Biol med. 2009;1:74.
- Singh AK, Tiwari MN, Upadhyay G. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: Postnatal exposure enhances the susceptibility during adulthood. Neurobiol Aging. 2012; 33: 404-415.
- Rao GV,Rao K S. Modulation in acetylcholinesterase of rat brain by pyrethroids in vivo and an in vitro kinetic Study. J Neurochem. 1995; 65: 2259-2266.
- Shah MAA, Gupta PK P. Influence of permethrina synthetic pyrethoids insecticide on cholinesterase activities in erythrocytes, plasma, brain and liver of rats. Indian J Toxicol. 2001; 8: 169-172
- Piner P, Unerb N. Oxidative and apoptotic effects of lambda-cyhalothrin modulated by piperonylbutoxide in the liver of Oreochromisniloticus. Environ ToxicolPharmacol. 2012; 33:414-420.
- Bond CE and GreenfieldSA. Multiple cascade effects of oxidative stress on Astroglia. Glia. 2007; 55: 1348-1361.