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Yadegari, Maryam
- Evaluation of Toxicity Effects of Asafetida on Biochemical, Hematological, and Histological Parameters in Male Wistar Rats
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Affiliations
1 Department of Physiology, Herbal Medicine Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, IR
2 Department of Anatomy, Shahid Sadoghi University of Medical Sciences, Yazd, IR
3 Neurobiomedical Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, IR
1 Department of Physiology, Herbal Medicine Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, IR
2 Department of Anatomy, Shahid Sadoghi University of Medical Sciences, Yazd, IR
3 Neurobiomedical Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, IR
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 1 (2015), Pagination: 61-65Abstract
Objectives: Asafetida is traditionally used in folklore medicine for the treatment of various ailments. To validate its use in traditional medicine, it is important to evaluate its toxicity in the animal system. Therefore, this study aimed to evaluate the toxicological effects of asafetida in Wistar albino rats. Materials and Methods: Acute toxicity tests were conducted by the oral administration of 250, 500, and 1,000 mg/kg body weight of the animal. In chronic study, animals were administered with various doses of asafetida (25, 50, 100, and 200 mg/kg body weight) for a period of 6 weeks. At end of experiment, the effects of asafetida on hematological, renal, and hepatic markers and histological parameters were analyzed. Results: In acute toxicity study, no mortality was seen up to 72 h of the administration of asafetida. No signs of neurological and behavioral changes were noticed within 24 h. In the chronic study, the asafetida intake has changed the hematological parameters such as red blood cell (RBC), white blood cell (WBC), hematocrit (HCT), and platelets. Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased in treated animals. The plasma level of urea and creatinine were not altered by the administration of asafetida throughout the study. Histopathology study indicates hepatotoxicity, but no signs of prominent pathological changes in kidney. Conclusions: Asafetida did not show any acute toxicity, but chronic administration could have undesirable effects on hepatocytes and hematological factors.Keywords
Asafetida, Hematology, Kidney, Liver, Toxicity.
- Microscopical Evaluation of Healing Effect of Falcaria vulgaris Extract on Aspirin-Induced Gastric Ulcer in Rats
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Authors
Affiliations
1 Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, IR
2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR
3 Department of Anatomical Sciences, Mazandaran University of Medical Sciences, Sari, IR
1 Department of Biology and Anatomical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, IR
2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR
3 Department of Anatomical Sciences, Mazandaran University of Medical Sciences, Sari, IR
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 29-35Abstract
Objectives: Gastroprotective effects of herbal medicine were shown in numerous studies. Falcaria vulgaris (Ghazzayaghi) has traditionally been used for the treatment of stomach disorders in the Northwest of Iran. The present study was carried out to evaluate the microscopic healing effect of F. vulgaris extract on aspirin-induced gastric damage in rats. Materials and Methods: Thirty five young male rats were divided into five groups (7 rats/group). Control (group I) treated with 1 ml/kg distilled water. Four groups of animals had been exposed to starvation for 48 h and then received aspirin (200 mg/kg) in 1 ml carboxymethyl cellulose (CMC) 1% solvent for 3 days. Then, groups II-IV of rats were treated with 150 mg/kg extract (experimental group), 20 mg/kg omeprazole (reference group) and CMC solution (ulcer control group) by gavages for 14 days, respectively. The fifth group only received aspirin for 3 days. Three hours after last treatment rats were sacrificed and the stomachs were fixed in formalin (10%) and sections of 6 μ in diameter were prepared. Ulcer index, curative ratio, and morphological characteristics of the stomach were assessed using hematoxylin and eosin and Van Gieson staining. Data were analyzed using one-way ANOVA and post hoc Tukey test. Results: The results indicated that F. vulgaris extract significantly decreased the ulcer index (P < 0.01), increased curative ratio, and enhanced the formation of collagen fibers compare to aspirin and omeprazole groups. Conclusions: Hydroalcoholic extract of F. vulgaris showed significant microscopic healing effect on the aspirin-induced gastric ulcer.Keywords
Aspirin, Curative Ratio, Falcaria vulgaris, Gastric Ulcer, Hydroalcoholic Extract, Ulcer Index.References
- Patel AB, Shama KP, Shastry CS. Antiulcerogenic activity of Moringa oleifera ischolar_main extract against ethanol-induced gastric ulcer in rats. Int J Pharm Chem Sci. 2012; 1:243–9.
- Watanabe T, Higuchi K, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T. Mechanisms of peptic ulcer recurrence: Role of inflammation. Inflammopharmacology. 2002; 10:291–302.
- Metowogo K, Eklu-Gadegbeku K, Agbonon A, Aklikokou KA, Gbeassor M. Gastroprotective effect of hydroalcoholic extract of Aloe buettneri. Iran J Pharm Res. 2011; 10:69–74.
- Duggan AE, Stack W, Hull M, Filipowicz B, Knifton A, Crome R, et al. Protection against aspirin-induced human gastric mucosal injury by bosentan, a new endothelin-1 receptor antagonist. Aliment Pharmacol Ther. 1999; 13:631–5.
- Khazaei M, Salehi H. Protective effect of Falcaria vulgaris extract on ethanol induced gastric ulcer in rat. Iran J Pharm Ther. 2006; 5:43–6.
- Saha N, Sachdev A, Bhasin DK, Sankaranahyanan A, Khosla PP, Singh K, et al. Clinical evaluation of the effect of omeprazole, cimetidine, famotidine and ranitidine on histamine induced cutaneous wheal and flare response. Int J Clin Pharmacol Ther Toxicol. 1993; 31:322–5.
- Mahmood AA, Mariod AA, Al-Bayaty F, Abdel-Wahab SI. Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats. J Med Plants Res. 2010; 4:685–91.
- Alkofahi A, Atta AH. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats. J Ethnopharmacol. 1999; 67:341–5.
- Azhdari E. Treatment of diseases by traditional method. 4th ed. Mashhad: Yas Publishers; 2001. p. 226–9.
- Mir-Haidar H. Plant knowledge and using plants to prevent and treatment of disease. 1st ed. Office of Islamic culture. 2001. p. 67–8. (In Persian).
- Bazaz BSF, Harrirzadeh G, Imani SA, Rashed MH. Survey of Iranian plants for alkaloid, flavonoids, saponin and tanin. (Khorasan province). Int J Pharmacol. 1993; 35:17–30.
- Khazaei M, Yadeghari M, Ghorbani R. Protective effect of Falcaria vulgaris extract on aspirin- Induced gastric ulcers in rat. Sci J Kurdistan Univ Med Sci. 2006; 11:16–26.
- Vinothapooshan G, Sundar K. Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. Res J Pharm Biol Chem Sci. 2010; 1:606.
- Yadegari M, Khazaei M, Ghorbani R, Rezai M, Izadi B, Sheikholeslam A. Wound healing effect of Falcaria vulgaris leaves on aspirin induced gastric ulcer in rats. Behbood J. 2006; l0:195–203.
- Zeeyauddin K, Narsu ML, Abid M, Ibrahim M. Evaluation of antiulcer activity of Boswellia serrata bark extracts using aspirin induced ulcer model in albino rats. J Med Allied Sci. 2011; 1:14–20.
- Mehraein F, Sarbishegi M, Aslani A. Therapeutic effects of oleuropein on wounded skin in young male BALB/c mice. Wounds. 2014; 26:83–8.
- Pradhan D, Biswasroy P, Singh G, Suri KA. Anti-ulcerogenic activity of ethanolic extract of Cucumis sativus L against NSAID (Aspirin) induced gastric ulcer in wistar albino rats. Int J Herb Med. 2013; 1:115–9.
- Guth PH, Paulsen G, Nagata H. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: Effect of prostaglandin cytoprotection. Gastroenterology. 1984; 87:1083–90.
- Nafeeza MI, Fauzee AM, Kamsiah J, Gapor MT. Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats. Asia Pac J Clin Nutr. 2002; 11:309–13.
- Wallace JL. How do NSAIDs cause ulcer disease? Baillieres Best Pract Res Clin Gastroenterol. 2000; 14:147–59.
- Morton JF. The horse radish tree: M. pterigosperma (Moringacea). A boon to arid lands. Econ Bot. 1999; 45:318–33.
- Verma VK, Singh N, Saxena P, Singh R. Anti-ulcer and antioxidant activity of Moringa Oleifera (Lam) leaves against aspirin and ethanol induced gastric ulcer in rats. Int Res J Pharm. 2012; 2:46–57.
- Ismail IF, Golbabapour S, Hassandarvish P, Hajrezaie M, Abdul Majid N, Kadir FA, et al. Gastroprotective activity of Polygonum chinense aqueous leaf extract on ethanol-induced hemorrhagic mucosal lesions in rats. Evid Based Complement Alternat Med. 2012; 2012:404012.
- Ramirez RO, Roa CC Jr. The gastroprotective effect of tannins extracted from duhat (Syzygium cumini Skeels) bark on HCl/ethanol induced gastric mucosal injury in Sprague-Dawley rats. Clin Hemorheol Microcirc. 2003; 29:253–61.
- Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci. 1987; 32:1395–401.