Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Dash, Jeevan Ranjan
- Safety Evaluation of Nimovet® in Poultry Birds
Abstract Views :1458 |
PDF Views:0
Authors
Jeevan Ranjan Dash
1,
Manas Ranjan Senaparti
2,
Prakash Chandra Behera
2,
Sushen Kumar Panda
3,
Subas Chandra Parija
1
Affiliations
1 Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
2 Department of Veterinary, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
3 Department of Veterinary Pathology Biochemistry, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
1 Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
2 Department of Veterinary, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
3 Department of Veterinary Pathology Biochemistry, College of Veterinary Science & Animal Husbandry, Orissa University of Agricultural Technology, Bhubaneswar, Odisha, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 2 (2016), Pagination: 134-139Abstract
Nimesulide, a NSAID causes toxicity to poultry birds and indirectly to human through residue present in poultry meat. Birds of control and treated group (Gr-C, Gr-50, Gr-100 and Gr-200) received 10% ethanol, 50, 100 and 200 ppm Nimesulide (Nimovet®) in drinking water up to 42 days, respectively. Statistical analysis done by ANOVA and LSD by Turkey's test. No mortality was observed in treated groups. There was progressive and a significant reduction in feed and water intake in birds of Gr-200 at day 21, 28 and 42 as compared to control birds. The % body weight gain was significantly reduced in Gr-50&Gr-100 at 21 day and Gr-200 from 14 to 42 day interval. Urea level was significantly increased in birds of Gr-50 &100 by 1.5 fold and Gr-200 by 2 fold as compared to the birds of Gr-C. The serum ALT, AST and ALP activity was significantly increased in the birds of Gr-200 as compared to birds of Gr-C. Histo-pathological alterations were observed in heart, liver, lungs and kidney leaving brain, intestine, thymus, spleen and bursa intact in the birds of Gr-200 at 42 day interval. Cumulative administration of Nimesulide (Nimovet®) in poultry birds is (i) safe up to 100 ppm for 6 week period and (ii) unsafe with organic toxicity at 200 ppm. In consideration of the present findings it could be predicted that Nimesulide (Nimovet®) at higher dose could cause toxicity to poultry birds itself and ultimate consumers including scavenger birds and animals.Keywords
Nimesulide, Poultry Birds, Toxicity, Safety Evaluation.References
- Machin, K.L., Tellier, L.A., Lair, S., Livingston, A., Pharmacodynamics of flunixin and ketoprofen in mallard ducks (Anas platyrhynchos). J. Zoo. Wildlife Med., 2001, 32, 222-229.
- Canan, S., Aktas, A., Ulkay, M.B., Colakoglu, S., Ragbetli, M.C., Ayyildiz, M., Geuna, S., Kaplan, S., Parentally expose to a non-steroidal anti inflammatory drug or saline solution impairs sciatic nerve morphology- A stereological and histological study. Int. J. Develop. Neurosci., 2008, 26, 733-738.
- Reddy, P.N.C., Anjaneyula, Y., Sivasankari, B., Rao, A.K., Comparative toxicity studies in birds using Nimesulide and diclofenac sodium. Environ. Toxicol. Pharmacol., 2006, 22, 142-147.
- Cuthbert, R., Pain, D.J., Green, R.E., Swan, G., Swarup, D., Comparative toxicity studies of NSAID in birds: A criticism of Reddy et al. Environ. Toxicol. Pharmacol., 2007, 23, 254-255.
- Snedecor, G.W. and Cochran, W.G., Statistical Methods. 7th edn. Iowa State University Press, Iowa, USA, ISBN-10: 0813815606, 1980, p: 507.
- Flecknell, P.A., Orr, H.E., Roughan, J.V., Stewart, R., Comparison of the effects of oral or subcutaneous carprofen or ketoprofen in rats undergoing laparotomy. Vet. Record., 1999, 144, 65-67.
- Marks, H.L. and Pesti, G.M., The role of protein and diet form in water consumption and abdominal fat pad deposition in broilers. Poult. Sci., 1984, 63, 1617-1625.
- Ferket, P.R., Gernat, A.G., Factors That Affect Feed Intake of Meat Birds: A Review. Int. J. Poult. Sci., 2006, 10, 905-911.
- Allen, P.C., Effect of treatments with cyclo-oxygenase inhibitors on chickens infected with Eimeria accervulina. Poultry.Sci., 2000, 79, 1251-1258.
- Swetha, R., Jayakumar, K., Narayanaswamy, H.D., Lokesh, L.V., Muniappan, N., Toxicity study of diclofenac in broiler chickens. Paper presented in Vth Annual Conference of Indian Society of Vet Pharmacol Toxicolo, Chennai, India, November 24th- 26th, 2005, pp 34.
- Lumeij, J.T., Avian plasma chemistry in health and disease. Proc Annu Conf Assoc Avian Vet. 1993, pp: 20-26.
- Lumeij, J.T., Pathophysiology, diagnosis and treatment of renal disorders in birds of prey In: Lumeij JT, Remple, J.D., Redig, P.T., Lierz ,M., Cooper, J.E. (eds). Raptor Biomedicine III, Lake Worth, FL, Zoological Education Network, Inc, 2000, pp 169-178.
- Tripathi, M., Singh, B.K., Mishra, C., Raisuddin, S., Kakkar, P., Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against Nimesulide induced apoptosis in vitro. Toxicol. In Vitro., 2010, 24, 495-508.
- Singh, B.K., Tripathi, M., Pandey, P.K., Kakkar, P., Nimesulide aggravates redox imbalance and calcium dependent mitochondrial permeability transition leading to dysfunction in vitro. Toxicol., 2010, 275, 1-9.
- Boelsterli, U.A., Mechanism of NSAID-induced hepathotoxicity: focus on Nimesulide. Drug. Saf., 2002, 25, 633-648.