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Authors
Affiliations
1 Department of Pathology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 2 (2016), Pagination: 199-201
Abstract
1,4-Dioxane is a cyclic ether with a molecular formula of C4H8O2. It is used as a solvent and degreasing agent in industries like textile, paints, varnishes, oil, dyes etc. Occupational exposure can occur in the industrial workers. Absorption of 1,4-Dioxane usually occurs by inhalation, oral or dermal routes. Exposure to high doses is associated with severe kidney and liver damage. We report a fatal case of acute high dose toxicity of 1,4-Dioxane following occupational exposure. The deceased was exposed to the chemical while washing large industrial tanks containing 1,4-Dioxane. Autopsy examination revealed extensive renal cortical necrosis, centrilobular hepatic necrosis, pulmonary oedema and intra-alveolar haemorrhages. This case had medico-legal implications and a lawsuit was filed by the family of the deceased to get compensation for death due to occupational exposure.
Keywords
1,4-Dioxane, Renal Cortical Necrosis, Centrilobular Hepatic Necrosis.
References
- U.S. Department of Health and Human Services. Hazardous Substances Data Bank. National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
- U.S. Environmental Protection Agency. p-Dioxane Health Advisory. Office of Drinking Water, Washington, DC. 1987.
- Agency for Toxic Substances and DiseaseRegistry (ATSDR). 2012. “Toxicological Profile for 1,4-Dioxane.”
- Young JD, Braun WH, Gehring PJ, et al. 1976. Short Communication. 1,4-dioxane and betahydroxyoxyacetic acid excretion in urine of humans exposed to dioxane vapors. Toxicol Appl Pharmacol 38:643-646.
- Barber H. 1934. Hemorrhagic nephritis and necrosis of the liver from dioxane poisoning. Guys Hosp Rep 84:267-280.
