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Husain, Gulam Mohammed
- 90-days Repeated Oral Dose Toxicity Study on Jawarish Bisbasa (A Polyherbal Unani Formulation)
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Authors
Mohd Urooj
1,
Muskula Anudeep Reddy
1,
Mahe Alam
2,
Munawwar Husain Kazmi
1,
Gulam Mohammed Husain
1
Affiliations
1 Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, IN
2 Central Council for Research in Unani Medicine, New Delhi - 110058, IN
1 Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, IN
2 Central Council for Research in Unani Medicine, New Delhi - 110058, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 4 (2018), Pagination: 224-231Abstract
Jawarish Bisbasa (JBS) is a polyherbal Unani formulation clinically indicated for the treatment of Zof-e-Meda (Stomach Weakness), Zof-e-Hazm (Dyspepsia), Bawaseer Amya (Blind piles), Nafkh-e-Shikam (Flatulence) and Ghasiyan (Nausea). The present study was designed to investigate toxicity of JBS following 90 days repeated oral administration in rats. JBS was orally administered at the dose levels of 1000 and 2000 mg/kg bw/day. The results obtained showed that oral administration of JBS at doses 1000 and 2000 mg/kg bw did not show any significant adverse effects on survival, body weight gain, hematology, clinical biochemistry, gross necropsy and histopathology. Therefore, No-Observed-Adverse-Effect-Level (NOAEL) is found to be greater than 2000 mg/kg body weight.Keywords
Jawarish Bisbasa, Polyherbal, Toxicity, Unani.
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