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Debendranath, Guha Mazumder
- Role of Glutathione-S-Transferase Polymorphism on Arsenic Induced DNA Hypermethylation
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Authors
Chanda Sarmishtha
1,
Dasgupta Uma
2,
Guha Mazumder Debendranath
3,
Chaudhuri Utpal
2,
Ganguli Bhaswati
4
Affiliations
1 Department of Physiology, Presidency College, Kolkata - 700073, West Bengal, IN
2 Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata - 700073, West Bengal, IN
3 Institute of Post Graduate Medical Education and Research, Kolkata - 700020, West Bengal, IN
4 Department of Statistics, University of Calcutta, Kolkata - 700073, West Bengal, IN
1 Department of Physiology, Presidency College, Kolkata - 700073, West Bengal, IN
2 Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata - 700073, West Bengal, IN
3 Institute of Post Graduate Medical Education and Research, Kolkata - 700020, West Bengal, IN
4 Department of Statistics, University of Calcutta, Kolkata - 700073, West Bengal, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 3 (2015), Pagination: 96-100Abstract
People chronically exposed to environmental arsenic through their drinking water experience various arsenic induced clinical manifestations and there is modulation of methylation level in their genome. However the response varies widely among persons. The present manuscript deals with the evaluation of role of individual's GST status in altering the degree of DNA methylation after chronic arsenic exposure in human. To study whether Glutathione-S-Transferase (GST) gene polymorphism plays any role in this variation, a total of 92 study subjects were recruited from the villages of southern region of West Bengal, India. Concentration of arsenic in their urine and water, extent of clinical manifestation, GST status and p53 and p16 gene promoter methylation status were determined. Results showed that genetic polymorphism of GSTM1 and T1 were significantly associated (p<0.05) with degree of methylation in p53 and p16 gene promoter region and urinary arsenic in higher exposure group. Persons having null genotype have significantly decreased urinary arsenic and increased DNA methylation level relative to persons with GSTM1 or GSTT1 nonnull genotype of same arsenic exposure group. In the present work we are therefore trying to show that individual's GST polymorphic status may alter the degree of DNA methylation after arsenic exposure.Keywords
Arsenic, Clinical Symptom Score, DNA Hypermethylation, GST Polymorphism, Total Urinary Arsenic.
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