Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Choudhary, Govind Kumar
- Chronic Toxicity of Indoxacarb and its Amelioration by Rhizome Powder of Hedychium spicatumin WLH Cockerels
Abstract Views :389 |
PDF Views:0
Authors
Affiliations
1 ICAR-KVK, IIVR, Bejwa, Bhadohi, U.P., IN
2 Department of Veterinary Pharmacology & Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, IN
1 ICAR-KVK, IIVR, Bejwa, Bhadohi, U.P., IN
2 Department of Veterinary Pharmacology & Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 2 (2017), Pagination: 203-210Abstract
The objective of the present study was to evaluate the chronic toxicity by determining biochemical parameters after prolong exposure with indoxacarb @ 250 ppm and its amelioration by concurrent administration of rhizome powder of Hydechiumspicatum (HSRP) @ 2000ppm and 4000ppm in feed for 16 weeks in WLH cockerels. The total protein, globulins, albumins and glucose levels in blood serum were significantly (P<0.05) decreased whereas direct bilirubin, indirect bilirubin, BUN, creatinine, ALT, AST, ALP, GGT were significantly (P<0.05) increased in indoxacarb intoxicated cockerels groups indicating hepatotoxic and nephrotoxic effects. Simultaneous administration of HSRP in both 2000ppm and 4000pp min diet produced amelioration in biochemical profile of indoxacarb intoxicated cockerels. Thus, it is concluded that HSRP was effective in restoration of biochemical parameters and revealed hepatoprotective and nephroprotective effects in 16 weeks feeding trial in cockerels.Keywords
Biochemical, Indoxacarb, Hedychium spicatum, WLH Cockerels.
References
- ThapliyalS, Juyal V, Bhandari A. Hepatoprotective and Antioxidant Activity of Methanol Extract of Hedychium spicatum against CCl4-Induced Liver Injury in Rats. Res J Pharmaceutical, Biol. and Chem. Sc.; 2014; 5 (2): 1428.
- Puri A, Srivastava A, Bhardwaj A, Tondon J S, Saxena K C. Journal of Medicinal Plants Research; 2013, 7 (44): 3242-3246.
- Kajaria D, Tripathi J S, Tiwari S K, Pandey B L. In-vitro evaluation of immunomodulatory effect of polyherbal compound – Bharangyadi. Journal of Drug Delivery & Therap.; 2013, 3 (1): 36-39.
- Choudhary G K, Singh S P. Cytotoxic potential of rhizome extracts of Hedychium spicatum L. in HepG2 cell line using MTT, Indian J of Animal Sc.; 2017, 87 (3): 313–315.
- Singh K L, Bagh G C. Phytochemical Analysis and Determination of Total Phenolics Content In Water Extracts of Three Species of Hedychium. Intern J. Pharm. Tech. Res.; CODEN (USA),;2013, 5 (4): 1516-1521.
- Choudhary G K, Singh S P. (2017). Ameliorating potential of Hedychium spicatum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels, Indian J Animal Res; 2017, 51 (5):
- Sravani T, Paarakh P M. Antioxidant property of Hedychium spicatum Buch.-Ham. rhizomes, Ind. J. of Natural Product and Resources; 2012, 3 (3): 354-358.
- Thapliyal S, Juya V, Bhandari A. Pharmacognostic Screening of Hedychium spicatum Rhizomes, Inter J of Pharmaceutical and Chem Sc.; 2014, 3 (4): 483-488.
- Choudhary G K, Singh S P. Ameliorative efficacy of Hedychium spicatum ischolar_main powder in indoxacarb intoxicated WLH cockerels. J. Vet. Parmacol. & Toxicol.; 2016, 15 (2): 61-64.
- Lapied B, Grolleau F, Sattelle D B. Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels, British J Pharmacol.; 2001, 132: 587−595.
- Mudaraddi T Y, Kaliwal B B. Indoxacarb induces testes oxidative stress in Swiss Albino Mice. Inter J Biotech. Res.; 2009, 1: 40-48.
- Mudaraddi T Y, Potadar R R, Kaliwal B B. Indoxacarb induces liver oxidative stress in Swiss Albino Mice, Eur J of Experi Bio.; 2012, 2 (1): 180-186.
- Frame S R. Oncogenicity study with DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127) eighteen-month feeding study in mice. Unpublished report No. HLR 799-96 from DuPont Haskell Laboratory, Newark, Delaware, USA. 1997, Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
- Mertens J J W M. (1997). Subchronic oral toxicity: 90-day study with DPX-JW062-106 (50% DPX-KN128, 50% DPXKN127) feeding study in dogs. Unpublished report No. HLO 494-95, RV3 from WIL Research Laboratories, Inc., Ashland, Ohio, USA. 1997. Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
- Wolf P L, Williams D, Coplon N, Coulson A S. Low aspartate transminase activity in serum of patients undergoing chonichaemolysis. Clin. Chem.; 1972.18:567.
- Moss D W, Henderson A K. Clinical enzymology, In: Tietz Textbook of clinical chemistry, 3rd ed., C. A. Burtis and E. R. Ashwood, Eds. W.B. Saunders, Philadelphia. 1994, pp 617-721.
- Young D S. Effects of drugs on clinical Laboratory tests. Third Edition, AACC Press, 1997, 937 pp.
- Bower L D, Wong E T. Kinetic Serum Creatinine Assays. II. A Critical Evaluation and review, Clin. Chem.; 1980, 26(5):555-561.
- Lowry O H, Rosebrough N J, Farr A L, Randall R J. 1951. Total protein estimation by lowery’s Methods, J. Biol. Chem; 1951, 193: 265.
- Snedecor G W, Cochran W G. Statistical methods, 9th edition. Iowa State University Press, 1994, Ame.
- Malek D E. Subchronic oral toxicity: 90-day study with DPX-JW062 (50% DPX-KN128, 50% DPX-KN127) feeding study in rats. Unpublished report No. HLR 751-93, RV2 from DuPont Haskell Laboratory, Newark, Delaware, USA; 1997, Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
- Robinson M W, Harmon C, O’Farrelly C. Liver immunology and its role in inflammation and homeostasis. Cellular and Mol Immunol.; 2016, 13: 267-276.
- Joshi U, Mishra S H. Preliminary evaluation of immunomodulatory and antistress activity of methanol extract of Hedychium spicatum. Pharmacologyonline, 2009, 1: 1057-1071.
- Westwood A. The analysis of bilirubin in serum. Annals of clinical Biochemistry. 1991, 28 (2): 119.
- Benzamin M M. Outline of Veterinary clinical pathology, ed 3rd Kalyani Publishers, New Delhi. 2010, pp 241-245.
- Guyton A C, Hall J E. Text book of medical physiology, 11th edn. Elsevier saunder, Philadelphia, 2006, pp. 343-344.
- Rosalki S B, Mcintyre N. Biochemical investigations in the management of liver disease. Oxford textbook of clinical hepatology, 2nd ed. New York, Oxford University Press, 1999, pp. 503-521.
- Dufour D R, Lott J A, Nolte F S, Gretch D R, Koff R S. Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis and monitoring. Clin. Chem.; 2001, 47: 1133-1135.
- Amacher D E. A toxicologist’s guide to biomarkers of hepatic response. Hum. Exp. Toxicol.; 2002. 21: 253-262.
- Goyal S, Sandhu H S. Toxic effects of sub-chronic oral exposure of indoxacarb on biochemical parameters in buffalo calves, Toxicol. Int.; 2009, 16 (2): 141-146.
- Goyal S, Sandhu H S. Clinicobiochemical evaluation of Sub-acute toxicity of indoxacarb in buffalo calves. J. Vety. Pharmacol. & Toxicol.; 2014, 13 (1): 63-66.
- Kumar A, Garg U K, Gupta S K, Jatav G P, Rajput Neetu. Effect of indoxacarb induced toxicity on biochemical parameters in broilers (Gallus domesticua). J Vety. Pharmacol. & Toxicol.; 2014, 12 (1-2) : 21-23.
- Rosen H R, Keefe E B. Evaluation of abnormal liver enzymes, use of liver tests and the serology of viral hepatitis: Liver disease, diagnosis and management. 1st edn. New York, Churchill Livingstone Publishers, 2000, pp. 24-35.
- Friedman, S. F., Martin, P. and Munoz, J. S. Laboratory evaluation of the patient with liver disease.Hepatology, a text-book of liver disease.Philedelphia, Saunders Publication, 1 : 661-709.
- Filip R, Lopez P, Giberti G, Coussio J, Ferraro G. Phenolic compounds in seven south American Ilex species. ‘Fitoterapia’ 2001, 72 (7): 774-778.
- Thapa B R, Walia A. Liver function test and their interpretation. Indian J. Pediatr.; 2007, 74: 663-671.
- Gordon T. Factors associated with serum alkaline phosphatase level. Arch. Pathol. Lab. Med., 1993; 117 : 187-193.
- Sibal A, Gopalan S. 2015. Text book of pediatric gastroenterology, hepatology and nutritions. 1st edn.,Jaypee Brothers Medical Publications (P) Ltd. New Delhi, 2015; pp. 301-302.
- Long Term Exposure with Indoxacarb in WLH Cockerels Produces Reproductive Toxicity and its Amelioration by Rhizome Powder of Shati (Hedychium spicatum)
Abstract Views :305 |
PDF Views:0
Authors
Affiliations
1 Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IN
1 Department of Veterinary Pharmacology & Toxicology, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 24, No 3 (2017), Pagination: 269-275Abstract
The toxic effects of indoxacarb on the reproductive organ of cockerel and protective effect of Gandhpalasi (Hedychium spicatum) were evaluated in this study. The dose of indoxacarb was selected on the basis of LD50 in cockerels (250mg/kg). The experimental birds were kept in deep litter system of housing and maintained on grower ration. Birds were sacrificedafter completion of 16 weeks feeding trial. The semen were collected for estimation of mass motility, sperm count and % dead sperm. The antioxidant biomarkers in testis were also estimated. Finally the microscopic and ultrastructure of the testes were seen comparatively in both indoxacarb intoxicated and HSRP treated cockerels. The significant (P<0.05) reduction in sperm count and mass motility in indoxacarb group II and simultaneous treatment with HSRP in group VI and VII showed significant (P<0.05) improvement which was at par with the control. The % dead sperm were increased significantly (P<0.05) in indoxacarb treated group II whereas in HSRP treated group VI and VII showed significant decline in dose dependent manner. The antioxidant biomarker were significantly (P<0.05) changes by indoxacarb intoxication but treatment HSRP produced significant (P<0.05) amelioration. At the time of microscopic and ultrastructure examination of testes showed changes in indoxacarb treated group II and in HSRP treated group VI and VII showed mild to moderate changes. It is concluded from the present study that the HSRP produced protective effect in indoxacarb induced reproductive toxicity and its amelioration by HSRP treatment.Keywords
Indoxacarb, Cockerel, Gandhpalaasi (Hedychium spicatum), Reproductive Toxicity.References
- Lapied B, GrolleauF, Sattelle D B. 2001. Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels British Journal of Pharmacology, 2001.132: 587−595.
- Mudaraddi T Y, Potadar RR, Kaliwal BB. Indoxacarb induces liver oxidative stress in Swiss Albino Mice, European Journal of Experimental Biology, 2012, 2 (1): 180-186.
- Mudaraddi T Y, Kaliwal BB. Indoxacarb induces testes oxidative stress in Swiss Albino Mice. International Journal of Biotechnology Research (IJBR), 2009, 1: 40-48.
- Nassar A M K. Comparative endocrine disrupting effects of abamectin and indoxacarb insecticides. International Journal of Pharmacology & Toxicology, 2016, 4 (1): 89-92.
- Thapliyal S, Juya V, Bhandari A. Pharmacognostic Screening of Hedychium spicatum Rhizomes, International Journal of Pharmaceutical and Chemical Sciences, 2014, 3 (4): 483-488.
- Choudhary G K, Singh S P. Ameliorating potential of Hedychiumspictum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels. Indian J. Anim. Res., 2017, 51 (5): 832-836.
- Choudhary G. K. Singh S. P. Ameliorative efficacy of Hedychium spicatum ischolar_main powder in indoxacarb intoxicated WLH cockerels. J. Vet. Parmacol. &Toxicol, 2016, 15 (2): 61-64.
- Wheeler N C, Andrews F N. The influence of season on semen production in domestic fowl. Poult. Sci., 1943, 22: 261-367.
- Allen C J, Champion L R. Competitive fertilization in the fowl. Poult. Sci., 1955, 34: 1332-1341.
- Rehman S U. Lead induced regional lipid peroxidation in brain. Toxicol. Lett., 1984, 21: 333-337.
- Prins H K, Loos JA. Glutathione, In: Yunis, J.J. ed. Biochemical methods in red cell genetics. New York, Academic Press.1969, pp.115-137.
- Hafeman D G, Sunde R A, Hoekstra W G. Effect of Dietry Selenium on Erythrocyte and Liver GPx in the Rat. J. Nutrition, 1974, pp. 580-587.
- Luna L G. Manual of histologic Staining Methods of the Armed Forces Institute of pathology, 3rd ed. 1968, McGraw-Hill, New York.
- Snedecor G W, Cochran W G. Statistical methods, 9th edition. Iowa State University Press, 1994, Ame.
- Breslin W J. Two generation reproduction/fertility study with DPX-JW062-106 in rats. Unpublished report No. HLO 115-96, RV1 from MPI Research, Mattawan, Michigan, USA. 1997, Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
- Kim J G,Parthasarathy S. Oxidation and Spermatozoa. SeminReprod. Endocrinol.,1998, 16 (4): 235-239.
- Thapliyal S, Juyal V, Bhandari A. Hepatoprotective and Antioxidant Activity of Methanol Extract of Hedychium spicatum against CCl4-Induced Liver Injury in Rats. Res J of Pharmaceutical, Biol. and Chem. Sci., 2014, 5 (2): 1428.
- Singh K L,Bagh GC. Phytochemical Analysis And Determination Of Total Phenolics Content In Water Extracts Of Three Species of Hedychium. Inter Journal of Pharm. Tech. Research, CODEN (USA), 2013, 5 (4): 1516-1521.
- Stoh, S. J. and Bagchi, D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 1995, 18: 321-336.
- Kumar A, Garg U K, Gupta S K, Jatav G P, Rajput Neetu. Effect of indoxacarb induced toxicity on biochemical parameters in broilers (Gallus domesticus). Journal of Vety. Pharmacol. &Toxicol. 2014, 12 (1-2): 21-23.
- G K Choudhary, S P Singh and M Batra. Ameliorative effect of rhizome powder of Gandhpaalasi (Hedychium spicatum) in intoxacarb intoxicated WLH cockerels. The Indian J. Veterinary Research, 2018, 26(2) : 37-41.
- Sravani T,Paarakh P M. Antioxidant property of Hedychium spicatum Buch.-Ham. rhizomes, Ind. J. of Natural Product and Resources, 2012, 3 (3): 354-358.
- Kajaria D, Tripathi J S, Tiwari S K, Pandey B L. In-vitro evaluation of immunomodulatory effect of polyherbal compound – Bharangyadi. Journal of Drug Delivery & Therapeutics, 2013, 3 (1): 36-39.
- Puri A, Srivastava A, Bhardwaj A, Tondon J S,Saxena K C. Immunostimulant activity of certain plants used in Indian traditional medicine, Journal of Medicinal Plants Research. 2013, 7 (44): 3242-3246.