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Abdel Rashid, Eman AM.
- Incidence and Outcome of Aluminium Phosphide Poisoning Cases Admitted to the Egyptian National Poisoning Centre
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Authors
Affiliations
1 Department of Pharmacology, Cairo University, EG
2 National Egyptian Center of Environmental and Toxicological Research (NECTR), Cairo University, EG
1 Department of Pharmacology, Cairo University, EG
2 National Egyptian Center of Environmental and Toxicological Research (NECTR), Cairo University, EG
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 4 (2018), Pagination: 213-223Abstract
Aluminium Phosphide (ALP) poisoning is one of the major causes of suicidal deaths. It is one of the fatal pesticides. It liberates lethal phosphine gas when it comes in contact either with atmospheric moisture or with hydrochloric acid in the stomach. It causes cellular hypoxia, inhibition of cytochrome c oxidase and formation of highly reactive hydroxyl radicals. The aim of this work was to investigate ALP poisoning-related deaths in the National Egyptian Center of Environmental and Toxicological Research (NECTR), to arouse attention to its use in committing suicide due to its easy availability through the objective data from a sample of acutely poisoned patients admitted to NECTR in Cairo. Management of cases is mainly supportive as there is no specific antidote, causing high mortality rate. Early arrival and proper decontamination, resuscitation, intensive monitoring and supportive therapy may result in good outcome.Keywords
Aluminium Phosphide (ALP), Blood Lactate Level, Mortality, Phosphine Gas, Prediction.
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