Toxicology International (Formerly Indian Journal of Toxicology)

Emmanuel Hatzipantelis ¹, Ioannis Kyriakidis ¹, Evangelos Pavlou ¹, Efterpi Pavlidou ¹

Affiliations
1 Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, AHEPA General Hospital, Thessaloniki, GR

Abstract

Vincristine-induced neurotoxicity is an adverse effect commonly seen in pediatric patients treated for cancer. We hereby present a case of a 6-year-old boy with acute lymphoblastic leukemia, who developed bilateral eyelid ptosis 25 days after the last intravenous administration of vincristine (cumulative dose 14.2 mg i.e., 17.75 mg/m^²). The boy was treated with 5 mg/kg thiamine and with 10 mg/kg pyridoxine. Complete recovery of ptosis was noticed 4 weeks after the initiation of Vitamins B1 and B6 supplementation therapy.

Keywords

Neurotoxicity, Ptosis, Vincristine, Vitamin B1, Vitamin B6.

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