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D. Jhala, Devendrasinh
- Melatonin Ameliorates 2,4-dichlorophenoxyacetic Acid Induced Testicular Steroidogenesis Upset In Mice: An In Vivo And In Silico Study
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Authors
Affiliations
1 Reproductive Physiology Laboratory, Department of Zoology, Biomedical Technology and Human Genetics, University School of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
2 GSBTM Sponsored Bioinformatics Nodal Centre, Institute Of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
3 Reproductive Physiology Laboratory, Department Of Zoology, Biomedical Technology And Human Genetics, University School Of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
1 Reproductive Physiology Laboratory, Department of Zoology, Biomedical Technology and Human Genetics, University School of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
2 GSBTM Sponsored Bioinformatics Nodal Centre, Institute Of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
3 Reproductive Physiology Laboratory, Department Of Zoology, Biomedical Technology And Human Genetics, University School Of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 2 (2022), Pagination: 257-274Abstract
2,4-Dichlorophenoxyacetic acid (2,4-D) is used as a selective herbicide and associated with a variety of toxicities in mammals. In contrast, melatonin is an antioxidant that promotes the elimination of free radicals. In the present study, the protective effects of melatonin (10 mg/kg body weight) against 2,4- D (low, mid, and high dose-16.5, 33.0, and 66.0 mg/kg body weight) induced testicular steroidogenesis alteration were examined using in vivo and in silico models. Doses of 2,4-D and melatonin were administered orally for 28 days. The evaluated parameters were body weight, total protein, markers for male reproductive function, and steroidogenesis i.e. testis weight, total lipid, cholesterol, testosterone, 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase, total sperm count, sperm motility, and sperm viability along with the histopathology of the testis. The statistical significant value was considered at p<0.05. Molecular docking study was performed for interaction of 2,4-D and melatonin with steroid binding proteins. In vivo results revealed that 2,4-D treatment showed a significant dose-dependent alteration in above all studied parameters. No significant auto-recovery was observed in the withdrawal study, on the contrarily, the altered parameters were normalized and comparable to control when melatonin was given alone and in combination with 2,4-D. In silico results also demonstrated that the binding affinity of melatonin with steroid binding proteins is higher than 2,4-D. Collectively, these in vivo and in silico findings indicated that 2,4-D induced testicular toxicity accompanied by steroidogenesis upset and can be reduced by melatonin significantly by interacting directly and strongly with studied molecular markers.Keywords
2,4-dichlorophenoxyacetic Acid, Melatonin, Mice, Mitigation, Molecular Docking, Steroidogenesis.References
- Zhang WJ, Jiang FB, Ou JF. Global pesticide consumption and pollution: with China as a focus. Proc Int Acad Ecol Environ Sci. 2011; 1(2):125-44. http://www.iaees.org/publications/journals/piaees/articles/2011-1(2)/6-Zhang-Abstract.asp.
- Peterson MA, McMaster SA, Riechers DE, Skelton J, Stahlman PW. 2,4-D past, present, and future: A review. Weed Technol. 2016; 30(2):303-45. https://doi.org/10.1614/WT-D-15-00131.1.
- Tomlin CD. The pesticide manual: A world compendium British Crop Production Council; 2009.
- Aylward LL, Hays SM. Biomonitoring Equivalents (BE) dossier for 2,4-dichlorophenoxyacetic acid (2,4-D) (CAS No. 94-75-7). Regul Toxicol Pharmacol. 2008; 51(3):S37-48. PMid: 18579270. https://doi.org/10.1016/j.yrtph.2008.05.006.
- Sharma A, Mollier J, Brocklesby RWK, Caves C, Jayasena CN, Minhas S. Endocrine-disrupting chemicals and male reproductive health. Reprod Med Biol. 2020; 19(3):243-53. PMid: 32684823 PMCid: PMC7360961. https://doi.org/10.1002/rmb2.12326.
- Aitken RJ, Baker MA. Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol. 2006; 250(1-2):66-9. PMid: 16412557. https://doi.org/10.1016/j.mce.2005.12.026.
- Jabtonska-Trypuc A, Wotejko E, Wydro U, Butarewicz A. The impact of pesticides on oxidative stress level in human organism and their activity as an endocrine disruptor. J Environ Sci Health B. 2017; 52(7):483-94. PMid: 28541098. https://doi.org/10.1080/03601234.2017.1303322.
- Astiz M, de Catalfo GE, García MN, Galletti SM, Errecalde AL, de Alaniz MJ, et al. Pesticide-induced decrease in rat testicular steroidogenesis is differentially prevented by lipoate and tocopherol. Ecotoxicol Environ Saf. 2013; 91:129-38. PMid: 23465731. https://doi.org/10.1016/j.ecoenv.2013.01.022.
- Marouani N, Tebourbi O, Cherif D, Hallegue D, Yacoubi MT, Sakly M, et al. Effects of oral administration of 2,4-dichlorophenoxyacetic acid (2,4-D) on reproductive parameters in male Wistar rats. Environ Sci Pollut Res Int. 2017; 24(1):519-26. PMid: 27734311. https://doi.org/10.1007/s11356-016-7656-3.
- Tan Z, Zhou J, Chen H, Zou Q, Weng S, Luo T, et al. Toxic effects of 2,4-dichlorophenoxyacetic acid on human sperm function in vitro. J Toxicol Sci. 2016; 41(4):543-9. PMid: 27432240. https://doi.org/10.2131/jts.41.543.
- Penitente-Filho JM, Neves JG, da Matta SL, Torres CA, Chaya AY, de Paula TA. Morphometric evaluation of the spermatogenic process of adults wistar rats exposed to the 2,4-diclorophenoxiacetic acid associated to picloram (TORDON 2,4-D 64/240 BR). Acta Vet Bras. 2014; 8(1):47-53. https://doi.org/10.21708/avb.2014.8.1.3544.
- Joshi SC, Tibrewal PR, Sharma AK, Sharma PR. Evaluation of toxic effect of 2,4-D (2,4-dichlorophenoxyacetic acid) on fertility and biochemical parameters of male reproductive system of albino rats. Int J Pharm Pharm Sci. 2012; 4(3):338-42. https://innovareacademics.in/journal/ijpps/Vol4Suppl3/3757.pdf.
- Mi Y, Zhang C, Taya K. Quercetin protects spermatogonial cells from 2,4-d-induced oxidative damage in embryonic chickens. J Reprod Dev. 2007; 53(4):749-54. PMid: 17389777. https://doi.org/10.1262/jrd.19001.
- Zhang D, Wu Y, Yuan Y, Liu W, Kuang H, Yang J, et al. Exposure to 2,4-dichlorophenoxyacetic acid induces oxidative stress and apoptosis in mouse testis. Pestic Biochem Physiol. 2017; 141:18-22. PMid: 28911736. https://doi.org/10.1016/j.pestbp.2016.10.006.
- Harada Y, Tanaka N, Ichikawa M, Kamijo Y, Sugiyama E, Gonzalez FJ, et al. PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice. Arch Toxicol. 2016; 90(12):3061-71. PMid: 26838045 PMCid: PMC6334304. https://doi.org/10.1007/s00204-016-1669-z.
- Amaral FG, Cipolla-Neto J. A brief review about melatonin, a pineal hormone. Arch Endocrinol Metab. 2018; 62(4):472-9. PMid: 30304113. https://doi.org/10.20945/2359-3997000000066.
- Mortezaee K, Najafi M, Farhood B, Ahmadi A, Potes Y, Shabeeb D, et al. Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review. Life Sci. 2019; 228:228-41. PMid: 31077716. https://doi.org/10.1016/j.lfs.2019.05.009.
- Yu K, Deng SL, Sun TC, Li YY, Liu YX. Melatonin regulates the synthesis of steroid hormones on male : a review. Molecules. 2018; 23(2):447. PMid: 29462985 PMCid: PMC6017169. https://doi.org/10.3390/molecules23020447.
- Indian National Science Academy (INSA). Guidelines for care and use of animals in scientific research. New Delhi, India; 2000.
- Amer SM, Aly FA. Genotoxic effect of 2,4-dichlorophe noxy acetic acid and its metabolite 2, 4-dichlorophenol in mouse. Mutat Res. 2001; 494(1-2):1-12. PMid: 11423340. https://doi.org/10.1016/S1383-5718(01)00146-2.
- Upadhyaya AM, Rao MV, Jhala DD. Ameliorative effects of melatonin against 2,4-dichlorophenoxyacetic acid toxicity in kidney of mice-A histological study. Asian J Pharm Clin Res. 2018; 11(1):78-82. https://doi.org/10.22159/ajpcr.2018.v11i1.21829.
- Upadhyaya AM, Rao MV, Jhala DD. Melatonin attenuates 2,4-dichlorophenoxyacetic acid toxicity in kidney of mice. Toxicol Int. 2019; 25(2):130-8. http://www.informaticsjournals.in/index.php/toxi/article/view/23566.
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193:265-75.
- Zollner N, Kirsch K. Microdetermination of lipids by the sulfo-phospho-vanillin reaction. Z Ges Exp Med. 1962; 135:545-61.
- Zlatkis A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953; 41(3):486-92. PMid: 13035283. https://www.trans lationalres.com/article/0022-2143(53)90125-5/fulltext.
- Talalay P. [69] Hydroxysteroid dehydrogenases: Hydroxysteroid+ DPN+(TPN+)⇄ Ketosteroid DPNH (TPNH)+ H+. Methods Enzymol. 1962; 5:512-26. Academic Press. https://doi.org/10.1016/S0076-6879(62)05269-6.
- WHO laboratory manual for the examination and pro cessing of human semen, fifth edition. Geneva: World Health Organization. 2010. https://apps.who.int/iris/handle/10665/44261.
- Talbot P, Chacon RS. A triple‐stain technique for evaluating normal acrosome reactions of human sperm. J Exp Zool. 1981; 215(2):201-8. PMid: 6168732. https://doi.org/10.1002/jez.1402150210.
- Cardiff RD, Miller CH, Munn RJ. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harbor Protoc. 2014; 2014(6):655-8. PMid: 24890205. https://doi.org/10.1101/pdb.prot073411.
- Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010; 31(2): 455-61. PMid: 19499576 PMCid: PMC3041641. https://doi.org/10.1002/jcc.21334.
- Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. PubChem in 2021: New data content and improved web interfaces. Nucleic Acids Res. 2021; 49(D1):D1388-95. PMid: 33151290 PMCid: PMC7778930. https://doi.org/10.1093/nar/gkaa971.
- Pereira de Jesus‐Tran K, Cote PL, Cantin L, Blanchet J, Labrie F, Breton R. Comparison of crystal structures of human androgen receptor ligand‐binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci. 2006; 15(5):987-99. PMid: 16641486 PMCid: PMC2242507. https://doi.org/10.1110/ps.051905906.
- Benach J, Filling C, Oppermann UC, Roversi P, Bricogne G, Berndt KD, et al. Structure of bacterial 3β/17β-hydroxysteroid dehydrogenase at 1.2 Å resolution: a model for multiple steroid recognition. Biochemistry. 2002; 41(50):14659-68. PMid: 12475215. https://doi.org/10.1021/bi0203684.
- Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, et al. Structural and biochemical insights into 7β‐hydroxysteroid dehydrogenase stereoselectivity. Proteins. 2016; 84(6):859-65. PMid: 27006087. https://doi.org/10.1002/prot.25036.
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, et al. The protein data bank. Nucleic Acids Res. 2000; 28(1):235-42. PMid: 10592235 PMCid: PMC102472. https://doi.org/10.1093/nar/28.1.235.
- BIOVIA, Dassault Systèmes, (BIOVIA Discovery Studio), v.16.1.0.15350, San Diego: Dassault Systemes; 2016.
- Shafeeq S, Mahboob T. Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model. Hum Exp Toxicol. 2020; 39(1):47-58. PMid: 31496303. https://doi.org/10.1177/0960327119874428.
- Troudi A, Sefi M, Amara IB, Soudani N, Hakim A, Zeghal KM, et al. Oxidative damage in bone and erythrocytes of suckling rats exposed to 2,4-dichlorophenoxyacetic acid. Pestic Biochem Physiol. 2012; 104(1):19-27. https://doi.org/10.1016/j.pestbp.2012.06.005.
- Tayeb W, Nakbi A, Trabelsi M, Attia N, Miled A, Hammami M. Hepatotoxicity induced by sub-acute exposure of rats to 2,4-Dichlorophenoxyacetic acid based herbicide “Desormone lourd”. J Hazard Mater. 2010; 180(1-3):225-33. PMid: 20447766. https://doi.org/10.1016/j.jhazmat.2010.04.018.
- Vawda AI, Mandlwana JG. The effects of dietary protein deficiency on rat testicular function. Andrologia. 1990; 22(6):575-83. PMid: 1712155. https://doi.org/10.1111/j.1439-0272.1990.tb02058.x.
- Paulino CA, Palermo-Neto J. Effects of acute 2,4-dichlorophenoxyacetic acid intoxication on some rat serum components and enzyme activities. Braz J Med Biol Res. 1991; 24(2):195-8. PMid: 1726651.
- Miller WL, Bose HS. Early steps in steroidogenesis: intracellular cholesterol trafficking. J Lipid Res. 2011; 52(12):2111-35. PMid: 21976778 PMCid: PMC3283258. https://doi.org/10.1194/jlr.r016675.
- Rone MB, Fan J, Papadopoulos V. Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta. 2009; 1791(7):646-58. PMid: 19286473 PMCid: PMC2757135. https://doi.org/10.1016/j.bbalip.2009.03.001.
- Uren Webster TM, Perry MH, Santos EM. The herbicide linuron inhibits cholesterol biosynthesis and induces cellular stress responses in brown trout. Environ Sci Technol. 2015; 49(5):3110-8. PMid: 25633873. https://doi.org/10.1021/es505498u.
- Kelley RI, Hennekam RC. The Smith-Lemli-Opitz syndrome. J Med Genet. 2000; 37(5):321-35. PMid: 10807690 PMCid: PMC1734573. https://doi.org/10.1136/jmg.37.5.321.
- Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004; 25(6):947-70. PMid: 15583024. https://doi.org/10.1210/er.2003-0030.
- Fluck CE, Pandey AV. Steroidogenesis of the testis -- new genes and pathways. Ann Endocrinol (Paris). 2014; 75(2):40-7. PMid: 24793988. https://doi.org/10.1016/j.ando.2014.03.002.
- Dantas TA, Cancian G, Neodini DN, Mano DR, Capucho C, Predes FS, et al. Leydig cell number and sperm production decrease induced by chronic ametryn exposure: A negative impact on animal reproductive health. Environ Sci Pollut Res Int. 2015; 22(11):8526-35. PMid: 2556125. https://doi.org/10.1007/s11356-014-4010-5.
- Dutta HM, Meijer HJ. Sublethal effects of diazinon on the structure of the testis of bluegill, Lepomis macrochirus: a microscopic analysis. Environ Pollut. 2003; 125(3):355-60. PMid: 12826413. https://doi.org/10.1016/s0269-7491(03)00123-4.
- Rato L, Alves MG, Socorro S, Cavaco JE, Oliveira PF. Blood testis barrier: how does the seminiferous epithelium feed the developing germ cells. Endothelium and Epithelium: Composition, Functions and Pathology. 2011:137-55.
- Ray SD, Lam TS, Rotollo JA, Phadke S, Patel C, Dontabhaktuni A, et al. Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. Biofactors. 2004; 21(1-4):223-32. PMid: 15630201. https://doi.org/10.1002/biof.552210144.
- Aydin H, Ozdemir N, Uzunoren N. Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys. Forensic Sci Int. 2005; 153(1):53-7. PMid: 15935583.https://doi.org/10.1016/j.forsciint.2005.04.018.
- Kim CS, Keizer RF, Pritchard JB. 2,4-Dichlorophenoxyacetic acid intoxication increases its accumulation within the brain. Brain Res. 1988; 440(2):216-26. PMid: 3359212. https://doi.org/10.1016/0006-8993(88)90989-4.
- Tichati L, Trea F, Ouali K. Potential Role of Selenium Against Hepatotoxicity Induced by 2,4-Dichlorophenoxyacetic Acid in Albino Wistar Rats. Biol Trace Elem Res. 2020; 194(1):228-36. PMid: 31190189. https://doi.org/10.1007/s12011-019-01773-9.
- Salehi B, Sharopov F, Fokou PVT, Kobylinska A, Jonge L, Tadio K, Sharifi-Rad J, Posmyk MM, Martorell M, Martins N, Iriti M. Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans. Cells. 2019; 8(7):681. PMid: 31284489 PMCid: PMC6678868. https://doi.org/10.3390/cells8070681.
- Suzen S. Melatonin and synthetic analogs as antioxidants. Curr Drug Deliv. 2013; 10(1):71-5. PMid: 22998047. https://doi.org/10.2174/1567201811310010013.
- Kaur N, Sharma M, Lonare MK, Udehiya R, Singh D. Bio-antioxidants protect the buffalo bone marrow derived mesenchymal stem cells against oxidative stress induced during freeze-thaw cycle. Toxicol Int. 2021; 28(1):17-30. http://informaticsjournals.in/index.php/toxi/article/view/24809.
- Xu D, Liu L, Zhao Y, Yang L, Cheng J, Hua R, et al. Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner. J Pineal Res. 2020; 69(4):e12690. PMid: 32761924. https://doi.org/10.1111/jpi.12690.
- Choi Y, Attwood SJ, Hoopes MI, Drolle E, Karttunen M, Leonenko Z. Melatonin directly interacts with cholesterol and alleviates cholesterol effects in dipalmi toylphosphatidylcholine monolayers. Soft Matter. 2014; 10(1):206-13. PMid: 24651707. https://doi.org/10.1039/c3sm52064a.
- Li C, Zhou X. Melatonin and male reproduction. Clin Chim Acta. 2015; 446:175-80. PMid: 25916694.
- https://doi.org/10.1016/j.cca.2015.04.029.
- Srivastava RK, Krishna A. Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi. J Steroid Biochem Mol Biol. 2010; 118(1-2):107-16. PMid: 19897034. https://doi.org/10.1016/j.jsbmb.2009.11.001.
- Yang WC, Tang KQ, Fu CZ, Riaz H, Zhang Q, Zan LS. Melatonin regulates the development and function of bovine Sertoli cells via its receptors MT1 and MT2. Anim Reprod Sci. 2014; 147(1-2):10-6. PMid: 24768045. https://doi.org/10.1016/j.anireprosci.2014.03.017.
- Cipolla-Neto J, Amaral FG, Soares Jr JM, Gallo CC, Furtado A, Cavaco JE, et al. The crosstalk between melatonin and sex steroid hormones. Neuroendocrinology. 2021:1-15. PMid: 33774638. https://doi.org/10.1159/000516148.
- Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, et al. Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach. Drug Des Devel Ther. 2019; 13:2715-27. PMid: 31447548 PMCid: PMC6683968. https://doi.org/10.2147/dddt.s207310.
- Protective Effects Of Melatonin Against 2,4-dichlorophenoxyacetic Acid Induced Altered Haematological Variables In Mice: An In Vivo And In Silico Approach
Abstract Views :112 |
PDF Views:0
Authors
Affiliations
1 Reproductive Physiology Laboratory, Department Of Zoology, Biomedical Technology And Human Genetics, University School Of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
2 GSBTM Sponsored Bioinformatics Nodal Centre, Institute Of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
3 GSBTM Sponsored Bioinformatics Nodal Centre, Institute of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
1 Reproductive Physiology Laboratory, Department Of Zoology, Biomedical Technology And Human Genetics, University School Of Sciences, Gujarat University, Ahmedabad – 380009, Gujarat, IN
2 GSBTM Sponsored Bioinformatics Nodal Centre, Institute Of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
3 GSBTM Sponsored Bioinformatics Nodal Centre, Institute of Science, Nirma University, Ahmedabad – 382481, Gujarat, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 2 (2022), Pagination: 275-288Abstract
2,4-Dichlorophenoxyacetic acid (2,4-D) is a systemic phenoxy herbicide that induces oxidative stress. In contrast, melatonin is a secretory product of the pineal gland with antioxidant properties. In the present study, the ameliorative potential of melatonin (10 mg/kg body weight) was investigated against 2,4-D (low, mid, and high dose-16.5, 33.0, and 66.0 mg/kg body weight) induced altered haematological variables using in vivo and in silico models. Doses of 2,4-D and melatonin were administered orally for 28 days. The evaluated haematological indices in the present study were Haemoglobin (Hb), Red Blood Corpuscles (RBC), Haematocrit (HCT), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), White Blood Corpuscles (WBC), Lymphocytes, Monocytes, Granulocytes, Platelet Count (PT), Mean Platelet Volume (MPV), Plateletcrit (PCT), and Erythrocyte Sedimentation Rate (ESR). The statistical significant value was considered at p<0.05. Molecular docking study was performed for interaction of 2,4-D and melatonin with haemoglobin. In vivo results revealed that 2,4-D treatment showed a significant dose-dependent alteration in above all studied haematological indices. No significant auto reversal effects were observed in the withdrawal study, on the contrarily, the altered haematological indices were normalized and comparable to control when melatonin was given alone and in combination with 2,4-D. In silico results also demonstrated that 2,4-D and melatonin showed competitive bindings with haemoglobin. In nutshell, these in vivo and in silico findings depicted those haematological indices were altered by 2,4-D toxicity and can be abridged by melatonin attributed to its ameliorative potential as also evidenced by molecular docking.Keywords
2,4-dichlorophenoxyacetic Acid, Haematotoxicity, Melatonin, Mice, Protection.References
- Sharma A, Kumar V, Shahzad B, Tanveer M, Sidhu GP, Handa N, et al. Worldwide pesticide usage and its impacts on ecosystem. SN Appl Sci. 2019; 1(11):1446. https://doi.org/10.1007/s42452-019-1485-1.
- Atwood D, Paisley-Jones C. Pesticides industry sales and usage: 2008-2012 market estimates. U.S. Environmental Protection Agency (EPA). Washington, DC; 2017. https://www.epa.gov/sites/production/files/2017-01/documents/pesticides-industry-sales-usage-2016_0.pdf.
- Zuanazzi NR, de Castilhos Ghisi N, Oliveira EC. Analysis of global trends and gaps for studies about 2,4-D herbicide toxicity: a scientometric review. Chemosphere. 2020;241:125016. PMid: 31683446. https://doi.org/10.1016/j.chemosphere.2019.125016.
- Magnoli K, Carranza CS, Aluffi ME, Magnoli CE, Barberis CL. Herbicides based on 2,4-D: its behavior in agricultural environments and microbial biodeg radation aspects. A review. Environ Sci Pollut Res Int. 2020; 27(31):38501-12. PMid: 32770339. https://doi.org/10.1007/s11356-020-10370-6.
- Health Canada. 2,4-D in Drinking Water - For Public Consultation. Guidelines for Canadian Drinking Water Quality: Guideline Technical Document; 2020. https://www.canada.ca/content/dam/hc-sc/documents/programs/consultation-review-guideline-technical-document-2-4-d-drinking-water/2-4-D-GTDConsultation-20200727-eng.pdf.
- Health Canada. Residue limits for pesticides data base: 2,4-D. Health Canada, Consumer Product Safety, Pesticides and Pest Management. 2018. https://pr-rp.hc-sc.gc.ca/mrl-lrm/index-eng.php.
- Islam F, Wang J, Farooq MA, Khan MS, Xu L, Zhu J, et al. Potential impact of the herbicide 2,4-dichlorophenoxyacetic acid on human and ecosystems. Environ Int. 2018; 111:332-51. PMid: 29203058. https://doi.org/10.1016/j.envint.2017.10.020.
- Bojarski B, Witeska M. Blood biomarkers of herbicide, insecticide, and fungicide toxicity to fish-a review. Environ Sci Pollut Res Int. 2020; 27(16):19236-50. PMid: 32248419. https://doi.org/10.1007/s11356-020-08248-8.
- Bukowska B, Reszka E, Duda W. Influence of phenoxyherbicides and their metabolites on the form of oxy- and deoxyhemoglobin of vertebrates. Biochem Mol Biol Int. 1998; 45(1):47-59. PMid: 9635129. https://doi.org/10.1080/15216549800202422.
- Ateeq B, Abul farah M, Niamat Ali M, Ahmad W. Induction of micronuclei and erythrocyte alterations in the catfish Clarias batrachus by 2,4-dichlorophenoxyacetic acid and butachlor. Mutat Res. 2002; 518(2):135-44. PMid: 12113764. https://doi.org/10.1016/S1383-5718(02)00075-X.
- Bukowska B. Effects of 2,4-D and its metabolite 2,4-dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes. Comp Biochem Physiol C Toxicol Pharmacol. 2003; 135(4):435-41. PMid: 12965188. https://doi.org/10.1016/S1532-0456(03)00151-0.
- Soloneski S, Gonzalez NV, Reigosa MA, Larramendy ML. Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)-induced cytogenetic damage in human lymphocytes in vitro in presence of erythrocytes. Cell Biol Int. 2007; 31(11):1316-22. PMid: 17606385. https://doi.org/10.1016/j.cellbi.2007.05.003.
- Soni R, Gaherwal S, Shiv G. Effect of herbicide 2,4-D on hematological parameters of Clarias batrachus. Int J Curr Res Life Sci. 2018; 7(7):2441-4. http://journalijcrls.com/sites/default/files/issues-pdf/01448.pdf.
- Kubrak OI, Atamaniuk TM, Storey KB, Lushchak VI. Goldfish can recover after short-term exposure to 2,4-dichlorophenoxyacetate: use of blood parameters as vital biomarkers. Comp Biochem Physiol C Toxicol Pharmacol. 2013; 157(3):259-65. PMid: 23291397. https://doi.org/10.1016/j.cbpc.2012.12.005.
- Carrillo-Vico A, Lardone PJ, Alvarez-Sanchez N, Rodriguez-Rodriguez A, Guerrero JM. Melatonin: buffering the immune system. Int J Mol Sci. 2013; 14(4):8638-83. PMid: 23609496 PMCid: PMC3645767. https://doi.org/10.3390/ijms14048638.
- Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre‐Jimenez M, Qin L. Melatonin as an antioxidant: under promises but over delivers. J Pineal Res. 2016; 61(3):253-78. PMid: 27500468. https://doi.org/10.1111/jpi.12360.
- Acuna-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, Lopez LC, et al. Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci. 2014; 71(16):2997-3025. PMid: 24554058. https://doi.org/10.1007/s00018-014-1579-2.
- Li T, Yang Z, Jiang S, Di W, Ma Z, Hu W, et al. Melatonin: does it have utility in the treatment of haematological neoplasms? Br J Pharmacol. 2018; 175(16):3251-62.PMid: 28880375 PMCid: PMC6057911. https://doi.org/10.1111/bph.13966.
- Esteban M, Cuesta A, Chaves-Pozo E, Meseguer J. Influence of melatonin on the immune system of fish: a review. Int J Mol Sci. 2013; 14(4):7979-99. PMid: 23579958 PMCid: PMC3645727. https://doi.org/10.3390/ijms14047979.
- Upadhyaya AM, Rao MV, Jhala DD. Ameliorative effects of melatonin against 2,4-dichlorophenoxyacetic acid toxicity in kidney of mice- A histological study. Asian J Pharm Clin Res. 2018; 11(1):78-82. https://doi.org/10.22159/ajpcr.2018.v11i1.21829.
- Upadhyaya AM, Rao MV, Jhala DD. Melatonin attenuates 2,4-dichlorophenoxyacetic acid toxicity in kidney of mice. Toxicol Int. 2019; 25(2):130-8. http://www.informaticsjournals.in/index.php/toxi/article/view/23566.
- Indian National Science Academy (INSA). Guidelines for care and use of animals in scientific research. New Delhi, India; 2000.
- Amer SM, Aly FA. Genotoxic effect of 2,4-dichlorophenoxy acetic acid and its metabolite 2, 4-dichlorophenol in mouse. Mutat Res. 2001; 494(1-2):1-12. PMid: 11423340. https://doi.org/10.1016/S1383-5718(01)00146-2.
- Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010; 31(2): 455-61. PMid: 19499576 PMCid: PMC3041641. https://doi.org/10.1002/jcc.21334.
- Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 2021; 49(D1):D1388-95.PMid: 33151290 PMCid: PMC7778930. https://doi.org/10.1093/nar/gkaa971.
- Fermi G, Perutz MF, Shaanan B, Fourme R. The crystal structure of human deoxyhaemoglobin at 1.74 Å resolution. J Mol Biol. 1984; 175(2):159-74. PMid: 6726807. https://doi.org/10.1016/0022-2836(84)90472-8. 27.
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, et al. The protein data bank. Nucleic Acids Res. 2000; 28(1):235-42. PMid: 10592235 PMCid: PMC102472. https://doi.org/10.1093/nar/28.1.235.
- BIOVIA, Dassault Systemes, (BIOVIA Discovery Studio), v.16.1.0.15350, San Diego: Dassault Systemes, 2016.
- Akinrotimi OA, Abu OM, Bekibele DO, Udeme-Naa B, Aranyo AA. Haematological characteristics of Tilapia guineensis from Buguma Creek, Niger Delta, Nigeria. Elec J Env Agricult Food Chem. 2010; 9(8): 1415-22.
- Michael PO. Toxicity effect of atrazine on histology, haematology and biochemical indices of Clarias gariepinus. Int J Fish Aquat Stud. 2018; 6(3):87-92. https://www.fisheriesjournal.com/archives/2018/vol6issue3/PartB/6- 2-23-695.pdf.
- Safahieh A, Jaddi Y, Yavari V, Zadeh RS. Sub-lethal effects of herbicide paraquat on hematological parameters of benny fish Mesopotamichthys sharpeyi. Int Proc Chem Biol Environ Eng. 2012; 42:141-5. http://www.ipcbee.com/vol42/027-ICBEM2012-C30003.pdf.
- Galal AAA, Reda RM, Abdel-Rahman Mohamed A. Influences of Chlorella vulgaris dietary supplementation on growth performance, hematology, immune response and disease resistance in Oreochromis niloticus exposed to sub-lethal concentrations of penoxsulam herbicide. Fish Shellfish Immunol. 2018; 77:445-56. PMid: 29626668. https://doi.org/10.1016/j.fsi.2018.04.011.
- Abubakar YA, Iheanacho S, Ogueji E. Sublethal exposure and toxicity effect of propanil on hematology and serum biochemistry in Oreochromis niloticus in a static bioassay. Gazi Univ J Sci. 2018; 31(4):1048-62. https://dergipark.org.tr/en/download/article-file/584941.
- Vani T, Saharan N, Mukherjee SC, Ranjan R, Kumar R, Brahmchari RK. Deltamethrin induced alterations of hematological and biochemical parameters in fingerlings of Catla catla (Ham.) and their amelioration by dietary supplement of vitamin C. Pestic Biochem Physiol. 2011; 101(1):16-20. https://doi.org/10.1016/j.pestbp.2011.05.007.
- Akinrotimi OA, Abu OM, Agokel EO, Uedeme-Naa B. Effects of direct transfer to fresh water on the haematological parameters of Tilapia guineensis Bleeker, 1862.Anim Res Int. 2010; 7(2):1199-1205. https://www.ajol.info/index.php/ari/article/view/79771.
- Solomon KR, Carr JA, Du Preez LH, Giesy JP, Kendall RJ, Smith EE, et al. Effects of atrazine on fish, amphibians, and aquatic reptiles: a critical review. Crit Rev Toxicol. 2008; 38(9):721-72. PMid: 18941967. https://doi.org/10.1080/10408440802116496.
- Finsterbusch M, Schrottmaier WC, Kral-Pointner JB, Salzmann M, Assinger A. Measuring and interpreting platelet-leukocyte aggregates. Platelets. 2018; 29(7):677-85. PMid: 29461910 PMCid: PMC6178087. https://doi.org/10.1080/09537104.2018.1430358.
- Samanta P, Pal S, Mukherjee AK, Senapati T, Jung J, Ghosh AR. Assessment of adverse impacts of glyphosate based herbicide, excel mera 71 by integrating multi-level biomarker responses in fishes. Int J Environ Sci Technol. 2019; 16(10):6291-6300. https://doi.org/10.1007/s13762-018-2013-3.
- Tishkowski K, Gupta V. Erythrocyte Sedimentation Rate [Internet]. 2021. [Updated 2021 May 9]. In: StatPearls. Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557485/.
- Verma AK, Prakash S. Haematotoxicity of phorate, an organophosphorous pesticide on a freshwater fish, Channa punctatus (Bloch). Int J Agri Sci. 2018; 9(2):117-20. https://philpapers.org/rec/VERHOP.
- Sreekala LK. Impact of pesticide endosulfan on haematological parameters of Etroplus suratensis. Int J Inv Sci Res Tech. 2018; 3(6):540-4. https://ijisrt.com/impact-of-pesticide-endosulfan-on-haematological-parameters-of-etroplus-suratensis.
- Aydin H, Ozdemir N, Uzunoren N. Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys. Forensic Sci Int. 2005; 153(1):53-7. PMid: 15935583. https://doi.org/10.1016/j.forsciint.2005.04.018.
- Kim CS, Keizer RF, Pritchard JB. 2,4-dichlorophenoxyacetic acid intoxication increases its accumulation within the brain. Brain Res. 1988; 440(2):216-26. PMid: 3359212. https://doi.org/10.1016/0006-8993(88)90989-4.
- Kaur N, Sharma M, Lonare MK, Udehiya R, Singh D. Bio-antioxidants protect the buffalo bone marrow derived mesenchymal stem cells against oxidative stress induced during freeze-thaw cycle. Toxicol Int. 2021; 28(1):17-30. http://informaticsjournals.in/index.php/ toxi/article/view/24809.
- Sonmez MF, Narin F, Akkuş D, Turkmen AB. Melatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidney. Ren Fail. 2012; 34(4):480-6. PMid: 22260528. https://doi.org/10.3109/0886022X.2011.649678.
- Watson RR, editor. Melatonin in the promotion of health. 2nd ed. Boca Raton, Florida, USA: CRC Press; 2011.
- Reiter RJ, Tan DX, Kim SJ, Cruz MH. Delivery of pineal melatonin to the brain and SCN: Role of canaliculi, cerebrospinal fluid, tanycytes and Virchow-Robin peri-vascular spaces. Brain Struct Funct. 2014; 219(6):1873-87. PMid: 24553808. https://doi.org/10.1007/s00429-014-0719-7.
- Tanaka T, Yasui Y, Tanaka M, Tanaka T, Oyama T, Rahman KW. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem Biol Interact. 2009; 177(2):128-36. PMid: 19028472. https://doi.org/10.1016/j.cbi.2008.10.047.
- Sanchez-Barcelo EJ, Mediavilla MD, Tan DX, Reiter RJ. Clinical uses of melatonin: Evaluation of human trials. Curr Med Chem. 2010; 17(19):2070-95. PMid: 20423309. https://doi.org/10.2174/092986710791233689.
- Banerjee A, Chattopadhyay A, Pal PK, Bandyopadhyay D. Melatonin is a potential therapeutic molecule for oxidative stress induced red blood cell (RBC) injury: A review. Melatonin Res. 2020; 3(1):1-31. https://doi.org/10.32794/mr11250045.
- Pablos MI, Agapito MT, Gutierrez R, Recio JM, Reiter RJ, Barlow‐Walden L, et al. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res. 1995; 19(3):111-5. PMid: 8750343. https://doi.org/10.1111/j.1600-079X.1995.tb00178.x.
- Rosengarten H, Meller E, Friedhoff AJ. In vitro enzymatic formation of melatonin by human erythrocytes. Res Commun Chem Pathol Pharmacol. 1972; 4(2):457-65. PMid: 5074537.
- Tesoriere L, D’Arpa D, Conti S, Giaccone V, Pintaudi AM, Livrea MA. Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity. J Pineal Res. 1999; 27(2):95-105. PMid: 10496145. https://doi.org/10.1111/j.1600-079X.1999.tb00602.x.
- Paul S, Naaz S, Ghosh AK, Mishra S, Chattopadhyay A, Bandyopadhyay D. Melatonin chelates iron and binds directly with phenylhydrazine to provide protection against phenylhydrazine induced oxidative damage in red blood cells along with its antioxidant mechanisms: an in vitro study. Melatonin Res. 2018; 1(1):1-20. https://doi.org/10.32794/mr11250001.
- Miller SC, Pandi PS, Esquifino AI, Cardinali DP, Maestroni GJ. The role of melatonin in immuno‐enhancement: potential application in cancer. Int J Exp Pathol. 2006; 87(2):81-7. PMid: 16623752 PMCid: PMC2517357. https://doi.org/10.1111/j.0959-9673.2006.00474.x.
- Ye JY, Liang EY, Cheng YS, Chan GC, Ding Y, Meng F, et al. Serotonin enhances megakaryopoiesis and proplatelet formation via p‐Erk1/2 and F‐actin reorganization. Stem Cells. 2014; 32(11):2973-82. PMid: 24980849. https://doi.org/10.1002/stem.1777.
- Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, et al. Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach. Drug Des Devel Ther. 2019; 13:2715-27. PMid: 31447548 PMCid: PMC6683968. https://doi.org/10.2147/DDDT.S207310.