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Madhuri, D.
- Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats
Authors
1 Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, IN
2 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana, IN
3 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 27, No 1&2 (2020), Pagination: 54-57Abstract
The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.Keywords
Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats.References
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- Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats
Authors
1 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
2 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Korutla, Jagtial District – 505326, Telangana, IN
3 Controller of Examinations, PVNRTVU, Administrative Office, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
4 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal District – 506166 , Telangana, IN
5 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 4 (2022), Pagination: 475-480Abstract
The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes in group 3; in group 4 mild to moderate peri portal fibrosis. Kidney section in group 2 showed shrunken glomeruli, necrosis; kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing, mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.
Keywords
Cadmium, Chlorpyrifos, Lipid Peroxidation, Wistar Rats.References
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