Toxicology International (Formerly Indian Journal of Toxicology)

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Alteration of Serum Biochemical Parameters Due to Cow Urine Distillate in Triazophos Intoxicated White Leghorn Cockerels


Affiliations
1 Department of Pathology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India
2 Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India
     

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In this study twenty five white leghorn male chicken of one month and one week old weighing about 244 to 248 gms were procured and were kept at Instructional Poultry Farm Nagla, Pantnagar. The birds in poultry shed were reared in deep litter system, were kept under standard managemental conditions and were randomly divided into five groups of 5 birds each. After one week of adaptation period, different doses of Triazophos were administered via feed at 2.5, 5 ppm level and cow urine distillate was administered via feed. At 2.5, 5 ppm level and cow urine distillate was administered through drinking water at the rate of 1ml per bird per day to groups G4, G5 respectively for 100 days daily. White leghorn cockerels are layers not broilers and can sustain for a period of 2-3 years. The birds of group “G1” served as control. After every 25 days blood was taken from each bird including day zero for study of different. viz. glucose, total protein, albumin, globulin, cholesterol, creatinine, uric acid, alanine aminotransferase ALT and aspartate aminotransferase AST.

Total protein, Albumin, globulin, parameters showed significant (P<0.01) decrease while in Cholesterol, Creatinine, Glucose, Uric Acid, ALT, AST showed a significant increase (P<0.01) in different doses of Triazophos treated birds in comparison to birds of control group while a significant increase (P<0.01) in Total protein, Albumin, globulin and a significant decrease (P<0.01) Cholesterol, Creatinine, Glucose, Uric Acid, ALT, AST was observed in cow urine treated groups (G4, G5) as compared to non cow urine treated groups (G2 and G3).


Keywords

Alanine Aminotransferase ALT, Aspartate Aminotransferase AST Test, Albumin, Cholesterol, Creatinine, Globulin, Glucose, Total Protein, Triazophos Toxicity, White Leghorn Cockerels, Uric Acid.
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  • Gardening and Landscaping. 21.5.13. (www.gardeningnlandscaping.com).

  • Jeyaratnam J. Acute Pesticide poisoining: A major global health problem. World Health Statistics Quarterly. 1990; 43(3): 139–44. PMid:2238694

  • Gupta RC. Veterinary Toxicology Basic And Clinical Principles. Academic Press. U.S.A. 1st edition. 2007; p. 502– 4. https://doi.org/10.5005/jp/books/10078

  • Naveed A, Venkateshwaralu P and Janaiah C. Biochemical alteration induced by triazophos in the blood plasma of fish, Chanu punctatus (Blosch). Annals of Biological Research. 2011; 2(4): 31–7.

  • Linda B, Nakure HS, Matsumoto M, Gainer JH and Kerkuliet NI. The broiler chicken as a model for immunotoxicity assessment: Standarization of in vitro immunological assay. Fundamentals of applied Toxicology. 1989; 12: 773–86. https://doi.org/10.1016/0272-0590(89)90009-2

  • Chauhan RS and Singhal L. Harmful effects of pesticides and their control through cowpathy. International Journal of Cow Science. 2006; 2(1): 61–70.

  • Kaplan LA, Carbohydrate and metabolite. In clinical chemistry: Theory, analysis and correlation, Kaplan L.A. and Pesce AJ, Eds Mosby CV, Toronto. 1984; p. 1032–40. PMid:6593685

  • Koller A. Proteins, Clinical chemistry: Theory analysis and correlation, Kaplan L.A. and Pesce A.J., Eds Mosby C.V., Toronto. 1984; p. 1268–327.

  • Gendler S. Protiens, Clinical Chemistry: Theory, Analysis and Correlation, Kaplan L.A. and Pesce A.J., Eds Mosby C.V., Toronto. 1984; p. 1268–327.

  • Murry RL. Non protein nitrogen compounds. Clinical chemistry: theory analysis and correlation, Kaplan L.A. and Pesce A.J., Eds Mosby C.V., Toronto. 1984; p. 1230–68. PMCid:PMC239700

  • Moss DW and Henderson AK. Clinical Enzymology, Tietz Textbook of Clinical Chemistry, 3rd ed., C.A. Burtis and E.R. Ashwood, Eds. W.B. Saunders, Philadelphia. 1994; p. 617–721. PMid:10057494

  • Koari-Siapere O. Some alteration in haematological parameters in Clarias isheriensis (Sydenham) exposed to sublethal concentration of water borne lead. Bioscience Research Communications. 1995; 8(2): 93–8.

  • Singh G, Sharma LD, Singh SP and Ahmed AH. Haematobiochemical profiles in cockerels following prolonged feeding of fenvelerate. Indian Journal of Toxicology. 2001; 8(2): 141–5.

  • Garg S. Immunopathological effects of gamma-BHC and quinalphos in chicken. Thesis, M.V.Sc. G.B. Pant University of Agriculture and Technology, Pantnagar. 2000; p. 32–40.

  • Singh AK. Clinicopathological studies of chronic endosulfan and chlorpyriphos intoxication in poultry. Thesis, M.V.Sc. G.B. Pant University of Agriculture and Technology, Pantnagar. 2003; p. 37.

  • Parmar RKS. Clinicopathological and immunopathological studies on alphamethrin toxicity in calves. Thesis, M.V.Sc. G.B. Pant University of Agriculture and Technology, Pantnagar. 1999; p. 32–9.

  • Garg N. Assessing the effect of cow urine as a possible feed additive on production performance and immunity of white leghorn layers. Thesis, M.Sc. G.B. Pant University of Agriculture and Technology, Pantnagar. 2004; p. 54–86.

  • Jayashree U, Reddy G, Reddy A, Anjaneyulu KSN and Kalakumar B. Evalvation of vitamin E against deltamethrin toxicity in broiler chicks. Indian Journal of Physiology and Pharmacology. 2003; 47(4): 447–52.

  • Purohit TJ. Subacute oral toxicity study of acephate in synthetic White Leghorn birds. Thesis, M.V.Sc. Anand Agricultural University, Anand. 2005; p. 27–9.

  • Varsheneya C, Bagha HS and Sharma LD. Effect of insecticides on humoral immune response in cockerels. British Veterinary Journal. 1988; 144: 610–2. https://doi.org/10.1016/0007-1935(88)90032-2

  • Parmar RKS. Clinicopathological and immunopathological studies on alphamethrin toxicity in calves. Thesis, M.V.Sc. G.B. Pant University of Agriculture and Technology, Pantnagar. 1999; p. 32–9.

  • Hanafy MSM, Arbid MS and Afify MMH. Biochemical and histopathological effects of the organophosphorous insecticide (Tamaron) in rats. Indian Journal of Animal Sciences.1991; 61(1): 43–7.

  • Garg UK, Pal AK, Jha GJ and Jadhao SB. Haematobiochemical and immune-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks. International Immunopathology. 2004; 4: 1709–22.

  • Ahmed MB and Khater MR. The evaluation of the protective potential of Ambrosia maritima extract on acetaminopheninduced liver damage. Journal of Ethnopharmacology. 2001; 75: 69–174. https://doi.org/10.1016/S0378-8741(00)00400-1


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  • Alteration of Serum Biochemical Parameters Due to Cow Urine Distillate in Triazophos Intoxicated White Leghorn Cockerels

Abstract Views: 249  |  PDF Views: 0

Authors

Astha Chandra
Department of Pathology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India
Seema Agarwal
Department of Pathology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India
Deepti Singh
Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India
Amit Patil
Department of Pathology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar – 263145, Udham Singh Nagar, Uttarakhand, India

Abstract


In this study twenty five white leghorn male chicken of one month and one week old weighing about 244 to 248 gms were procured and were kept at Instructional Poultry Farm Nagla, Pantnagar. The birds in poultry shed were reared in deep litter system, were kept under standard managemental conditions and were randomly divided into five groups of 5 birds each. After one week of adaptation period, different doses of Triazophos were administered via feed at 2.5, 5 ppm level and cow urine distillate was administered via feed. At 2.5, 5 ppm level and cow urine distillate was administered through drinking water at the rate of 1ml per bird per day to groups G4, G5 respectively for 100 days daily. White leghorn cockerels are layers not broilers and can sustain for a period of 2-3 years. The birds of group “G1” served as control. After every 25 days blood was taken from each bird including day zero for study of different. viz. glucose, total protein, albumin, globulin, cholesterol, creatinine, uric acid, alanine aminotransferase ALT and aspartate aminotransferase AST.

Total protein, Albumin, globulin, parameters showed significant (P<0.01) decrease while in Cholesterol, Creatinine, Glucose, Uric Acid, ALT, AST showed a significant increase (P<0.01) in different doses of Triazophos treated birds in comparison to birds of control group while a significant increase (P<0.01) in Total protein, Albumin, globulin and a significant decrease (P<0.01) Cholesterol, Creatinine, Glucose, Uric Acid, ALT, AST was observed in cow urine treated groups (G4, G5) as compared to non cow urine treated groups (G2 and G3).


Keywords


Alanine Aminotransferase ALT, Aspartate Aminotransferase AST Test, Albumin, Cholesterol, Creatinine, Globulin, Glucose, Total Protein, Triazophos Toxicity, White Leghorn Cockerels, Uric Acid.

References





DOI: https://doi.org/10.18311/ti%2F2018%2F21413