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Correlation of Low Birth Weight of Neonates to Placental Levels of Zinc, Copper, Iron, Lipid Peroxidation and Glutathione
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This study was conducted to seek association between placental redox (antioxidant/oxidant) parameters and essential metals status (zinc, copper, iron) with birth weight. Placental tissue of pregnant women was collected and levels of zinc, copper and iron were analyzed by Inductively Coupled Plasma-Mass spectrometry. The level of glutathione (GSH) along with the metals was found to markedly decrease in study group, while MDA concentration was significantly higher as compared to control group. Glutathione was found to be positively associated with the levels of zinc and birth weight inspite of negative correlation being established between birth weight and MDA. Placental iron level was indicated to be constructive association with birth weight and was unlikely related with level of MDA. Our findings from the study group supports that damaged antioxidant defence mechanism status is well linked with elevated level of MDA and decreased concentrations of essential metals rendering lower birth weight in neonates.
Keywords
Birth Weight, Metals, Placental Tissue.
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- Stoll JB, Chapman IA (2008) The high-risk infant. Nelson Textbook of Pediatrics 18th edn. Philadelphia, Saunders, 1:698-711.
- Anand M, Agarwal P, Singh L,Taneja A (2015) Persistent organochlorine pesticides and oxidant/ antioxidant status in the placental tissue of the women with full-term and preterm deliveries. Toxicol Res 4: 326-332.
- Myatt L, Cui X (2004) Oxidative stress in the placenta. Histochem Cell Biol122:369–382.
- Bushra M, Elhassan EM, Ali NI, Osman E, Bakheit KH, Adam II (2010) Anaemia, zinc and copper deficiencies among pregnant women in central Sudan. Biol Trace Elem Res137: 255-261
- Zeyrek D, Soran M, Cakmak AKocyigit A, Iscan A (2009) Serum Copper and Zinc Levels in Mothers and Cord Blood of their Newborn Infants with Neural Tube Defects: A Study-control Study. Indian Pediatr 46:675-680.
- Colemon JE (1992) Zinc proteins: Enzymes, storage proteins, transcreption factors, and replication proteins Ann Rev Biochem61: 897-946.
- Ohkawa H, Ohishi N, Yagi K (1979)Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem95:351-358.
- Ellman GL (1959) Tissue sulfhydryl groups. Arch BioachmBiophys82: 70-74.
- Singh J, Singh VK, Anand M, Kumar P, Siddiqui MKJ (2010) Placental Lead and its Interaction with Some Essential Metals among Women from Lucknow, India. Asian J Med Sci 1:32-36.
- Young-Ju K, Yun-Chul H, Kwan-Hee L,HeonJoo P, Eun Ae P, Hye- Sung M et al (2005) Oxidative stress in pregnant women and birth weight reduction. ReprodToxicol 19:487-492.
- Manzano EC, Postigo OE, Osorio JC, Moreno ML, Ojea MM, Valdes Izaguirre LE (2015) Maternal oxidant and antioxidant status in the third trimester of gestation and its relation to the birthweight. Obstert Gynecol: An Int J 2015: 1-10.
- Allen LH (2001) Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. J Nutr131: 581-589.
- Sundaram RC, Selvaraj N, Vijayan G,Bobby Z, Hamid A, RattinaDasse N (2007) Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment. Biomed Pharmacother 61:682–685.
- Fall CH, Yajnik CS, Rao S, Davies AA, Brown N, Farrant HJ (2003) Micronutrients and fetal growth. J Nutr5:1747-1756.
- Uriu-Adams JY, Scherr RE, Lanoue L, Keen CL. Influence of copper on early development: prenatal and postnatal considerations. Biofactors 2010; 36:136-152.
- Srivastava S, Mehrotra PK, Srivastava SP,Siddiqui MKJ (2002) Some essential elements in maternal and cord blood in relation to birth weight and gestational age of the baby. Biol Trace Elem Res2:97-105.
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