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Sub-Acute Exposure of Fenvalerate in Buffalo Calves:Toxicokinetic Evaluation
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The effect of sub-acute fenvalerate administration on its toxicokinetics was studied in male buffalo calves. Four healthy male buffalo calves were administered fenvalerate orally (@ 1 mg.kg-1.day-1) for 21 consecutive days. On day one, blood samples were collected for upto 48 h post administration for toxicokinetic study. The calves were then drenched at the same dose rate for 21 days and sampling was repeated on 21st day for toxicokinetic analysis. Concentrations of fenvalerate in the serum samples were analysed using gas chromatography (GC) and toxicokinetic parameters were calculated as per the non compartmental analysis. Significantly reduced distribution at steady state (0.11 L.kg-1 Vs 0.19 L.kg-1) on 21st day of continuous exposure compared to day one, clearly indicated limited distribution of the pesticide in various body fluids and tissues upon repeated administration. There was improved persistence of toxicant in the body upon sub-acute exposure as shown by significant increase in area under curve (AUC=156.4 Vs 69.1 μg.h.ml-1) after sub-acute administration. This fact was further supported by increased mean residence time (MRT=16.7 h Vs 12.6 h) of the pesticide. There was significant increase in the elimination half life (11.6 h Vs 8.74h) of the toxicant on day 21 compared to that observed on day 1, which was further underlined by a significant decrease in its clearance (0.006 Vs 0.015 L.kg-1.h-1). Sub-acute exposure of fenvalerate at the proposed dose rate resulted in limited tissue distribution, augmented persistence and slow elimination from the body of animals. This altered toxicokinetics of fenvalerate upon subacute exposure might be due to its effect on organs of metabolism and/elimination, thereby posing increased risk of toxicity in buffalo calves.
Keywords
Fenvalerate, Sub-Acute, Toxicokinetic, Gas Chromatography, Buffalo Calves.
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- Worthing C.R. and Walker S.B. (1987) The Pesticide ManualA World Compendium, eighth ed. Thornton Heath, British Crop Protection Council. 395-396.
- Gill K.K., Sandhu H.S. and Kaur R. (2014) Evaluation of Biochemical Parameters in Buffalo Calves Exposed to Sub-acute Fenvalerate Toxicosis. Proc Natl Acad Sci India Sect B Biol Sci. DOI 10.1007/s40011-014-0375-y.
- Akhtar M.H. (1983) Metabolism of fenvalerate by a chicken enzyme preparation. J. Agric. Food Chem. 31(5): 1080-1083.
- Gill K.K., Sandhu H.S. and Kaur R. (2014) Haematological alterations induced by oral subacute exposure to fenvalerate, nitrate and their combination in domesticbuffalo, bubalus bubalis, Bull Environ Contam Toxicol, 92: 703–707.
- Gong Z.C. (1990) Studies on toxicokinetics of 14C-fenvalerate in animals. Zhonghua Yu Fang Yi Xue Za Zhi, 24(5): 277-280. (http://www.ncbi.nlm.nih.gov/pubmed/ 2261813).
- Mandal T.K,. Bhattacharya A. Chakraborty A.K and Basa D.K. (1996) Disposition kinetics, cytotoxicity and residues of fenvalerate in tissues following oral administration to goats. Pest Manag Sci, 35(3):201–07.
- Ahmed M.T, Reda L.A, Loufty N.M, and Ali. T. (2008) The toxicity of fenvalerate, niclosamide and profenfos and some of their mixttures with a domestic detergent to Nile Tilapia fish with special reference to gill uptake and toxicokinetics of fenvalerate and fenvalerate-detergent mixture. Toxicol. Environ. Chem., 81(2): 81-96.
- Bradbury S.P, Coats J.R and McKim J.M (1986). Toxicokinetics of fenvalerate in rainbow trout (Salmo Gairdneri). Environ. Toxicol. Chem., 5(6): 567-576.
- Gill U.S, Schwartz H.M and Wheatley B. (1996) Development of a method for the analysis of PCB congeners and organochlorine pesticides in blood/serum. Chemosphere, 32: 1055-1061.
- Gibaldi M. and Perrier D. (1982) Pharmacokinetics, 2nd ed. Marcel and Dekker, New York.
- Ray D. E (1991) “Pesticides derived from plants and other organism,” in Handbook of Pesticide Toxicology, W. Y. Hayes, Jr. E. R., and Jr. Lows, Eds. San Diego CA: Academic Press, pp. 585–636.
- Godin S.J., Crow J.A., Scollon E.J., Hughes M.F., DeVito M.J., and Ross M.K. (2007) Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate. Drug Metab. Dispos. ,35:1664–1671.
- Cantalamessa F. (1993) Acute toxicity of two pyrethroids permethrin and cypermethrin in neonatal and adult rats. Archieves of Toxicology, 67: 510–513.
- Gilman A.U., Goodman L.S., and GIunan A. (1996) Goodman and Gilman’s The pharmacological basis of therapeutics, 6th ed. MacMillian, New York.
- Galinsky R.E., and Svensson C.K. (1995) Basic pharmacokinetics, in The Science and Practice of Pharmacy, 19th ed. Remington, J.P. Eds pp. Mack Publishing Company, Easton, PA, 724-740.
- Kuhn K.H., Weiseler B., Leng G., and Idel H. (1999) Toxicokinetics of pyrethroids in humans: consequences for biological monitoring. Bull. Environ. Contam. Toxicol., .62: 101-108.
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