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Toxic Evaluation of Subchronic Exposure to Cadmium, Imidacloprid, and their Combination on Hematological Parameters in Buffalo Calves
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The present investigation was undertaken to evaluate hematological alterations induced by oral subchronic exposure to cadmium, imidacloprid, and their combination in buffalo calves. Cadmium exposure produced a significant decrease in hemoglobin (Hb) concentration, Total Erythrocyte Count (TEC), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and MCH Concentration (MCHC). There was a significant increase in Total Leukocyte Count (TLC) but it did not produce any change in Erythrocyte Sedimentation Rate (ESR). Repeated oral administration of imidacloprid produced a significant decrease in Hb, PCV, TEC, MCV, MCH, and MCHC; however, there was a significant elevation in the levels of ESR and TLC. The combined exposure of cadmium and imidacloprid produced a significant decline in Hb concentration, PCV, TEC, MCV, and MCHC. It produced a significant increase in ESR and TLC, but no changes were observed in the levels of MCH.
Keywords
Buffalo Calves, Cadmium, Imidacloprid, Subchronic, Toxicity.
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- Goyer R. Toxic effect of metal. In: Klaassen CD, editor. Casarett and Doull’s Toxicology. The Basic Science of Poisons. 5th ed. New York: McGraw-Hill; 1995. p. 691–736.
- Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure– A review of the literature and a risk estimate. Scand J Work Environ Health 1998; 24 Suppl 1:1–51.
- Jarup L, Hellström L, Alfven T, Carlsson MD, Grubb A, Persson B, et al. Low level exposure to cadmium and early kidney damage: THe OSCAR study. Occup Environ Med 2000; 57:668–72.
- Llobet JM, Granero S, Torres A, Schuhmacher M, Domingo JL. Biological monitoring of environmental pollution and human exposure to metals in Tarragona, Spain III. Blood levels. Trace Elem Electrolytes. 1998; 15:76–80.
- Lafuente A, Márquez N, Pérez-Lorenzo M, Pazo D, Esquifino AI. Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol. 2000; 38:913–23.
- Quintas G, Armenta S, Garrigues S, Guardia MD. Fourier transform infrared determination of imidacloprid in pesticide formulations. J Braz Chem Soc. 2004; 15:307–12.
- Kidd H, James D. Agrochemicals Handbook. 3rd ed. Cambridge, England: Royal Society of Chemistry; 1994.
- Shimomura M, Okuda H, Matsuda K, Komai K, Akamatsu M, Sattelle DB. Effects of mutations of a glutamine residue in loop D of the alpha7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. Br J Pharmacol. 2002; 137:162–9.
- Benjamin MM. Outline of veterinary clinical pathology. 3rd ed. Ludhiana, India: Kalyani Publisher; 1985. p. 25, 48, 60.
- Kostic MM, Ognjanovic B, Dimitrijevic S, Zikic RV, Stajn A, Rosic GL, et al. Cadmium-induced changes of antioxidant and metabolic status in red blood cells of rats: In vivo effects. Eur J Haematol. 1993; 51:86–92.
- Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Umemura T, Marumo F. Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol Appl Pharmacol. 1996; 137:228–36.
- Chun YS, Choi E, Kim GT, Choi H, Kim CH, Lee MJ, et al. Cadmium blocks Hypoxia-Inducible Factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha. Eur J Biochem. 2000; 267:4198–204.
- Moore MR, Goldberg A, Yeung-Laiwah AA. Lead effects on the heme biosynthetic pathway. Relationship to toxicity. Ann N Y Acad Sci. 1987; 514:191–203.
- Turk JR, Casteel SW. Clinical biochemistry in toxicology. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical Biochemistry of Domestic Animals. 5th ed. San Diego: Academic Press; 1997. p. 829–44.
- Dacie JV, Lewis SM. Practical Haematology. 5th ed. Edinburgh: Churchill Livingstone; 1997. p. 580–2.
- Livingstone C, Kaur B, Sandhu HS, Kaur R. Toxic effects of subacute oral exposure of imidacloprid on biochemical parameters in crossbred cow calves. Toxicol Int. 2006; 13:43–7.
- Hassan GA, Salem MH, Aba-Allah GA, Shahar N, Tohraa AE. Effect of organophosphorus (dimethoat) and pyrithroid pesticide on plasma level of cortisol and thyronine and on some haematological characteristics in growing male rabbits. Indian J Anim Sci. 1988; 58:1395–401.
- Gossett KA. Anemias associated with drugs and chemicals. Schalm’s Veterinary Haematology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 185–9.
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