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Nayak, Usha Y.
- Design and Characterization of Valsartan Co-Crystals to Improve its Aqueous Solubility and Dissolution Behavior
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Authors
Affiliations
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal – 576104, IN
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal – 576104, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 26-30Abstract
The aim of the work was to prepare co-crystals of valsartan, a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid was found to be suitable co-former to prepare co-crystals with good physico-chemical properties. The solid state characterization of co-crystals were studied by FTIR, DSC and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. Solubility study in distilled water indicated low solubility of valsartan (198.5 μg/ml), there was 2.6 fold increase in the solubility of co-crystals prepared using succinic acid, with 1:5 drug to co-former ratio (520.6 μg/ml). Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus developed co-crystals were found to be suitable alternative to increase the solubility and dissolution rate of valsartan.Keywords
Valsartan, Co-Crystals, Solvent Evaporation, Co-Formers, Succinic Acid, Bioavailability.
- Solubility and Dissolution Improvement of Carbamazepine by Various Methods
Abstract Views :389 |
PDF Views:0
Authors
Shreya
1,
Ayesha Heena
1,
Ranjitha
1,
Amrutha A. Shetty
1,
Chetan H. Mehta
1,
Usha Y. Nayak
1,
Srinivas Mutalik
1,
K. Girish Pai
1
Affiliations
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, IN
1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3333-3337Abstract
This work was aimed to improve solubility and dissolution rate of carbamazepine (CBZ), an antiepileptic, BCS class II drug by using different solubility enhancement techniques. Self-nanoemulsifying drug delivery system (SNEDDS) and solid dispersions of CBZ was attempted by spontaneous emulsification method and fusion method, respectively. The solubility studies of pure CBZ was performed in different oils, surfactants and co-surfactants. Very small amount of CBZ (20 mg) could be incorporated in SNEDDS, however the solid dispersion of CBZ using Soluplus® was successfully prepared with the required dose. The solid dispersion was characterized and evaluated for saturation solubility, in vitro dissolution studies, solid state characterization such as fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction studies (XRD). Based on the results, it can be concluded that the due to increased solubility and the dissolution, the bioavailability of CBZ could be improved by preparing solid dispersion.Keywords
Carbamazepine, Self-Nanoemulsifying Drug Delivery System, Solid Dispersion, Spontaneous Emulsification Method, Fusion Method.References
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