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B, Sooriyapriya
- In Silico Inhibition Studies of Constituents of Abutilon Indicum on Xanthine Oxidase
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Authors
Affiliations
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai 3., IN
1 Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai 3., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 3 (2022), Pagination: 1133-1136Abstract
Objective: To find out the xanthine oxidase inhibitory potential of constituents reported from the Abutilon indicum through in silico studies as there is traditional claim supporting the use of this plant in treating gout. Method: The 33 constituents of Abutilon indicum were chosen for the study and their drug likeness were read using online application SwissADME. Molecular docking studies were done in Autodock version 1.5.6. The docked samples were viewed using Molegro Molecular Viewer 2.5.0. and Pymol. Allopurinol was used as standard to compare the docking scores of the plant constituents. Results: All the 33 compounds (A1-A33) exhibited drug likeness. Good binding energies were observed for 19 constituents against 3AX7 protein. 6 compounds such as luteolin, beta-amyrin,1-lycoperodine, chrysoeriol, quercetin and flavone possessed binding energies greater than 8 and good inhibition constant values. Conclusion: The constituents of Abutilon indicum has good xanthine oxidase inhibiting potential and can further be developed into a drug candidate against gout.Keywords
Abutilon indicum, Gout, Xanthine oxidase, Luteolin, Chrysoeriol.
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