Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jayanti, Shara
- Cytotoxic Effect of Allium cepa L. Extract on Human colon Cancer (WiDr) Cells:In Vitro Study
Abstract Views :281 |
PDF Views:0
Authors
Amaq Fadholly
1,
Arif N. M. Ansori
1,
Shara Jayanti
1,
Annise Proboningrat
1,
Muhammad K. J. Kusala
1,
Naimah Putri
1,
Fedik A. Rantam
1,
Sri A. Sudjarwo
1
Affiliations
1 Universitas Airlangga, Surabaya, 60115, ID
1 Universitas Airlangga, Surabaya, 60115, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3483-3486Abstract
The extract of Allium cepa L. is commonly used as adjuvant therapy for cancer that includes a potential source of anticancer properties. This study aimed to evaluate the cytotoxicity from a crude extract of Allium cepa L. against human colon cancer (WiDr) cells. The cytotoxic effect of Allium cepa L. extract was determined using MTT assay. The Allium cepa L. extract inhibited the proliferation of WiDr cells, but revealed no potent cytotoxicity with IC<50 value of 1363.29 μg/mL on WiDr cells. The results showed that Allium cepa L. extract was no longer active as an anticancer drug, but it would be more active using the direct-bioactive compound of Allium cepa L. Some intens observations are still required to maximize its potential as one of chemotherapeutic agents in the future. On the other hand, further studies are needed to obtain the right dose of Allium cepa L. extract that can inhibit the cell growth well and determine the accuracy of its mechanism on WiDr cells as one of therapeutic strategies to treat human colon cancer.Keywords
Allium cepa L, WiDr Cells, Cytotoxic.
References
- Chakraborty S, Hosen MI, Ahmed M, Shekhar HU. Onco-Multi-OMICS Approach: A New Frontier in Cancer Research. BioMed Research International. 2018; 9836256.
- Demir S, Turan I, Aliyazicioglu Y, Kilinc K, Yaman SO, Ayazoglu Demir E, Arslan A, Mentese A, Deger O. Morus rubra Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells through Endoplasmic Reticulum Stress and Telomerase. Nutrition and Cancer. 2017; 69(1): 74-83.
- Saleh S, Lam AK, Ho YH. Real-Time PCR Quantification of Human Telomerase Reverse Transcriptase (hTERT) in Colorectal Cancer. Pathology. 2008; 40(1): 25-30.
- Kim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK. Sex- and Gender-specific Disparities in Colorectal Cancer Risk. World Journal of Gastroenterology. 2015; 21(17): 5167-75.
- Rezaie-Tavirani M, Fayazfar S, Heydari-Keshel S, Rezaee MB, Zamanian-Azodi M, Rezaei-Tavirani M, Khodarahmi R. Effect of Essential Oil of Rosa damascena on Human Colon Cancer Cell Line SW742. Gastroenterology and Hepatology from Bed to Bench. 2013; 6(1): 25-31.
- Wahyuni DK, Ansori ANM, Vidiyanti F. GC-MS Analysis of Phytocomponent in Methanolic Extracts of Leaf-derived Callus of Justicia gendarussa Burm.f. Bioscience Research. 2017; 14(3): 668-677.
- dosSantos J, Oliveira DF, de Carvalho DA, Pinto JM, Campos VA, Mourão AR, Pessoa C, de Moraes MO, Costa-Lotufo LV. Evaluation of Native and Exotic Brazilian Plants for Anticancer Activity. Journal of Natural Medicines. 2010; 64(2): 231-8.
- Kuete V. Editor. Medicinal Spices and Vegetables from Africa. Academic Press. 2017; 329-349.
- Liguori L, Califano R, Albanese D, Raimo F, Crescitelli A, Matteo MD. Chemical Composition and Antioxidant Properties of Five White Onion (Allium cepa L.) Landraces. Journal of Food Quality. 2017; 2017: 6873651.
- Sak K. Chemotherapy and Dietary Phytochemical Agents. Chemotherapy Research and Practice. 2012; 2012: 282570.
- Greenwell M, Rahman PK. Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Sciences and Research. 2015; 6(10): 4103-4112.
- Seki T, Tsuji K, Hayato Y, Moritomo T, Ariga T. Garlic and Onion Oils Inhibit Proliferation and Induce Differentiation of HL-60 Cells. Cancer Letters. 2000; 160(1): 29-35.
- Chang HS, Yamato O, Yamasaki M, Ko M, Maede Y. Growth Inhibitory Effect of Alk(en)yl Thiosulfates Derived from Onion and Garlic in Human Immortalized and Tumor Cell lines. Cancer Letters. 2005; 223(1): 47-55.
- Votto AP, Domingues BS, de Souza MM, da Silva Júnior FM, Caldas SS, Filgueira DM, Clementin RM, Primel EG, Vallochi AL, Furlong EB, Trindade GS. Toxicity Mechanisms of Onion (Allium cepa) Extracts and Compounds in Multidrug Resistant Erythroleukemic Cell Line. Biological Research. 2010; 43(4): 429-37.
- Li W, Zhou J, Xu Y. Study of the In Vitro Cytotoxicity Testing of Medical Devices. Biomedical Reports. 2015; 3(5): 617-620.
- Baek HS, Yoo JY, Rah DK, Baek HS, Yoo JY, Rah DK, Han DW, Lee DH, Kwon OH, Park JC. Evaluation of The Extraction Method for The Cytotoxicity Testing of Latex Gloves. Yonsei Medical Journal. 2005; 46(4): 579-83.
- Mirhosseini H, Amid BT. Influence of Chemical Extraction Conditions on the Physicochemical and Functional Properties of Polysaccharide Gum from Durian (Durio zibethinus) Seed. Molecules. 2012; 17(6): 6465-80.
- Bonaccorsi P, Caristi C, Gargiulli C, Leuzzi U. Flavonol Glucosides in Allium Species: A Comparative Study by Means of HPLC–DAD– ESI-MS–MS. Food Chemistry. 2008; 107(4): 1668-1673
- Teyssier C, Amiot MJ, Mondy N, Auger J, Kahane R, Siess MH. Effect of Onion Consumption by Rats on Hepatic Drug-Metabolizing Enzymes. Food and Chemical Toxicology. 2001; 39(10): 981-7.
- Chang HS, Endoh D, Ishida Y, Takahashi H, Ozawa S, Hayashi M, Yabuki A, Yamato O. Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage caused by X-ray Irradiation in Cultured Cells: Antiradiation Potential of Onions and Garlic. The Scientific World Journal. 2012; 2012: 846750.
- Xiau H, and Parkin KL. Isolation and identification of potential cancer chemopreventive agents from methanolic extract of green onion (Allium cepa). Phytochemistry. 2007; 68(7): 1059-1067.
- Wang Y, Tian WX, Ma XF. Inhibitory Effects of Onion (Allium cepa L.) Extract on Proliferation of Cancer Cells and Adipocytes via Inhibiting Fatty Acid Synthase. Asian Pacific Journal of Cancer Prevention. 2012; 13(11): 5573-9.
- Park S, Kim MY, Lee DH, Lee SH, Baik EJ, Moon CH, Park SW, Ko EY, Oh SR, Jung YS. Methanolic Extract of Onion (Allium cepa) Attenuates Ischemia/Hypoxia-induced Apoptosis in Cardiomyocytes via Antioxidant Effect. European Journal of Nutrition. 2009; 48(4): 235-42.
- Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative Stress and Antioxidant Defense. World Allergy Organization Journal. 2012; 5(1): 9-19.
- Jeong CH, Joo SH. Downregulation of Reactive Oxygen Species in Apoptosis. Journal of Cancer Prevention. 2016; 21(1): 13-20.