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A. Oran, Sawsan
- Investigating the Anti-viral and Anti-bacterial Activities of Jordanian Medicinal Plants: A Narrative Review
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Authors
Affiliations
1 Department of Science, Atlantic Cape Community College, Mays Landing, NJ 08330,, US
2 Department of Biological Sciences, The University of Jordan, Amman,, JO
3 Centre for Cardiovascular Science, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh,, GB
1 Department of Science, Atlantic Cape Community College, Mays Landing, NJ 08330,, US
2 Department of Biological Sciences, The University of Jordan, Amman,, JO
3 Centre for Cardiovascular Science, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh,, GB
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 127-136Abstract
The diversity in Jordan’s flora due to its geographical areas make is well noted in the scientific literature. The challenge of disease and death caused by infectious diseases like viruses and bacteria, and as infectious diseases evolve and pathogens develop resistance to existing pharmaceuticals, the search for new novel leads, possibly with different modes of action, against bacterial and viral diseases has intensified in recent years. The intent of this review is to provide prevalent information on the antibacterial and antiviral potential in medicinal plants in Jordan, mode of action, type of viruses and bacteria, and phytochemical contents. It has been demonstrated by several studies presented in this review that medicinal plants in Jordan are rich in phytochemicals and possess antiviral and antibacterial properties.Keywords
Antibacterial, Antiviral, Medicinal plants, Phytochemicals, Microorganisms, Extracts.
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- Chemical Composition and Antiproliferative and Antioxidant Activities of Essential Oil from Juniperus Phoenicea L. Cupressaceae
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Authors
Affiliations
1 Department of Science, Atlantic Cape Community College, Mays Landing, NJ 08330,, US
2 Department of Biological Sciences, The University of Jordan, Amman,, JO
3 Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272,, AE
1 Department of Science, Atlantic Cape Community College, Mays Landing, NJ 08330,, US
2 Department of Biological Sciences, The University of Jordan, Amman,, JO
3 Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272,, AE
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 153-159Abstract
Being multipurpose, relatively safe, and widely favorable for consumption, interest in the essential oils of medicinal plants has been increasing. Essential oil (EO) of Juniperus phoenicea is traditionally used for treatment of several health problems such as diabetes, rheumatism, and cancer that is the second leading cause of death in Jordan. This study aims to collect and chemically analyze EO from Juniperus phoenicea L., from Jordan and to evaluate its cytotoxic and antioxidant activity against human breast cancer cells (T47D), colorectal adenocarcinoma cells (CACO2), and normal human fibroblasts (MRC5). EO was extracted by hydro-distillation and analyzed in a gas chromatograph coupled with a mass spectrometer. Cell viability was assessed using trypan blue, neutral red, and MTT assays, and antioxidant activity was evaluated using DPPH scavenging activity assay. Chemical composition analysis revealed 23 constituents in the EO, and the amount of α- pinene was the highest (69.71%). The results also revealed that the IC50 values of the viability assays were higher among normal cells compared to the human cancer cell lines, and the viability inhibition was significant at higher concentrations compared to untreated cells. Nevertheless, low antioxidant activity was observed for the oil in the DPPH scavenging activity test. To sum up, this study indicates that Jordanian Juniperus phoenicea EO, albeit unlikely to be an effective antioxidant, is optimistically potential to be utilized in breast and colon cancers treatment due to its preferential cytotoxicity against cancer cellsKeywords
Juniperus phoenicea, Essential oil, Cell viability, Antioxidant activity.References
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