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Ali, Sami
- Evaluation of the Effect of Simvastatin Therapy on Bone Remodeling in Rats
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Authors
Sami Ali
1,
Rana Makhous
2
Affiliations
1 Master Student, Department of Pharmacology and Toxicology, Tishreen University, Latakia,, SY
2 Professor, Department of Pharmacology and Toxicology, Tishreen University, Latakia,, SY
1 Master Student, Department of Pharmacology and Toxicology, Tishreen University, Latakia,, SY
2 Professor, Department of Pharmacology and Toxicology, Tishreen University, Latakia,, SY
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 525-528Abstract
Objective: The aim of this study was to evaluate the effect of simvastatin on the bone remolding markers in rats (experimental study). Materials and methods: The study involved 18 male Wistar rats, they were divided into three groups: Group I (n=6; control group), Group II (n=6; was administrated 7.5 mg/kg/ dexamethasone intra muscular for 2 months served as a model of osteoporosis [op]), Group III (n=6;was administered 7.5 mg/kg/ dexamethasone intra muscular for 2month and treated orally with 8mg/kg of simvastatin).After 8 weeks, serum acid phosphatase was determined for the three group. Results: The levels of serum acid phosphatase were notably elevated in the [op] group. Administration of simvastatin produced a significant decrease in the levels of serum acid phosphatase. Conclusion: simvastatin was able to decrease the rate of bone resorption in an animal model of osteoporosis induced by dexamethasone.Keywords
Statins, Simvastatin, Osteoporosis, ACP, Bone resorption.References
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