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Sathesh Kumar, S.
- A Prospective Study on Assessment of Quality of Life in Women Pre Operative and Post Operative Hysterectomy Patient in Gynaecology Department of A Tertiary Care Hospital
Abstract Views :186 |
PDF Views:10
Authors
Affiliations
1 School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University,Chennai-600117, Tamil Nadu, IN
1 School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University,Chennai-600117, Tamil Nadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 131-134Abstract
The study was about the assessment of quality of life in women pre operative and post operative hysterectomy patient. It's a prospective study carried out in 1 year (July 2015 to June 2016). The study was carried out in 300 bedded tertiary care hospitals. The department selected for the study was gynaecology. The patient underwent hysterectomy surgery were selected. A patient information form has been prepared to inform the patient about the purpose and necessity of the study. The quality of life was evaluated using questionnaire. There are two set of questionnaires. Pre operative questionnaire before surgery and post operative questionnaire after surgery were given to the patient's. There are score's given to each question. Per operative and post operative has been compared. The study population was about 50. Quality of life score before hysterectomy mean standard deviation value 14.34694±3.755546 and after hysterectomy mean standard deviation value 8.693878±3.70991 p value < 0.0001A significantly lower score was observed in patients after hysterectomy surgery. Quality of life scores showed a statistically significant p value<0.05 with 95% confidence interval. By comparing with before hysterectomy surgery after hysterectomy surgery quality of life was improved by decreasing the complication and score.Keywords
Hysterectomy, Pre-operative, Tertiary Care Hospital, Quality of Life, Prospective Study, Gynaecology, Questionnaire, Post Operative.- Pharmacokinetics of Tacrine Loaded MPEG-PCL Polymeric Nanoparticles
Abstract Views :142 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai- 600117, Tamilnadu, IN
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai- 600117, Tamilnadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 135-140Abstract
The Tacrine loaded mPEG-PCL nanoparticles were prepared by emulsion polymerization and solvent evaporation method, to improve the bioavailability of the drug in brain. The nanoparticulate formulation was characterized for particles size, encapsulation efficiency, zeta potential and in vitro release study. The pharmacokinetic studies of Tacrine-loaded mPEG-PCL nanoparticles were carried out in Sprague dawley rats. The study revealed Cmax and Tmax were significantly altered and Clearance was less in brain and blood when compared to that of plain Tacrine solution. These results suggest that mPEG-PCL nanoparticles had considerably increased the transport of Tacrine across the BBB.Keywords
Alzheimer’s Disease, Tacrine, Blood Brain Barrier (BBB), Emulsion Polymerization Method, Nanoparticles.- Preparation and Evaluation of Pramipexole Dihydrochloride Loaded Chitosan Nanoparticles for Brain-Targeting
Abstract Views :140 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Vels University, Chennai-600117, IN
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Vels University, Chennai-600117, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 245-251Abstract
The present investigation was undertaken to develop nanoparticles of a hydrophilic drug pramipexole dihydrochloride and improve the entrapment efficiency of the drug. Pramipexole dihydrochloride nanoparticles where prepared with two methods by using Chitosan and another method by utilizing Chitosan, sodium alginate and Pluronic F-127. Five different trials were prepared with different concentrations of Chitosan in both methods. In two methods variables were found to have significant effect on the particle size, entrapment efficiency of drug which is influenced by Chitosan and sodium alginate. The maximum entrapment efficiency and least particle size were obtained with 3% Chitosan along with sodium alginate PS3 of 220.7 nm with 32.4 mV zeta potential with 91.2 % entrapment efficiency but in PC3 with 3% Chitosan show least particle size of 252nm with 44.7 mV zeta potential but less entrapment efficiency 82.8 % of than PS3.The surface morphology of PC3 and PS3 shows smooth surface with the in vitro release of PC3 with 90.2 %, PS3 with 96.12% in 24 hrs. PS3 shows better entrapment efficiency than PC3, Hence preparation methods along with two polymers may influence in entrapment efficiency of pramipexole dihydrochloride nanoparticles which meet the treatment of Parkinson's disease which has a potential influence on brain-targeting.Keywords
Pramipexole Dihydrochloride, Chitosan Sodium Alginate, Entrapment Efficiency, Parkinson’s Disease.- Nanocarrier Based Anticancer Drug Delivery System:Current Trends and Prospects
Abstract Views :152 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, IN
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, IN