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S. Bulagouda, R.
- Sub Chronic Effect of High Fat Consumption on Heart Rate Variability and Nitric Oxide (No) in Experimental Rats: Protective Role of Terminalia Arjuna
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Authors
Affiliations
1 Assistant Professor, Department of Physiology, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
2 Assistant Professor, Department of Dentistry, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
3 Professor and Head, Department of Anatomy, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
4 Assistant Professor, Department of Anatomy, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
1 Assistant Professor, Department of Physiology, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
2 Assistant Professor, Department of Dentistry, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
3 Professor and Head, Department of Anatomy, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
4 Assistant Professor, Department of Anatomy, Shri B M Patil Medical College, Hospital and Research Centre BLDE (Deemed to be University), Bangaramma Sajjan Campus, Solapur Road, Vijayapura, 586103, Karnataka,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 535-540Abstract
Background: In the present study Albino wister rats displayed with increase in body weight, sympathetic activity and decreased parasympathetic function following a high fat consumption for a sub chronic period. Possible alterations of cardiac autonomic functions and molecular behaviour of nitric oxide were observed in the presence of ethanolic extract of Terminalia arjuna (ETA). Objectives: The study was aimed to find out impact of high fat diet on cardiac health in terms with HRV also through NO pathways alterations in experimental rats and to assess the cardio protective efficacy of Terminalia arjuna on hyperlipidemic rats. Methodology: Bark of Terminalia arjuna was extracted with 99% ethanol. Rats were grouped into four groups (n=6); Control as group 1 (20% fat); group 2 fed with (20% fat+ ETA 100 mg/kg/b w); group 3 fed with (30% fat) and group 4 fed with (30% fat + ETA 100mg/kg/b w). Body weight and percentage of body weight gain were calculated. Electrophysiological analysis(HRV and sympatho-vagal balance) were done. Biochemical assay was done to assess serum Nitric oxide levels(NO). ANOVA, Pearson’s correlation and multiple regression were done to analyze data. Results: Electrophysiological evaluation revealed altered sympatho-vagal balance in hyperlipidemic rats. Significant increase in sympathetic drive along with decrease in parasympathetic functions suggests cardiac autonomic dysfunction in rats fed with high fat. Subchronic supplementation of ethanolic extraction of Terminalia arjuna to hyperlipidemic rats showed significant beneficial effect on cardiac autonomic function. Significant negative correlation was observed between HRV and nitric oxide. Conclusion: Terminalia arjuna have exhibited its cardioprotective role in high fat fed rats by enhancing cardiac functions. Supplementation of ETA have shown important role in modulating autonomic control and in improving cardiovascular function. Probably polyphenolic compounds and flavonoids might have cardioprotective activity by rejuvenating action and free radical quenching actions.Keywords
Hyperlipidemic rats, Heart rate variability, Terminalia arjuna , Nitric oxide
References
- Das KK, Chadchan KS, Reddy RC, Biradar MS, Kanthe PS, Patil BS, Ambekar JG, Bagoji IB, Das S. Effects of some indigenous plants of North Karnataka (India) on cardiovascular and glucose regulatory systems in alloxan-induced diabetic rats. Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular and Hematological Agents). 2017 Apr 1;15(1):49-61.
- Priya Singh, Yogesh Shiv hare, UK Patil. Assessment of Hypolipidemic Potential of Chenopodium album Linn on Triton Induced Hyperlipidemic Rats. Research J. Pharm. and Tech. 3(1): Jan.-Mar. 2010; Page 187-192.
- Medai E, Lima Leopoldo AP, Pererira Junior PP, Leopold AS, Campos D HS, Raimundo JM,et al. Could high fat diet rich in unsaturated fatty acids impair the cardiovascular system?. Can J Cardiol. Descember 2010;26(10): 542-48.
- Kanthe PS, Patil BS, Bagali SC, Reddy RC, Aithala MR, Das KK. Protective effects of ethanolic extract of Emblica officinalis (amla) on cardiovascular pathophysiology of rats, fed with high fat diet. Journal of clinical and diagnostic research: JCDR. 2017 Sep;11(9):CC05.
- Rono DK. Effect of variable high fat diets on heart rate variability and selected modifiable cardiovascular risk factors.2013; University of Nairobi.
- Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H. Uncoupling of endothelial nitric oxide synthase in perivascular adipose tissue of diet-induced obese mice. Arteriosclerosis, thrombosis, and vascular biology. 2016 Jan;36(1):78-85.
- Nascimento TB, Baptista RD, Pereira PC, Campos DH, Leopoldo AS, Leopoldo AP, Oliveira Júnior SA, Padovani CR, Cicogna AC, Cordellini S. Vascular alterations in high-fat diet-obese rats: role of endothelial L-arginine/NO pathway. Arquivos brasileiros de cardiologia. 2011 Jul;97(1):40-5.
- Preeti Tiwari . Evaluation of Antihyperlipidemic Potential of Amritarishta Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 315-319 .
- Kumar V, Kshemada K, Ajith KG, Binil RS, Deora N, Sanjay G, Jaleel A, Muraleedharan TS, Anandan EM, Mony RS, Valiathan MS. Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy. Scientific reports. 2017 Aug 17;7(1):1-7.
- Desai SD, Patil BS, Kanthe PS, Potekar RM. Effect of ethanolic extract of Terminalia arjuna on liver functions and histopathology of liver in albino rats fed with hyperlipidemic diet. Int J Pharm PharmSci. 2015;7(10):302-6.
- Kanthe PS, Patil BS, Aithala MR, Das KK. Effect of ethanolic extract of Emblica officinalis (amla) on glucose homeostasis in rats fed with high fat diet. J. Krishna Inst. Med. Sci. Univ. 2017 Jul 1;6(3):31-7.
- Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: A review. International Pharmaceutica Sciencia 2011; 1:103-4.
- T. Sundarrajan, Vijey Aanandhi M. Hypolipidemic Activity of Amaranthus Tristis Linn in Triton WR-1339 Induced Hyperlipidemic Rats. Research J. Pharm. and Tech. 2017; 10(1): 171-173.
- Das KK, Dasgupta S. Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction. Environ Health Perspect 2012; 110 (9):923-26.
- Srivastava Vaibhav, Dubey Subodh, Singh Vigyan. Hypolipidemic activity of stem bark of Ailanthus excelsa Roxb in Triton WR 1339 induced hyperlipidemic rats. Research J. Pharm. and Tech. 2019; 12(3): 1338-1342.
- Preeti Tiwari. Antihyperlipidemic Potential of Balarishta Prepared by Traditional and Modern Methods in High Fat Diet Induced Hyperlipidemic rats. Asian J. Res. Pharm. Sci. 4(1): Jan.-Mar. 2014; Page 07-11.
- T. Sundarrajan, Vijey Aanandhi M.. Hypolipidemic activity of Alternanthera ficoidea Linn in Triton wr-1339 induced hyperlipidemic rats.Research J. Pharm. and Tech 2018; 11(2):687-689.
- Moshage H, Kok B, Huizenga JR, Jansen PL. Nitrite and nitrate determinations in plasma: a critical evaluation. Clinical chemistry. 1995 Jun 1;41(6):892-6.
- Poirier P, Hernandez TL, Weil KM, Shepard TJ, Eckel RH. Impact of diet induced weight loss on the cardiac autonomic nervous system in severe obesity. Obesity 2003 Sep1;11(9):1040-7.
- Lim K, Barzel B, Burke SL, Armitage JA, Head GA. Origin of aberrant blood pressure and sympathetic regulation in diet-induced obesity. Hypertension. 2016 Aug;68(2):491-500.
- Viktor V. Gorelik, Valery N. Vlasov. Assessment of Regulatory Systems Functional Reserves of the Handball Players at Exercises in the Training Process Dynamics. Research J. Pharm. and Tech. 2017; 10(3): 875-881.
- Sauder KA, Johnston ER, Skulas‐Ray AC, Campbell TS, West SG. Effect of meal content on heart rate variability and cardiovascular reactivity to mental stress. Psychophysiology. 2012 Apr;49(4):470-7.
- Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, Nishigaki I. The vascular endothelium and human diseases. International journal of biological sciences. 2013;9(10):1057.
- Jakulj F, Zernicke K, Bacon SL, Van Wielingen LE, Key BL, West SG, Campbell TS. A high-fat meal increases cardiovascular reactivity to psychological stress in healthy young adults. The Journal of nutrition. 2007 Apr 1;137(4):935-9.
- Kanthe PS, Patil BS, Khodnapur JP, Bagali SC, Mullur L, Aithala M. Comparative study of rate pressure product in obese women with nonobese women. Int J Biomed Adv Res. 2012;3:580-3.
- Preeti Tiwari and Rakesh K. Patel Evaluation of Antihyperlipidemic Potential of Drakshasava Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research J. Pharmacology and Pharmacodynamics. 2013; 5(2): 92-97.
- Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, Nishigaki I. The vascular endothelium and human diseases. International journal of biological sciences. 2013;9(10):1057.
- Patil BS, Kanthe PS, Reddy CR, Das KK. Emblica officinalis (Amla) Ameliorates High-Fat Diet Induced Alteration of Cardiovascular Pathophysiology. Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular and Hematological Agents). 2019 May 1;17(1):52-63.
- Sandoo A, van Zanten JJ, Metsios GS, Carroll D, Kitas GD. The endothelium and its role in regulating vascular tone. The open cardiovascular medicine journal. 2010;4:302.
- Amiya E, Watanabe M, Komuro I. The relationship between vascular function and the autonomic nervous system. Annals of Vascular Diseases. 2014;7(2):109-19.
- A. Julius, K. Renugadevi, V. Hemavathy. Effect of Oxidative Stress in Essential Hypertension. Research J. Pharm. and Tech. 7(12): Dec. 2014; Page 1400-1403.
- Khaliq F, Parveen A, Fahim M. Effect of Terminalia arjuna on heart rate variability in diabetic rats. Int J Curr Res Chem Pharma Sci. 2014;1:44-7.
- Kirti Rawal, Gaurav Sethi, B S Saini, and Indu Saini. Impact of the Menstrual Cycle on Heart Rate Variability. Research J. Pharm. and Tech 2019; 12(8):3854-3856.
- Acharya UR, Joseph KP, Kannathal N, Lim CM, Suri JS. Heart rate variability: a review. Medical and biological engineering and computing. 2006 Dec 1;44(12):1031-51.
- Miller AL. Botanical Influences on Cardiovascular Disease. Alternative Medicine Review 1998; 3(6): 422-31. 36. Yadav RN, Rathore K. A new Cardinolide from the roots of Terminalia Arjuna. Fitoterpia 2001; 72:459-61.
- Parveen A, Babbar R, Agarwal S, Kotwani A, Fahim M. Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. Cardiovascular toxicology. 2011 Mar 1;11(1):48-57.