Research Journal of Pharmacy and Technology

M. Manikumar ¹, R. Monisha ²

Affiliations
1 Saveetha College of Physiotherapy, Saveetha University, Chennai, IN
2 SRM College of Physiotherapy, SRMIST, Chennai, IN

Abstract

Introduction: Breast cancer is the most frequent‑occurring cancer among women and the leading cause deaths. Despite this Breast cancer treatments still have side effects that may negatively impact recovery and quality of life (QOL) after initial treatments. BCRL is a chronic swelling of the arm, hand and associated trunk quadrant. It usually develops after damage to the axillary lymph nodes due to breast cancer therapies. Methods: Participants who had fulfilled the eligibility criteria were randomized to either the aerobic exercise group (n = 20) and weight training group (n = 20). Exercise program was divided into a warm‑up period, moderate intensity of aerobic exercises, and cool‑down period. Weight-training exercise of low to moderate intensity with relatively slow progression significantly improved the upper limb strength, lower limb strength and incidence of breast cancer-related lymphoedema. Outcomes were assessed at baseline and post intervention. Results: Outcome were assessed by the functional assessment of cancer therapy‑breast (FACT‑B) scale and 6 min walk test (6MWT) Depressive symptoms are assessed using the CES-D scale. Upper limb musculoskeletal disorders is assessed using the DASH (Disabilities of the Arm, Shoulder, and Hand) The results confirmed the hypothesis that 12 week of moderate‑intensity aerobic exercise program significantly reduces BCRL. Conclusion: There have been many studies of resistance exercise in breast cancer survivors, Findings of this trial revels that aerobic exercise will contribute to the reduction of metabolic syndrome in best cancer survivors.

Keywords

BCRL, 6MWT, DASH, QOL, Aerobic Training.

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B. Usharani ¹, R. Monisha ¹

Affiliations
1 Department of Biochemistry, School of Life Sciences, VISTAS, Chennai, 600117, Tamil Nadu,, IN

Abstract

HeLa cells are broadly used for in-vitro studies in bringing out the medicinal value of plants against some dreadful diseases. From time immemorial, it is well proven that plant extracts play a vital role in treating many diseases including cancer. The plant extract contains copious varied phenolic compounds and flavonoids that are majorly responsible for its medicinal properties. In our study we have focused on the extraction of betel quid (betel leaves, areca nut and slaked lime in an appropriate proportion) using the solvent hexane. The hexane extract of the betel quid was evaluated for in vitro studies of apoptosis of HeLa cells. The results revealed that hexane extract of the betel quid at the maximum concentration of 200 μg/mL was very effective and only 20.89 % of cells were viable. The cytotoxic effect against HeLa cells was significant with IC₅₀ of 96.33μg/ml. Further studies can be done on concentrating the bioactive compounds responsible for the anticancer activity. The bioactive active compounds can be formulated in the treatment of cancer in the upcoming research.

Keywords

HeLa cells, Betel quid, Cytotoxic effect, Anticancer.

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