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Agrawal, Mohit
- A Study on Anti-inflammatory Activity of Stem Bark Extract of Holoptelea Integrifolia
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Authors
Affiliations
1 Department of Pharmacology, Rajiv Academy for Pharmacy, N.H-2, P.O. Chhatikara, Mathura, (U.P),, IN
2 Faculty of pharmaceutical sciences ,Rama University, Kanpur, IN
1 Department of Pharmacology, Rajiv Academy for Pharmacy, N.H-2, P.O. Chhatikara, Mathura, (U.P),, IN
2 Faculty of pharmaceutical sciences ,Rama University, Kanpur, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 77-81Abstract
Background: Holoptelea integrifolia has been used for a long time in traditional medicine to cure inflammatory pain. The goal of the current research was to consider the anti-inflammatory activity and phytochemicals study of both the extracts of the stem bark of Holoptelea integrifolia. Methods: Anti-inflammatory potential was figure out in Carrageenan and Histamine models at 200 mg/kg doses. Apart from this, we have evaluated parameters like paw edema body weight, locomotor activity, hematological, biochemical assessment, etc. Results: Qualitative chemical test investigation of both the extracts of H. integrifolia stem bark acknowledge the presence of proteins, amino acids, alkaloids, glycosides, tannins, and flavenoids. The 200 mg/kg, p.o dose of the extract showed remarked (P < 0.05) dose-dependent inhibition of edema formation. Both the ethanolic extract (200 mg/ kg, b. w) and aqueous extract (200 mg/ kg, b. w) of H. integrifolia stem bark showed remarked anti-inflammatory properties in comparison to reference drug Ibuprofen. In the Carrageenan model, the ethanolic extract has good anti-inflammatory activity than the aqueous extract. So, the ethanolic extract of stem bark of H. integrifolia is used to combat inflammation alone or with other conventional anti-inflammatory agents to treat different inflammatory disorders. Conclusion: Taken together, these results support the traditional use of Holoptelea integrifolia as a potent anti-inflammatory agent that may be proposed for the treatment of inflammatory pain.Keywords
Anti-inflammatory, Holoptelea integrifolia, Carageenan, Histamine, Flavanoids, Stem bark.
References
- Chilivari Alekhya, V. Alagarsamy. Anti-inflammatory and Anti-asthmatic activity of Ethanolic extract of Syzygium cumini plant bark. Research J. Pharm. and Tech. 2019; 9(3): 159-164.
- Sosa S, Balick MJ, Arrigo R, Esposito RG, Pizza C, Altinier GA. Screening of the topical anti-inflammatory activity of some Central American plants. J Ethnopharmacol, 2019; 9(3): 173-178.
- B.Meher, T.Satapathy, A.K. Sahu, K.K Ahirwar, PD Kasinath, and N.P Jain. Screening of methanolic of Euphorbia hirta Linn for Antiinflammatory Activity in Experimental Animals. Research J. Pharm. and Tech.. Oct-Dec.2010; 3(4): 1178-1184.
- Mohan H. “Textbook of Pathology”, Jaypee brother’s medical publishers Private Limited. New Delhi, 2010; 6th Edn.: pp.130
- . 5. Robbin SL and RS Cotran Ed. In Robbins Basic Pathology. 6th Ed Saunders Company, London; 1998.
- Hussain, S.P., Harris, C.C., Inflammation and cancer: An ancient link with novel potential. International Journal of Cancer, 2007; 121: 2373-2380.
- Showkat Ahmad Ganie and Surender Singh Yadav; Department of Botany, Maharshi Dayanand University, Rohtak, Haryana, India Hindawi Publishing Corporation BioMed Research International, 2020; 13(9): 4269-4273.
- D306-308.K. Sanghi, S.B. Joshi, Efficacy of an Ayurvedic Formulation in Rheumatoid Arthritis. Research J. Pharmacognosy and Phytochemistry 2010; 2(4):
- Showkat Ahmad Ganie and Surender Singh Yadav, Hindawi Publishing Corporation ;BioMed Research International 2020; 13(9): 4269-4273.
- Kokate C K, Purohit A P, Gokhale SB, et al. Pharmacognosy 45th edition, Nirali Prakashan Pune, 2010, pages 1-14.
- Debela A. Manual for Phytochemical Screening of Medicinal Plants. Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia, 2002; page 35-47.
- Ecobichon DJ. The Basis of Toxicology Testing. RC Press, New York, 1997; pp 43-86.
- Winter, C.A., E.A. Risley and G.W. Nuss, Carrageenan induced edema in the hind paw of the rat as as an say for anti-inflammatory drugs. Exp. Biol. Med., 1962; 111: 544-547.
- Evaluation of Anti-arthritic Activity of Leaves Extracts of Neolamarckia Cadamba
Abstract Views :77 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Rajiv Academy for Pharmacy, NH-2, P.O. Chhatikara, Mathura, (UP),, IN
2 Faculty of Pharmaceutical Sciences, Rama University, Kanpur, (UP),, IN
1 Department of Pharmacology, Rajiv Academy for Pharmacy, NH-2, P.O. Chhatikara, Mathura, (UP),, IN
2 Faculty of Pharmaceutical Sciences, Rama University, Kanpur, (UP),, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 873-877Abstract
Background: Rheumatoid arthritis is a major auto immune disorder of body and affects the various joints which may lead to physical disability. The leaves of Neolamarckia cadamba (family rubiaceae) have long been used traditionally to treat rheumatoid arthritis. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores its anti-arthritic mechanism and phytochemical analysis of ethanolic and aqueous extract of leaves of Neolamarckia cadamba. Methods: Anti-arthritic potential was evaluated through Complete Freund’s Adjuvant (CFA) induced arthritis rats model at 200 mg/kg/p.o doses of the ethanolic and aqueous extracts of Neolamarckia cadamba leaves using Diclofenac sodium as a standard drug. Apart from this we have evaluated parameters like paw edema, body weight, loco motor activity, hematological observations, and radiography etc. Results: The results revealed various arthritic protective mechanisms. Similarly plant exhibited dose dependent anti-arthritic effect with maximum activity observed at 200 mg/kg/ b.w/ p.o.. The results of Complete Freund’s Adjuvant (CFA) model depicted better protection against paw edema and body weight alterations. Also Neolamarckia cadamba leaves extracts remarkably altered locomotion of rats, and positive results were seen in hematological parameters and radiography. Additionally plant exhibited remarkable anti-oxidant activity. Moreover phytochemical analysis revealed polyphenols, anti oxidants and flavanoids. Conclusion: By deeply analyzing the obtained results and data our research work supports the traditional use of Neolamarckia cadamba leaves as a potential anti arthritic agent that may be proposed for rheumatoid arthritis treatment.Keywords
Rheumatoid arthritis, Complete freund’s adjuvant, Neolamarckia cadamba, Diclofenac sodium Flavanoids.References
- G. Sivakumar, G. Arihara Sivakumar, Rebecca. Evaluation of Anti-arthritic activity of Methanolic extract of Barleria prionitis on CFA induced rats. Asian J. Pharm. Tech. 2019; 9(3): 159-164.
- Sujata S. Sawant, Sangram S. Patil, Hemant S. Kandle, Manohar D. Kengar, Ganesh B. Vambhurkar, Mangesh A.Bhutkar. Development and characterization of Lornoxicam loaded microsponge gel for Rheumatoid arthritis. Asian J. Pharm. Tech. 2019; 9(3): 173-178.
- Spandana K, Varun Teja Chary, Shivani M. Rheumatoid Arthritis. Research J. Pharma. Dosage Forms and Tech. 2019; 11(2): 131-133
- D.K. Sanghi, S.B. Joshi. Efficacy of an Ayurvedic Formulation in Rheumatoid Arthritis. Research J. Pharmacognosy and Phytochemistry. 2010; 2(4): 306-308
- Suneel Kumar A, Venkatarathanamma. V, Nageswara Rao Tentu, Pavan Kumar Kota, K.Suneel Kumar, A. Vijayalakshmi. Anti-arthritic Activity of Annona Squamosa Leaves Methanolic Extract on Adjuvant Induced Arthritis in Rats. Res.J. Pharmacology & Pharmacodynamics. 2017; 9(2): 46-56.
- Rahul Kaushik, Jainendra Jain, Pallavi Rai, Yogesh Sharma, Virender Kumar, Akanksha Gupta. Pharmacognostical, Physicochemical and Preliminary Phytochemical studies of Anthocephalus cadamba (Roxb.) Leaves. Research J. Pharm. and Tech. 2018; 11(4): 1391-1397.
- Rubi V, Fatma C, Amit S. Neolamarckia Cadamba: A Comprehensive Pharmacological. Glob J Pharmaceu Sci. 2018; 6(4): 555691.
- B. Arirudran, V. Krishnan, US Mahadeva Rao. Preliminary Phytochemical Analysis and Isolation and Identification of active principle components of petroleum ether extract from leaves of Lawsoniainermis L. Research J. Pharm. and Tech. 2019; 12(8): 3629-3636.
- Balaji Sujitha, Kavasseri Ganesan Kripa. Anti-arthritic and anti-Inflammatory polyphenols from Caryota urens L:A Molecular Docking Analysis. Research J. Pharm. And Tech 2020; 13(9): 4269-4273.
- Suby Mary Samuel, K Pramod, E N Bijin, K C Ajithkumar, U S Jijith. Herbal Remnedies for Rheumatoid Arthritis. Res. J. Pharmacognosy & Phytochem. 2016; 8(1): 32-36.
- Chander Hass, Parveen Kumar, Dheeraj Rajak, S.K. Jain, Manish M. Evaluation of Analgesic and Anti-inflammatory Activity of Bark of Neolamarckia cadamba in Rodents. Research J. Pharm. And Tech. 2010; 3(4): 1178-1184.