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B. Mohammed, Mohammed
- The Oxidative Status in Children with Autism Receiving Melatonin
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1 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad, IQ
1 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad, IQ
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 338-342Abstract
Objectives: To determine the changes in the levels of Malondialdehyde (MDA) and antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) in autistic children receiving melatonin supplementation to evaluate its antioxidant role in autism. Methods: A follow-up study was carried out in the Department of therapeutics and clinical pharmacy, Baghdad College of Medical Sciences, Baghdad - Iraq. The study was performed on 55 autistic children who had recruited from several private institutions specialized in autistic children care, Baghdad, Iraq between June 2018 and November 2018. The levels of melatonin, MDA, SOD and CAT were measured in the serum of 55 patients before and after receiving melatonin supplementation for three months. Results: The results revealed statistically significant differences in the levels of melatonin, MDA, SOD and CAT between patients before and after receiving melatonin supplement. Furthermore, melatonin levels showed significant positive correlations with both SOD and CAT in addition to a significant positive correlation between SOD and CAT while MDA levels showed significant negative correlations with melatonin, SOD and CAT in autistic patients before and after receiving the supplement. Conclusions: Melatonin levels, CAT and SOD activity showed to be improved significantly by melatonin supplementation with a concomitant reduction in the levels of MDA as an indicator of a decrease in an oxidative stress in autistic children.Keywords
Autism, Melatonin, Malondialdehyde (MDA), Superoxide dismutase (SOD), catalase (CAT), oxidative stress, Reactive oxygen species, lipid peroxidation.
References
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- Exosome and Breast Cancer
Abstract Views :100 |
PDF Views:0
Authors
Affiliations
1 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad, IQ
2 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad –, IQ
3 Lecturer, College of Pharmacy, Al Maaqal University, Basra, IQ
1 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad, IQ
2 Assistant Lecturer, Department of Therapeutic and Clinical Pharmacy, Baghdad College of Medical Sciences, Baghdad –, IQ
3 Lecturer, College of Pharmacy, Al Maaqal University, Basra, IQ
Source
Research Journal of Pharmacy and Technology, Vol 15, No 3 (2022), Pagination: 1393-1397Abstract
Breast cancer is responsible for the death of millions of women worldwide every year. It is widespread in the world and Iraq that become a genuine problem for public health. Several clinical, diagnostic and pathological techniques have been introduced to get early detection of breast tumors. The uses of current known tumors markers have many limitations. New technique for diagnosis of breast cancer involve detection of extracellular vesicles (EVs) exosomes and its phosphoproteins as a product of cancer cells which represent a non-invasive liquid biopsy that may replace the invasive surgical method.Keywords
Breast cancer, Exosomes, Endosomes, Extracellular vesicles, Endosomal sorting complex required for transport (ESCRT) machinery.References
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