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Alhalabi, Marwan
- The Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid profile in vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients
Abstract Views :157 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1610-1614Abstract
Objective: This study aims to investigate the impact of combining calcium and vitamin D supplements with metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome (PCOS) women. Study design: A randomized, placebo-controlled clinical trial. Setting: Damascus University of Obstetrics and Gynecology Hospital and Orient Hospital, in Damascus, Syria. Materials and methods: Forty PCOS women with 25-hydroxyvitamin D<30 ng/mL were randomly assigned to take either metformin (1500 mg/daily) plus placebo or metformin (1500 mg/daily) plus calcium (1000 mg/daily) and vitamin D3 (6000 IU/daily) orally for 8 weeks. Fasting serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG) and non-HDL cholesterol (non-HDL) were detected at the baseline and after 8 weeks of intervention. Results: Of all participants, thirty-four completed the study. After 8 weeks of intervention, calcium and vitamin D levels increased significantly in the supplementation group, but no significant changes in the lipid profile were noticed in both groups. Conclusions: Adding calcium and vitamin D to metformin therapy had no superior effect on improving lipid profile in vitamin D deficient/insufficient subjects with PCOS.Keywords
Polycystic Ovary Syndrome, Lipid Profile, Calcium, Vitamin D, Metformin.
References
- Goodarzi MO et al. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology. 2011;7(4):219–31.
- Azziz R et al. Polycystic ovary syndrome. Nature Reviews Disease Primers. 2016; 2:16057.
- Krul-Poel YHM et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. European Journal of Endocrinology. 2013;169(6):853–65.
- Raja-khan N et al. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. American Journal of Physiology Endocrinology and Metabolism. 2011;301(1):E1–10.
- Foroozanfard F et al. Effects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes. 2015;123(4):215–20.
- Mohammadi E et al. Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pacific journal of clinical nutrition. 2012;21(4):511–8.
- Asemi Z et al. Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Molecular Nutrition & Food Research. 2014;58(7):1465–73.
- Wang H et al. Vitamin D and Chronic Diseases. Aging and disease. 2017;8(3):346–53.
- Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertility and Sterility. 2014;102(2):460–468.e3.
- Wehr E et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. European Journal of Endocrinology. 2009;161(4):575–82.
- Li HWR et al. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism: Clinical and Experimental. 2011;60(10):1475–81.
- Hahn S et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Experimental and Clinical Endocrinology & Diabetes. 2006;114(10):577–83.
- Mishra S et al. Hypovitaminosis D and associated cardiometabolic risk in women with PCOS. Journal of Clinical and Diagnostic Research. 2016;10(5): BC01-BC04.
- Patra SK et al. Vitamin D as a predictor of insulin resistance in Polycystic Ovarian Syndrome. Diabetes & Metabolic Syndrome. 2012;6(3):146–9.
- Pal L et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: secondary analysis of a multicenter randomized controlled trial. The Journal of Clinical Endocrinology & Metabolism. 2016;101(8):3027–35.
- Ott J et al. Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. European Journal of Endocrinology. 2012;166(5):897–902.
- Chaudhuri JR et al. Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects. Journal of Lipids. 2013; 2013:623420.
- Vinarova L et al. The mechanism of lowering cholesterol absorption by calcium studied by using an in vitro digestion model. Food and Function. 2016;7(1):151–63.
- Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs and Aging. 2004;21(1):7–17.
- Wehr E et al. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. Journal of Endocrinological Investigation. 2011;34(10):757–63.
- Raja-Khan N et al. High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial. Fertility and Sterility. 2014;101(6):1740–6.
- Irani M et al. Vitamin D supplementation decreases TGF-β1 bioavailability in PCOS: A randomized placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism. 2015;100(11):4307–14.
- Asemi Z et al. Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clinical Nutrition. 2015;34(4):586–92.
- The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility. 2004;81(1):19–25.
- Holick MF et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism. 2011;96(7):1911–30.
- Yildiz BO et al. Visually scoring hirsutism. Human Reproduction Update. 2010;16(1):51–64.
- Wehmeier K et al. Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3. Biochimica et Biophysica Acta. 2005;1737(1):16–26.
- Wang JH et al. Serum cholesterol and expression of ApoAI, LXRβ and SREBP2 in vitamin D receptor knock-out mice. Journal of Steroid Biochemistry and Molecular Biology. 2009;113(3–5):222–6.
- Abdel-Rehim WM et al. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes. Molecular and Cellular Biochemistry. 2018.
- Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid Profile in Vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients:A Randomized, Placebo-Controlled Clinical Trial
Abstract Views :152 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
1 Department of Pharmaceutics and Pharmaceutical Technology, Damascus University, Damascus, SY
2 Department of Embryology and Reproductive Medicine, Damascus University, Damascus, SY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2327-2332Abstract
Objective: This study aims to investigate the impact of combining calcium and vitamin D supplements with metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome (PCOS) women. Study design: A randomized, placebo-controlled clinical trial. Setting: Damascus University of Obstetrics and Gynecology Hospital and Orient Hospital, in Damascus, Syria. Materials and methods: Forty PCOS women with 25-hydroxyvitamin D < 30 ng/mL were randomly assigned to take either metformin (1500 mg/daily) plus placebo or metformin (1500 mg/daily) plus calcium (1000 mg/daily) and vitamin D3 (6000 IU/daily) orally for 8 weeks. Fasting serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG) and non-HDL cholesterol (non-HDL) were detected at the baseline and after 8 weeks of intervention. Results: Of all participants, thirty-four completed the study. After 8 weeks of intervention, calcium and vitamin D levels increased significantly in the supplementation group, but no significant changes in the lipid profile were noticed in both groups. Conclusions: Adding calcium and vitamin D to metformin therapy had no superior effect on improving lipid profile in vitamin D deficient/insufficient subjects with PCOS. The Clinical Trial Registration Number is NCT03792984.Keywords
Polycystic Ovary Syndrome, Lipid Profile, Calcium, Vitamin D, Metformin.References
- Goodarzi MO et al. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology. 2011;7(4):219–31.
- Azziz R et al. Polycystic ovary syndrome. Nature Reviews Disease Primers. 2016;2:16057.
- Krul-Poel YHM et al. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. European Journal of Endocrinology. 2013;169(6):853–65.
- Raja-khan N et al. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. American Journal of Physiology Endocrinology and Metabolism. 2011;301(1):E1–10.
- Foroozanfard F et al. Effects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes. 2015;123(4):215–20.
- Mohammadi E et al. Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Asia Pacific journal of clinical nutrition. 2012;21(4):511–8.
- Asemi Z et al. Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Molecular Nutrition & Food Research. 2014;58(7):1465–73.
- Wang H et al. Vitamin D and Chronic Diseases. Aging and disease. 2017;8(3):346–53.
- Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertility and Sterility. 2014;102(2):460–468.e3.
- Wehr E et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. European Journal of Endocrinology. 2009;161(4):575–82.
- Li HWR et al. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism: Clinical and Experimental. 2011;60(10):1475–81.
- Hahn S et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Experimental and Clinical Endocrinology & Diabetes. 2006;114(10):577–83.
- Mishra S et al. Hypovitaminosis D and associated cardiometabolic risk in women with PCOS. Journal of Clinical and Diagnostic Research. 2016;10(5):BC01-BC04.
- Patra SK et al. Vitamin D as a predictor of insulin resistance in Polycystic Ovarian Syndrome. Diabetes & Metabolic Syndrome. 2012;6(3):146–9.
- Pal L et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: secondary analysis of a multicenter randomized controlled trial. The Journal of Clinical Endocrinology & Metabolism. 2016;101(8):3027–35.
- Ott J et al. Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. European Journal of Endocrinology. 2012;166(5):897–902.
- Chaudhuri JR et al. Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects. Journal of Lipids. 2013;2013:623420.
- Vinarova L et al. The mechanism of lowering cholesterol absorption by calcium studied by using an in vitro digestion model. Food and Function. 2016;7(1):151–63.
- Reid IR. Effects of calcium supplementation on circulating lipids: potential pharmacoeconomic implications. Drugs and Aging. 2004;21(1):7–17.
- Wehr E et al. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. Journal of Endocrinological Investigation. 2011;34(10):757–63.
- Raja-Khan N et al. High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial. Fertility and Sterility. 2014;101(6):1740–6.
- Irani M et al. Vitamin D supplementation decreases TGF-β1 bioavailability in PCOS: A randomized placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism. 2015;100(11):4307–14.
- Asemi Z et al. Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clinical Nutrition. 2015;34(4):586–92.
- The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and Sterility. 2004;81(1):19–25.
- Holick MF et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism. 2011;96(7):1911–30.
- Yildiz BO et al. Visually scoring hirsutism. Human Reproduction Update. 2010;16(1):51–64.
- Wehmeier K et al. Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3. Biochimica et Biophysica Acta. 2005;1737(1):16–26.
- Wang JH et al. Serum cholesterol and expression of ApoAI, LXRβ and SREBP2 in vitamin D receptor knock-out mice. Journal of Steroid Biochemistry and Molecular Biology. 2009;113(3–5):222–6.
- Abdel-Rehim WM et al. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes. Molecular and Cellular Biochemistry. 2018.
- Abdel-Rehim WM et al. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes. Molecular and Cellular Biochemistry. 2018;450(1-2):105-112.