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Samudrala, Mahanthi
- A Review on Viperin Evoke Exponential Interferon Radical SAM Enzyme and Macrophages Inducibility to Treat Viral Infections
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Authors
Affiliations
1 Department of Pharmacy Practice, M. A. M College of Pharmacy, Kesanupalli, Narasaraopeta, AP, IN
1 Department of Pharmacy Practice, M. A. M College of Pharmacy, Kesanupalli, Narasaraopeta, AP, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3063-3067Abstract
Viral infections are one of the major health issues prevailing now a day. They demand new therapeutic strategies. Viperin is a virus inhibitory protein which is present in the endoplasmic reticulum of mammalian cells. Viperin is a member of radical S-adenosyl methionine and is a super family of enzymes. Viperin is an interferon inducible protein which involves in the inhibition of replication and budding of a wide range of both DNA and RNA viruses including chikungunyavirus, bunyamwera virus, tick-born encephalitis virus, influenza virus, human cytomegalo virus, west nile virus, hepatitis-C virus, sindbis virus, Japanese encephalitis virus, HIV and others. Viperin is an enzyme which helps in converting cytidine triphosphate (CTP) to 31-deoxy-3141-didehydro CTP (ddhCTP) so that the viral replication stops. CTP is very much essential for the viral replication. This mechanism occurs through S-adenosyl methionine (SAM) dependent radical mechanism which is similar to other members of the RS super family. In innate signaling Viperin plays a main role by both direct inhibition and replication and by budding and it destroys the actin cyto-skeleton which further leads to increase HCMV. It is an best example to determine the anti-viral property.Keywords
Interferon, Radical Sam, Macrophages, Viral Infections, Interferon, Endoplasmic Reticulum, Cytidine Triphosphate (CTP), And Interferon Stimulated Gene (ISG).
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