Research Journal of Pharmacy and Technology

Amrutha S. Kumar ¹, M. Sekar Babu ², M. Vijey Aanandhi ²

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamil Nadu, IN

Abstract

Objectives: To assess the impairment of health related quality of life in patients with Anorectal disease by evolving a Questionnaire. To evaluate the impact in the quality of life in patients with Anorectal disease. Methodology: This method involves prospective analysis of quality of life in men and women with anorectal disease. The study is carried out by the collection and documentation of general information of the patient regarding the disease.SF-12 Questionnaire: The SF-12 Health Survey includes 12 questions from the SF-36 Health Survey (Version 1). These include: 2 questions concerning physical functioning; 2 questions on role limitations because of physical health problems; 1 question on bodily pain; 1 question on general health perceptions; 1 question on vitality (energy/fatigue); 1 question on social functioning; 2 questions on role limitations because of emotional problems; and 2 questions on general mental health (psychological distress and psychological well-being). Results: The study was conducted among 100 patients .There is an extremely significant (P<0.0001) values were obtained when compared between pre counseling and post counseling phases of knowledge, attitude and perception scores. Conclusion: Hemorrhoids is a common anorectal disease condition seen in almost all the age group except for neonates. Seen from my study that quality of life of patients with hemorrhoids could be improved to some extend with good education regarding the disease.

Keywords

Hemorrhoids, Quality of Life, Anorectal Disease.

Full Text

     

T. Sundarrajan ¹, M. Vijey Aanandhi ²

Affiliations
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamil Nadu, IN

Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively low cost and locally available.plant has been selected for this study present study. The aim is to perform on anti-hyperlipidemic activity of ethanolic extract of leaves of Amaranthus tristis Linn against Triton wr-1339 induced hyperlipidemia in rats. Amaranthus tristis Linn administered a dose of 200mg/kg (p.o) to the triton induced hyperlipidemic rats. Amaranthus tristis Linn shows a significant decrease in the levels of serum cholesterol, phospholipids, triglyceride, LDL, VLDL and significant increase in the level of serum HDL level.

Keywords

Amaranthus tristis Linn, Hyperlipidemia. LDL, VLDL, HDL.

Full Text

     

Kamalraj Raji ¹, M. Vijey Aanandhi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamil Nadu, IN

Abstract

Regulatory Affairs in pharmaceutical industry is dealing with all aspects of government affairs and to fulfill the requirements of Pharma regulatory agency of the concerned nations and deals with obtaining the approval from license, development of a pharmaceutical product to manufacturing,drug approval process and registration of pharmaceutical products for sale and distribution in different regulated markets and for post marketing studies. The pharmaceutical companies must adhere to the legislations that require drugs to be developed, tested, trialed, and manufactured in accordance to the guidelines so that they are safe and patient's well - being is protected. This topic aims at reviewing about the basics of drug regulatory filing in pharmaceutical industry and to gain knowledge about the different aspects of introducing drug product(s) into USFDA/Europe regulated market.

Keywords

Regulatory Affairs, Filing and USFDA/Europe.

Full Text

     

C. N. Hemalatha ¹, K. Anbarasu ², M. Vijey Aanandhi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, IN
2 Department of Pharmacology, KMCH College of Pharmacy, Coimbatore, IN

Abstract

Cancer is one of the major diseases and challenging to medicinal system to produce potent and the site specific anti-cancer drugs. In this cancer studies up to now most of the synthetic drugs produce undesirable side effects. At the same time from plant source produce potent and safer anti-cancer drugs than compare to synthetic drugs. Cissus quadrangularis is an important medicinal plant belonging to the family Vitaceae. In this study, the qualitative phytochemical studies by using ethanol and chloroform extracts, Toxicological studies by Acute toxicities studies (LD₅₀), Pharmacological Evaluations of Anti-tumor activity and Biochemical parameters are estimated and Anti-Oxidant Assay of C.quadrangularis were evaluated. The secondary metabolites such as phenol, glycosides, tannins and flavonoids were present in the ethanolic extract of C.quadrangularis. The DMBA breast cancer model is a well-known animal carcinogenesis model. CQ extracts possesses anti-tumor property as evidenced by its significant inhibition in the formation of tumor induced by chemical carcinogen (DMBA). From the results , it can be concluded that chloroform&amp;ethanolic extract of CQ restored the biochemical imbalance occurred due to DMBA administration as well as lowered the tumor incidences and burden, the results obtained with the ethanolic extract were promising as compared to that of chloroform extract. Thus it may be useful for the treatment of mammary carcinoma and associated complications such as oxidative damage.

Keywords

Cissus quadrangularis (CQ), Breast Cancer, 7, 12-dimethylbenz[α]anthracene (DMBA), Anticancer, In-vitro, Phytochemistry.

Full Text

     

P. Ranadheer Chowdary ¹, D. Praveen ¹, M. Vijey Aanandhi ²

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, IN
2 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, IN

Abstract

Background: Diabetes Mellitus is a metabolic syndrome characterized by increased blood sugar levels in the body. Dyslipidemia in diabetes is one of the most important reasons for silent heart attacks. The main aim and Objectives of this study are to evaluate the incidence of dyslipidemia after the diagnosis of Diabetes mellitus

Methodology: A prospective non interventional single centred study was carried out in a tertiary care hospital. A specially designed proforma was used to collect the data from the case sheets such as patient demographics. Lipid profile values were obtained from the patient after obtaining written consent from each patient and correlated with American Dyslipidemic Associations standard values. The incidence rate was calculated.

Results: We have included 500 patients in this study. We also observed that there were isolated, combined and mixed patterns of dyslipidemia in Diabetes Mellitus. The incidence rate was found to be 45.60%. Although there was no significant difference between the incidence rate of men and women.

Conclusion: Dyslipidemia in Diabetes Mellitus possess a major threat of myocardial risk and heart attacks. As HbA₁C is monitored every 3 months we recommend the monitoring of lipid profile test also every 3 months. Regular monitoring of Lipid Profile is an important way to prevent silent heart attacks.

Keywords

Incidence, Dyslipidemia, Diabetes Mellitus.

Full Text

     

D. Pavithra ¹, D. Praveen ², M. Vijey Aanandhi ³

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, IN
2 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University, Chennai, IN
3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, IN

Abstract

The misuse of drugs which are taken through intravenously have been a cause in youngsters which would lead to major health disorders that could increase the morbidity and mortality rate to an higher ratio following complications, infections and permanent health disorders. The introduction of mind-altering substances into body through intravenous needle reports to addiction which is a source for unending complications causing higher death rates. Certain drugs are injected into muscles, under skin or directly into the vein, where tack marks can be seen which would be a sign for chronic intravenous drug use. Collapsed vein is the common effect due to intravenous drug use. Cocaine, heroin, crystal methamphetamine, amphetamines, opiates and prescription drugs are used among IV users. Prescription drugs are taken via injection illegally including barbiturates to hydrocodone, consuming them for certain reason other than for what they are prescribed for and with altered dose along with altered route of administration. Due to rapid onset of action the addicts prefer intravenous method for induction of drugs into their body. Major complications could be faced by IV drug abusers which includes severe blood-borne diseases, infections, abscesses, collapsed veins, increased chance of over dose since intravenous administration has rapid onset of action which bypasses body's detoxifying system. patient Counselling remains as best treatment to addicts which would help them to get rid of the habit followed by the infectious disease that are due to misuse of drug could be treated with appropriate antibiotics along with antiviral drugs depending on the type of infection they have undergone. A comprehensive literature search has been carried out in PubMed, Google Scholar, and articles pertaining to complications of intravenous drug use were selected for review.

Keywords

Drug Abuse, Intravenous, Complications.

Full Text

     

S. Ramachandran ¹, M. Vijey Aanandhi ¹, M. Tamilselvam ¹, V. Sursha ¹, K. T. Vigneshwara ¹

Affiliations
1 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai 600117, IN

Abstract

Schiff base or imine is an analogue of a ketone or aldehyde in which the carbonyl group has been replaced by an imine or azomethine group. Schiff bases exhibits a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties Imine or azomethine groups are present in various natural, natural-derived and non-natural compounds. The imine group present in such compounds has been shown to be critical to their biological activities A new compound (Z)-N_(4-dimethylamino) benzylidene) pyrimidine-2-aminewas synthesized by the reaction of 2-aminopyrimidine, 4-(dimethylamino) benzaldehyde and a drop of acetic acid in the presence of ethanol respectively. The chemical structures of the synthesized compounds were characterised by using Fourier Transform Infra Red Spectroscopy (FTIR), Proton Nuclear Magnetic Resonace Spectroscopy technique (1HNMR). The synthesized compound showed mild antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords

Antibacterial, Aromatic Aldehyde, 2-Amino Pyrimdine, Schiffbase, Imine.

Full Text