Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sreenivasa Reddy, M.
- Solubility Enhancement of Lumefantrine by Hot Melt Extrusion Process
Abstract Views :157 |
PDF Views:0
Authors
Rakshith Shetty
1,
Vaishnavi Tallapaneni
2,
M. Sreenivasa Reddy
2,
Nayanabhirama Udupa
2,
Srinivas Mutalik
2,
Vijay Kulkarni
1,
Vinay Rao
1,
Aravind Kumar Gurram
1
Affiliations
1 STEER Life India Pvt Ltd, Bengaluru 560058, Karnataka State, IN
2 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, IN
1 STEER Life India Pvt Ltd, Bengaluru 560058, Karnataka State, IN
2 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2929-2935Abstract
Lumefantrine is a BCS class -II drug having a poor aqueous solubility. There is a need for improvement in solubility, in order to enhance the therapeutic efficacy and reduce the dose. Hence in the present work, the solubility of lumefantrine is enhanced by formulating solid dispersions of lumefantrine using a hot melt extrusion process in a twin-screw processor using three different polymers such as Kollidon VA64, Soluplus and HPMC AS at a weight ratio of 1:2, 1:3 and 1:4, processed at different barrel temperatures and screw speeds. The obtained solid dispersions were characterized by differential scanning calorimetry and solubility studies. Solid dispersions prepared with KollidonVA64 and Soluplus showed a clear extrudate indicating a complete amorphous conversion of the lumefantrine at all the three ratios evaluated. Increase in polymer concentration, increased the solubility of the lumefantrine. With Kollidon VA 64 and Soluplus, lumefantrine to polymer ratio of 1:4 showed the highest increase in solubility, compared to that of the pure lumefantrine.Keywords
Lumefantrine, Polymers, Twin Screw Extrusion, Solid Dispersion, Solubility.
References
- Fule R, Meer TA, Sav A, Amin P. Solubility and dissolution rate enhancement of lumefantrine using hot melt extrusion technology with physicochemical characterisation. Journal of Pharmaceutical Investigation. 2013 Aug 1;43.
- Kolter K, Karl M, Gryczke A. Hot-Melt Extrusion with BASF Pharma Polymers. :201.
- Maniruzzaman M, Boateng JS, Snowden MJ, Douroumis D. A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products [Internet]. International Scholarly Research Notices. 2012 [cited 2018 Aug 29]. Available from: https://www.hindawi.com/journals/isrn/2012/436763/
- Patil H, Tiwari RV, Repka MA. Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation. AAPS Pharm SciTech. 2015 Jul 10; 17(1):20–42.
- Enose AA, Dasan PK, Sivarama krishnan H, Shah SM. Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection [Internet]. Journal of Pharmaceutics. 2014 [cited 2018 Aug 29]. Available from: https://www.hindawi.com/journals/jphar/2014/105382/
- Malaria: Symptoms, treatment, and prevention [Internet]. Medical News Today. [cited 2018 Aug 29]. Available from: https://www.medicalnewstoday.com/articles/150670.php
- Jain JP, Leong FJ, Chen L, Kalluri S, Koradia V, Stein DS, et al. Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers. Antimicrobial Agents and Chemotherapy. 2017 Sep 1;61(9):e00868-17.
- MA091part4v1.pdf [Internet]. [cited 2018 Aug 19]. Available from: https://extranet.who.int/prequal/sites/default/files/documents/MA091part4v1.pdf
- Coartem (Artemether Lumefantrine Tablets): Side Effects, Interactions, Warning, Dosage & Uses [Internet]. Rx List. [cited 2018 Nov 27]. Available from: https://www.rxlist.com/coartem-drug.htm
- Gryczke A. Solid Dispersions by Hot-Melt Extrusion [Internet]. [cited 2018 Aug 15]. Available from: http://www.pharmtech.com/solid-dispersions-hot-melt-extrusion