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Patel, Kritika
- Development and Validation of Diclofenac Sodium in Tablets using Simple UV Spectrophotometric Method
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1 Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, IN
1 Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 611-614Abstract
An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 μg/ml and the correlation coefficient (r²) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885μg/Ml and 0.250μg/mL respectively. Sandel’s sensitivity was found to be 0.000002 μg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.Keywords
UV Spectrometry, Diclofenac Sodium, Tablets, Validation, ICH Guidelines.
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