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Kumar, Hemanth
- Estimation of Lopinavir by RP-HPLC
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1 NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be university) Paneer, Deralakatte-575018, IN
1 NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be university) Paneer, Deralakatte-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 251-253Abstract
Simple, sensitive and accurate HPLC method has been developed for the estimation of Lopinavir in pharmaceutical dosage forms. Lopinavir is an antiretroviral drug. Chromatographic separation was conducted on phenomenex lunar (250x4.6mm, 5μ) column at temperature 35˚C, using a mobile phase composition of Acetonitrile: Water (70:30). The flow rate was 1ml/min and effluent was monitored at 198nm. The proposed method was validated as per the ICH guidelines. Evaluation of all the validation parameters suggested that the acceptance criteria were met. The proposed method can be used for routine analysis for the estimation of Lopinavir.Keywords
RP-HPLC, Lopinavir, Validation.
References
- https://medlineplus.gov.drug info.meds.
- Barragan P1, Podzamczer D. Lopinavir/ritonavir: a protease inhibitor combination;Pubmed,2008, Sep;9(13):2363-75
- A. suneetha, S. Kathirvel and G. Ramachandrika, “ A validated RP-HPLC method for simultaneous estimation of Lopinavir and Ritonavir in combined dosage form”, International Journal OF Pharmacy and Pharmaceutical Sciences, vol-3, issue-1, 2011: 49-51
- StefaniaNotari, AlessioBocedi, Giuseppe Ippolito, Pasquale Narciso, Leo Paldo, Paolo Pucillo, GiannaTossini, RaffaelePerroneDonnorso, Francesco Gasparrini, Paolo Ascenzi, “ Simultaneous determination of 16 anti HIV drugs in human plasma by high performance liquid chromatography”, J Chromatogr B AnalytTechnol Biomed Life Sci. vol-831, issue – 1-2 , February 2006: 258-266
- Rahul Vats, AdityaNarasimhaMurty and PunnaRao Ravi, “ Simple rapid and validated LC determination Lopinavir in rat plasma and application in pharmacokinetic studies”, ScientiaPharmaceutica vol-79, issue-4, September 2011: 859-864
- S. Mohan Varma, R. Vijayalakshmi, MD. Dhanaraju, “ Development and validation of RP-HPLC method for determination of Lopinavir in bulk and pharmaceutical dosage form”, International Journal of Reasearch in Pharmacy and Chemistry vol-2, issue-2, 2012: 413-417
- Guideline, I. H. T. (2005). Validation of analytical procedures: text and methodology Q2 (R1). IFPMA: Geneva.