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S Prabhu, Gayathri
- Protective Role of Dietary Choline and Docosahexaenoic Acid or Environmental Enrichment in Attenuating High Fat Diet-induced Arterial Wall Changes in Obese Rats
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Authors
Affiliations
1 Department of Physiology, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
2 Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
3 Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
4 Manipal School of Information Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
1 Department of Physiology, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
2 Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
3 Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
4 Manipal School of Information Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 665-670Abstract
Childhood obesity increases body mass index and long term metabolic disturbances. The present study is designed to analyze postnatal obesity-induced changes in body mass index and common carotid artery wall thickness and the role of dietary choline and DHA or environmental enrichment in mitigating these changes. Four groups of male rat pups (n=8/group) were assigned as Normal control (NC), Obese (OB) fed high-fat diet, Obesity-induced supplemented choline and DHA (OB+CHO+DHA) with 5mmol/kg/day of choline and 150 mg/ day of DHA, Obesity-induced environmental enrichment (OB+EE) exposed to environmental enrichment for 90 days. Body mass index was calculated after 90 days. Subsequently, rats were euthanized to excise common carotid artery. 5μ thick sections were processed for haematoxylin and eosin and Verhoff –Vangeison stains. Mean body weight, body mass index, thickness of tunica intima, media and percentage of collagen fibers in artery were significantly higher in OB group (p< 0.01, <0.001,< 0.01, < 0.001, < 0.05) as compared to the same in NC rats respectively. These changes were significantly (p<0.01, < 0.05) attenuated in OB+CHO+DHA and OB+EE groups compared to OB rats. Increased body mass index in early ages is an indicator for atherosclerosis. Supplementation of dietary choline and DHA or environmental enrichment exposure attenuates these changes from an early young age
Keywords
Childhood Obesity, Body mass index, Common carotid artery, Dietary nutrients, Enrichment.
References
- Sharma S, Talukdar B (2019) Protective Effects of Exclusive Breastfeeding against Childhood Obesity: Finding Evidences from India. J Obes Overweig 5(1): 104
- Nor Masitah Mohamed Shukri et.al. Awareness in Childhood Obesity. Research J. Pharm. and Tech 2016; 9(10):1658-1662.
- N. Vidula Sri. Relationship of waist-hip ratio and body mass index (BMI) to the blood pressure of individuals in Chennai Population. Research J. Pharm. and Tech. 8(7): July, 2015; Page 906-908.
- Gardener H et al. Mediterranean diet and carotid atherosclerosis in the Northern Manhattan study. Atherosclerosis. 2014;234(2):303–10.
- B. Reshmi, Gowri Sethu. A Study on Obesity among Children. Research J. Pharm. and Tech. 8(8): August, 2015; Page 1177-1178.
- Chan YK, Brar MS, Kirjavainen PV, et al. High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: a pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE-/- mice. BMC Microbiology. 2016 Nov;16(1):264.
- Lakshmi Prabha, M. Sankari. Role of Il-1 in Atherosclerosis. Research J. Pharm. and Tech 2018; 11(7): 3163-3166.
- Rajabi A Al, Castro GSF, Silva RP, Nelson RC, Thiesen A, Vannucchi H, et al. Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet. J Nutr. 2014;144(3):252–8.
- Bradbury J. Docosahexaenoic acid (DHA): An ancient nutrient for the modern human brain. Nutrients. 2011;3(5):529–54.
- Pedro Javier Rodríguez-Hernández et al. Impact of Omega-3 Fatty Acids Among Other Nonpharmacological Interventions on Behavior and Quality of Life in Children with Compromised Conduct in Spain, Journal of Dietary Supplements, (2020) 17:1, 1-12.
- Mun JG, Legette LL, Ikonte CJ, Mitmesser SH. Choline and DHA in maternal and infant nutrition: Synergistic implications in brain and eye health. Nutrients. 2019;11(5).
- Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012;202(949):326–33.
- Hase Y et al. Carotid artery disease in post-stroke survivors and effects of enriched environment on stroke pathology in a mouse model of carotid artery stenosis. Neuropathol Appl Neurobiol. 2019;44:1–17.
- Thomas Rajarethnem H et al. Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurol Res Int. 2017;2017.
- Gayathri S. Prabhu, Mohandas K. G. Rao & Kiranmai S. Rai. Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats– exploring the comparable benefits of choline and DHA or environmental enrichment. International Journal of Neuroscience, (2020).Published online 4th June 2020. (Article in Press)
- Duarte F et al. The effects of exercise modalities on adiposity in obese rats. Clinics. 2012;67(12):1469–77
- Novelli Filho JLVB et al. Anthropometrical parameters and markers of obesity in rats. Lab Anim. 2007;41(1):111–9.
- Kumar N et al. Quantitative fraction evaluation of dermal collagen and elastic fibres in the skin samples obtained in two orientations from the trunk region. Dermatol Res Pract. 2014;2014.
- Viggiano E et al. Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators. Front Cell Neurosci. 2016;10(June):1–8
- S K. Pramila, A. Julius. Antihyperglycemic, Antidyslipidemic and Antifibrotic effect of EGCG in STZ - High Fat Diet Induced DCM rats. Research J. Pharm. and Tech. 2019; 12(4): 1839-1842.
- Akram Ashames et al. Correlation between Neck Circumference, Waist Circumference, Body Mass Index, and Overweight/Obesity among Ajman University Students. Research J. Pharm. and Tech. 2019; 12(5):2443-2452.
- Balaji. V, V. Vishnu Priya, R. Gayathri. Awareness of risk factors for obesity among College students in Tamil Nadu: A Questionnaire based study. Research J. Pharm. and Tech. 2017; 10(5): 1367-1369.
- Takkella N et al. Role of choline-docosahexaenoic acid and trigonella foenum graecum seed extract on ovariectomy induced dyslipidemia and oxidative stress in rat model. J Krishna Inst Med Sci Univ. 2018;7(1):1–7
- Gao X, Wang Y et al. Higher Dietary Choline and Betaine Intakes are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada. PLoS One. 2016;11(5):1–17
- Tsai PP, Pachowsky U, Stelzer HD, Hackbarth H. Impact of environmental enrichment in mice. 1: Effect of housing conditions on body weight, organ weights and haematology in different strains. Lab Anim. 2002;36(4):411–9.
- Prashant S Mewada et al. New Emerging Targets for Obesity. Asian J. Research Chem. 3(2): April- June 2010; Page 278-287
- Kandukuri Lakshmi, S. Ramachandran. A Study of Physical Activity in Children and Adolescents. Research J. Pharm. and Tech 2017; 10(10):3605-3606.
- Park SH et al. Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus. Circulation. 2001;104(7):815–9
- Tsamis A, Krawiec JT, Vorp DA. Elastin and collagen fibre microstructure of the human aorta in ageing and disease: A review. J R Soc Interface. 2013;10(83). 30. Kavitha. D. Carotid Artery Stenosis. Int. J. of Advances in Nur. Management. 2020; 8(1): 100-102.
- Da Costa KA, Rai KS et al. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the pemt-/- mouse. J Biol Chem. 2010;285(2):1008–15.
- Gladine C, Zmojdzian M et al. The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR−/− mice. Genes Nutr. 2014;9(5).