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Mhaskar, Gauri M.
- Formulation and Evaluation of Zingiber officinale Emulgel
Abstract Views :157 |
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Authors
Affiliations
1 Department of Chemistry, Dnyanprassarak Mandal’s College and Research Centre, Assagao-Bardez, Goa, IN
1 Department of Chemistry, Dnyanprassarak Mandal’s College and Research Centre, Assagao-Bardez, Goa, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1294-1300Abstract
The main aim of this work was to formulate the extract obtained from Zingiber officinale (Ginger) in to an emulgel and study its microbial activity and different characterisation. methanolic extract of dried rhizome of Zingiber officinale were subjected to many tests to identify the required active constituent. Emulgel formulations were prepared using different concentration of gelling agents i.e sodium CMC. The influence of the different concentration of the gelling agent on the drug release from the prepared emulgel was investigated. The prepared emulgel were evaluated for their physical appearance, pH, Spreadability, in-vitro drug release, antimicrobial activity and stability. From the results it was found that the formulation F3 with 1.5g of Sodium CMC shows better drug release (98.22% at 8 h) and higher antimicrobial activity compared to other formulations. The present work focuses on the potential of extracts for topical antibacterial purposes.Keywords
Emulgel, Sodium CMC, Ginger.
References
- Doaa Yassen, Ammal Esmaeel Ibrahim; Antibacterial activity of crude extracts of Ginger (Zingiber officinale Roscoe) On Escherichia coli and staphylococcus aureus: A study in vitro Indo American Journal of Pharmaceutical Research 2016; 6(6): 5830-5835.
- Sk. Shaheda Sultana, G. Swapna, G. Sai Sri Lakshmi, S. Swathi, G. Nirmala Jyothi, A. Seetha Devi; Formulation and evaluation of herbal emulgel of Latana camara leaves extract for wound healing activity in diabetic Rats; Indo American Journal of Pharmaceutical Research 2016; 6(8): 6404-6417.
- Dr. Gaikwad DD, Shinde Sachin K, Kawade Ashwini V, Dr. Jadhav SJ and Dr. Gadhave MV: Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests: The Pharma Innovation Journal 2017; 6(2): 179-182
- Patel V. A, Makwana S. B, Patel B.A., Parmar S. J. Formulation and Characterization of Micro-emulsion based gel of Curcumin for the Management of Plaque Psoriasis Post Graduate Department of Pharmaceutical Sciences, Sardar Patel University Vallabh Vidhyanagar: 388120, Gujarat, INDIA
- Vikas Singla, Seema Saini, Baibhav Joshi and A.C Rana: “Emulgel: a new platform for topical drug delivery” International Journal of Pharma and Bio Sciences 2012; 3(1): 485-498.
- Mrinalini C. Damle , Mangesh R. Bhalekar and Sneha A. Lonkar: Formulation and evaluation of herbal emulgel for the treatment of psoriasis: World Journal Of Pharmacy And Pharmaceutical Sciences 2017: 6(7): 1199-1210.
- Arcot Ravindran Chandrasekaran, Chan Yoke Jia, Choong Sheau Theng, Teeba Muniandy, Selvadurai Muralidharan and Sokkalingam Arumugam Dhanara: In vitro studies and evaluation of metformin marketed tablets: Malaysia Journal of Applied Pharmaceutical Science 2011: 1(5): 214-217.
- S. Ramakrishna, V. Mihira, K. Raja Vyshnavi, V. Ranjith Design And Evaluation of drug release kinetics of meloxicam sustained release matrix tablets: International Journal of Current Pharmaceutical Research 2012; 4(1): 90-99.
- Snehal P. Mulye, Kiran A. Wadkar and Manish S. Kondawar: Formulation development and evaluation of Indomethacin emulgel: Pelagia Research Library 2013; 4(5): 31-45
- Venkateswara Rao, S., Vijaya Sri, P. and Padmalatha, K: Formulation and Evaluation of Oxiconazole Emulgel for Topical Drug Delivery: International Journal of Current Research 2017 9(10): 58876-58878.
- Vijay Kumar, Sheefali Mahant, Rekha Rao, Sanju Nanda: Emulgel based topical delivery system for loratadine: ADMET & DMPK 2014: 2(4); 254-271.
- Joshi Baibhav, Singh Gurpreet, Rana AC, Saini Seema: Development and Characterization of Clarithromycin Emulgel for topical delivery: International Journal of Drug Development & Research 2012; 4(3): 310- 323.
- Formulation and Evaluation of Ginger officinale Emulgel
Abstract Views :228 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Dnyanprassarak Mandal’s College and Research Centre, Assagao-Bardez, Goa, IN
1 Department of Chemistry, Dnyanprassarak Mandal’s College and Research Centre, Assagao-Bardez, Goa, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1559-1565Abstract
The main aim of this work was to formulate the extract obtained from Zingiber officinale (Ginger) in to an emulgel and study its microbial activity and different characterisation. methanolic extract of dried rhizome of zingiber officinale were subjected to many tests to identify the required active constituent. Emulgel formulations were prepared using different concentration of gelling agents i.e sodium CMC. The influence of the different concentration of the gelling agent on the drug release from the prepared emulgel was investigated. The prepared emulgel were evaluated for their physical appearance, pH, Spreadability, in-vitro drug release, antimicrobial activity and stability. From the results it was found that the formulation F3 with 1.5g of Sodium CMC shows better drug release (98.22% at 8 h) and higher antimicrobial activity compared to other formulations. The present work focuses on the potential of extracts for topical antibacterial purposes.Keywords
Emulgel, Sodium CMC, Ginger.References
- Doaa Yassen, Ammal Esmaeel Ibrahim; Antibacterial activity of crude extracts of Ginger (Zingiber Officinale Roscoe) On Escherichia coli and staphylococcus aureus: A study in vitro Indo American Journal of Pharmaceutical Research 2016; 6(6): 5830-5835.
- Sk. Shaheda Sultana, G.Swapna, G. Sai Sri Lakshmi, S. Swathi, G. Nirmala Jyothi, A. Seetha Devi; Formulation and evaluation of herbal emulgel of latana camara leaves extract for wound healing activity in diabetic rats; Indo American Journal of Pharmaceutical Research 2016; 6(8): 6404-6417.
- Dr. Gaikwad DD, Shinde Sachin K, Kawade Ashwini V, Dr. Jadhav SJ and Dr. Gadhave MV: Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests: The Pharma Innovation Journal 2017; 6(2): 179-182
- Patel V. A, Makwana S. B, Patel B.A., Parmar S. J. Formulation and Characterization of Micro-emulsion based gel of Curcumin for the Management of Plaque Psoriasis Post Graduate Department of Pharmaceutical Sciences, Sardar Patel University Vallabh Vidhyanagar: 388120, Gujarat, INDIA
- Vikas singla, seema saini, baibhav joshi and a.c rana: “Emulgel: a new platform for topical drug delivery” International Journal of Pharma and Bio Sciences 2012; 3(1): 485-498.
- Mrinalini C. Damle , Mangesh R. Bhalekar and Sneha A. Lonkar: Formulation and evaluation of herbal emulgel for the treatment of psoriasis: World Journal Of Pharmacy And Pharmaceutical Sciences 2017: 6(7): 1199-1210.
- Arcot Ravindran Chandrasekaran, Chan Yoke Jia, Choong Sheau Theng, Teeba Muniandy, Selvadurai Muralidharan and Sokkalingam Arumugam Dhanara: In vitro studies and evaluation of metformin marketed tablets: Malaysia Journal of Applied Pharmaceutical Science 2011: 1(5): 214-217.
- S.Ramakrishna, V.Mihira, K.Raja Vyshnavi, V.Ranjith Design And Evaluation of drug release kinetics of meloxicam sustained release matrix tablets: International Journal of Current Pharmaceutical Research 2012; 4(1): 90-99.
- Snehal P. Mulye, Kiran A. Wadkar and Manish S. Kondawar: Formulation development and evaluation of Indomethacin emulgel: Pelagia Research Library 2013; 4(5): 31-45
- Venkateswara Rao, S., Vijaya Sri, P. and Padmalatha, K: Formulation and Evaluation of Oxiconazole Emulgel for Topical Drug Delivery: International Journal of Current Research 2017 9(10): 58876-58878.
- Vijay Kumar, Sheefali Mahant, Rekha Rao, Sanju Nanda: Emulgel based topical delivery system for loratadine: ADMET & DMPK 2014: 2(4); 254-271.
- Joshi Baibhav, Singh Gurpreet, Rana AC, Saini Seema: Development and Characterization of Clarithromycin Emulgel for topical delivery: International Journal of Drug Development & Research 2012; 4(3): 310- 323.