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Authors
Affiliations
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
3 Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 687-692
Abstract
The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-β estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinoma
Keywords
Mammary Carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.
