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- Septiana P. Suciadi
- Alexander P. Nugraha
- Diah S. Ernawati
- Nurina F. Ayuningtyas
- Ida B. Narmada
- Aristika Dinaryanti
- Igo Syaiful Ihsan
- Eryk Hendrinto
- Helen Susilowati
- Fedik Abdul Rantam
- Sonny Perdana
- Darmawan Setijanto
- Diah Savitri Ernawati
- Rini Devijanti Ridwan
- David Buntoro, Kamadjaja
- Anita Yuliati
- Asti Meizarini
- Nike Hendrijantini
- Agung Krismariono
- Shafira Kurnia Supandi
- Tania Saskianti
- Ratri Maya Sitalaksmi
- Djoko Kuswanto
- Tansza Setiana Putri
- Nastiti Faradilla Ramadhani
- Muhammad Dimas Adiya Ari
- Alexander Patera Nugraha
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Prahasanti, Chiquita
- The Efficacy of Human Dental Pulp Stem Cells in regenerating Submandibular Gland Defects in Diabetic Wistar Rats (Rattus novergicus)
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Authors
Septiana P. Suciadi
1,
Alexander P. Nugraha
2,
Diah S. Ernawati
3,
Nurina F. Ayuningtyas
3,
Ida B. Narmada
2,
Chiquita Prahasanti
4,
Aristika Dinaryanti
5,
Igo Syaiful Ihsan
5,
Eryk Hendrinto
5,
Helen Susilowati
5,
Fedik Abdul Rantam
6
Affiliations
1 Universitas Airlangga, Surabaya, ID
2 Orthodontics Department, Universitas Airlangga, Surabaya, ID
3 Oral Medicine Department, Universitas Airlangga, Surabaya, ID
4 Periodontics Department, Universitas Airlangga, Surabaya, ID
5 Stem Cell Research and Development Center, Universitas Airlangga, Surabaya, ID
6 Virology and Immunology Laboratory, Microbiology Department, Universitas Airlangga, Surabaya, ID
1 Universitas Airlangga, Surabaya, ID
2 Orthodontics Department, Universitas Airlangga, Surabaya, ID
3 Oral Medicine Department, Universitas Airlangga, Surabaya, ID
4 Periodontics Department, Universitas Airlangga, Surabaya, ID
5 Stem Cell Research and Development Center, Universitas Airlangga, Surabaya, ID
6 Virology and Immunology Laboratory, Microbiology Department, Universitas Airlangga, Surabaya, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1573-1579Abstract
Chronic hyperglicemia in Diabetes Mellitus caused microangiopathy in salivary gland. Human Dental Pulp Stem Cells (HDPSCs) suspected can regenerate the defect. The aim of this study was to analyze the efficacy of HDPSCs in stimulating angiogenesis, acinar cell numbers and Transforming Growth Factor-β (TGF-β) serum to regenerate submandibular gland defects in diabetic Wistar rats. Twenty-four male Wistar (250-350 g) rats 3-months-old were used. Rats were divided into 4 groups (n=6 each: a positive control group on Day 7 (DM) (C+7), a positive control group on Day 14 (DM) (C+14), a treatment group on Day 7 (DM+5.105 HDPSCs transplantation intraglandular) (T7) and a treatment group on Day 14 (DM+5.105 HDPSCs transplantation intraglandular) (T14). Wistar Rats were administered with 30 mg of Streptozotocin per kg of bodyweight to induce Diabetes Mellitus (DM). Histopathological examination with HE staining was performed to analyse neovascularization and acinar cell numbers. ELISA was performed to measure TGF-β serum. Statistical analysis used: A Tukey HSD or Bonferroni test after ANOVA or Kruskal Wallis test was performed (p<0.05) based on a Saphiro Wilk and Levene’s test (p>0.05). The highest acinar cell number was found in the T7 group [513.167±136.17] with no significant difference [p=0.136, p<0.05]. The highest capillaries were found in T14 [10.667±4.54] and TGF-β serum level [168.87±37.38] with significant difference [p=0.006; p<0.05] and [p=0.008, p<0.05]. HDPSCs can regenerate submandibular gland defects in Diabetic Wistar rats by stimulating angiogenesis, acinar cells number and TGF – β serum.Keywords
Human Dental Pulp Stem Cells, Submandibular Gland Defect, Diabetes Mellitus, Acinar Cells, Angiogenesis, Transforming Growth Factor-β.References
- Nwauche KT, Monago Comfort C, Frank I. Management of Diabetes Mellitus with Combined Therapy of Reducdyn and Metformin in Streptozotocin-induced Diabetic Rats. Research J. Pharm. and Tech. 2014; 7(1): 39-43.
- International Diabetes Federation. Diabetes Atlas eight edition. Available from: URL: http://www.diabetesatlas.org, 2017.
- Basha SKH, Subramanian S. Antidyslipidemic Property of Annona Squamosa Leaves Extract Studied in Streptozotocin-Induced Experimental Diabetes in Rats. Asian J. Research Chem. 2012; 5(2): 234-238.
- Shrivastava SR, Shrivastava PS, Ramasamy J. Role of self-care in management of diabetes mellitus. J Diabet and Metab Dis. 2013; 12: 14.
- Ranadheer CP, Praveen D, Vijey AMA. Prospective Study on Incidence of Dyslipidemia in Diabetes Mellitus. Research J. Pharm. and Tech. 2017; 10(2):431-433.
- Kumari MS, Babu MK, Sulthana R, Srinivas M, Prasanthi C. Diabetes Mellitus: Present status and Drug Therapy Updates. Research J. Pharm. and Tech. 2014; 7(1):84-94.
- Gupta A, Chaturvedi P, Shrivastava S. K., Dubey P.K. Glitazones for the Treatment of Diabetes Type-2. Asian J. Research Chem. 2012; 5(2): 164-170.
- Salvayre NS, Pamplona A, Otin P. Hyperglycemia and Glycation in Diabetic Complications. Antioxid Redox Signal. 2009; 3071-3109.
- Pintor RM, Casanas Elizabeth, Serrano JG, Serrano J, Ramirez L, Arriba L, Hernandez G. Review Article Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients. Journal of Diabetes Research. 2012; 1-2.
- Randhika T, Ranganathan K. Original Research: Salivary Output in Type 2 Diabetic Patients. Oral Maxillofacial Pathology Journal. 2014; 1-2.
- Agarwal R, Lakshmi T. Salivary Enzymes as Biomarkers for Periodontitis – An Update. Research J. Pharm. and Tech. 2014; 7(1):98-100.
- Fatimah RN. Diabetes Mellitus Type 2. Faculty of Medicine Lampung University. 2015; 2-3.
- Soeharno H. The Effect of Glycemic Control on Periodontal Disease in Diabetic Patient. International Dental Journal. 2013; 1-2.
- Gusbi GAM, Mohamed S, El-Hafez SA. Submandibular Glands as an Evident of the Effects of Antioxidant on Alloxan Induced Diabetic Rats. World Journal of Medical Sciences. 2014; 210-216.
- Tao H, Han Z, Han ZC, Li Z: Review Article Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells International. 2016; 1314709: 1-11.
- Pedersen T, Blois A, Xue Y, Xing Z, Sun Y, Wistrand A, Lorens J, Fristad I, Leknes K, Mustafa K. Stem Cell Research and Therapy: Mesenchymal Stem Cells induce Endothelial Cell Quiescence and Promote Capillary Formation. Norway: Biomed Central. Stem Cell Res Ther. 2014; 17(5): 1-23.
- Gao F, Chiu SM, Motan DA. Mesenchymal stem cell and immunomodulation: current status and future prospects. Cell Death and Disease. 2016; 7(1): 62.
- Miran S, Mitsiadis TA, Pagella P. Innovative dental stem cell-based researchapproaches: the future of dentistry. Stem Cells International. 2016; 1 (1): 1-10.
- Nugraha AP, Narmada IB, Ernawati DS, Dinaryanti A, Hendrianto E, Ihsan IS, Riawan W, Rantam FA. Osteogenic potential of gingival stromal progenitor cells cultures in platelet rich fibrin is predicted by core-binding factor subunit-α1/Sox9 expression ratio (in vitro). F1000Research. 2018; 7(1134): 4.
- Furman BL. Streptozotocin-Induced Diabetic Models in Mice and Rats. Curr. Protoc. Pharmacol. 2015; 70 (5): 5471-54720.
- Knas M, Maciejzcyk M, Daniszewska I, Klimiuk A, Matczuk J, Kolodziej U, Waszkiel D, Ladny JR, Zendzian-Piotrowska M, Zalewska A. Oxidative Damage to the Salivary Glands of Rats with Streptozotocin-Induced Diabetes-Temporal Study: Oxidative Stress and Diabetic Salivary Glands. Journal of Diabetes Research. 2016; 3: 1-13.
- Mahmoud EF, Mahmoud MF: Effect of Pomegranate Peel Extract on Submandibular Salivary Glands of Streptozotocin-Induced Diabetes in Rats: Histological, Immunohistochemical and Ultrastructural Study. Journal of Advances in Biology and Biotechnology. 2017; 13 (3): 1-15.
- Jang JH, Lee HW, Shin HW, Kang MK, Park SH, Kim E. In vitro characterization of human dental pulp stem cells isolated by three different methods. Restorative Dentistry and Endodontics. 2016; 41 (4): 283-95.
- Luisi SB, Filho MSA, Pranke P. Isolation, immunophenotypic characterization and pluripotency of dental pulp stem cells. Dent Oral Craniofac Res. 2017; 3(5):1-3.
- Rantam FA, Nugraha AP, Narmada IB, Ernawati DS, Widodo ADW, Lestari P, Dinaryanti A, Hendrianto E, Ihsan IS, Susilowati H, Ertanti N, Karsari D. Gingival Mesenchymal Stem Cells from Wistar Rat’s Gingiva (Rattus Novergicus) – Isolation and Characterization (In Vitro Study). J Int Med Res. 2018; 11(2): 694-699.
- IBL International GMBH. TGF-β 1 ELISA Instructions for use. Hamburg Germany. 2017; 1-11.
- Emanuele C, Gordon P, Guy C. Regeneration of Acinar Cells following ligation of rat submandibular gland retraces the embryonic-perinatal pathway of cytodifferentiation. International Society of Differentiation. Published by Elsevier Ltd. 2010; 120 -130.
- Balaji S. Umbilical cord blood as a source of stem cells. Research J. Pharm. and Tech. 2015; 8(8): 1093-1095.
- Sasikala K. Education to Nursing Students on Collection, Preservation and Utilization of Cord Blood Stem Cells. Asian J. Nur. Edu. and Research. 2011; 1(4):113-116.
- Selvi ST. Stem Cell Therapy. Int. J. Adv. Nur. Management. 2017; 5(4): 361-364.
- Patyar DS. Role of Stem Cells in treatment of different Diseases. Research J. Pharm. and Tech 2018; 11(8): 3667-3678.
- Dauren S, Ahmet D, Kemal K, Mehmet T, Osman A. Local and systemic angiogenic and antiangiogenic response in rats after 70% hepatectomy.. Int J Clin Exp Pathol. 2017; 10(3): 2939-2949.
- Sakai T. Development and Regeneration of Salivary Gland Toward for Clinical Application. Oral Science International Elseiver. 2016; 13(1): 7-14
- Li Shiying, Gu Xiasong, Yi Sheng. The Regulatory Effects of Transforming Growth Factor-β on Nerve Regeneration.Cell Transplantation. 2017; 26(3): 381-394
- Park MS, Kim YH, Jung Y, Kim SH, Park JC, Yoon DS, Kim SH, Park JC, Yoon DS, Kim SH, Lee JW. In situ recruitment of human bone marrow-derived mesenchymal stem cells using chemokines for articular cartilage regeneration. Cell Transplant. 2015; 24(6): 1067
- Michalopuolos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol. 2010; 176: 2-13.
- Taniguchi E, Sakisaka S, Matsuo K, Tanikawa K, Sata M. Expression and Role of Vascular Endothelial Growth Factor in liver regeneration after partial hepatectomy in rats. J Histochem Cytochem. 2001; 49: 121-130.
- Laird DI, Von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008; 132: 612.
- Maring JA, van Meeteren LA, Goumans MJ, Ten DP. Interrogating TGF-beta function and regulation in endothelial cells. Methods Mol Biol. 2016; 1344: 193.
- Massague J. TGF-beta signaling in context. Nat Rev Mol Cell Biol. 2012; 13 (10): 616-646.
- Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, Dijke P. Identification of Smad7, a TGF-ß inducible antagonist of TGF-beta signaling. Nature. 1997; 389 (6651): 631-636.
- Shiying L, Xiasong G, Sheng Y. The Regulatory Effects of Transforming Growth Factor-β on Nerve Regeneration. Cell Transplantation. 2017; 26: 381-394.
- Ching-Shwun L, Zhong-Cheng X, Tom FL. Commonly Used Mesenchymal Stem Cell Markers and Tracking Labels: Limitations and Challenges. HHS Public Access. 2013; 28 (9): 1109–1116
- The Roles of Insulin Growth Factors-1 (Igf-1) in Bone Graft to Increase Osteogenesis
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Authors
Affiliations
1 Department of Periodontology, Faculty of Dental Medicine - Airlangga University, Surabaya,, ID
2 Student of Periodontic Residency Program, Faculty of Dental Medicine - Airlangga University, Surabaya, ID
1 Department of Periodontology, Faculty of Dental Medicine - Airlangga University, Surabaya,, ID
2 Student of Periodontic Residency Program, Faculty of Dental Medicine - Airlangga University, Surabaya, ID
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1737-1742Abstract
Background: Bone graft material is used with periodontal flap procedure that is expected to help the growth of new bone through the process of osteogenesis, osteoinduction, and osteoconduction. Some work must be done to support the regeneration of periodontal tissue, including the three key elements of principal, such as scaffolds (collagen and bone material), signal molecules (growth factors) and cells. IGF-1 is a growth factor that has been studied to stimulate the replication of osteoblasts and bone matrix synthesis of bone remodeling process. Osteocalcin is a specific product of osteoblasts, in a previous study that the increase of osteocalcin indicates an increase in bone formation markers. Osteopontin expression by kondrosit showed the role of these cell in sintesizing matrix that have a main role for osteoclast resorpsion dan bone remodeling. Objective: To know the effect of IGF-1 on bone healing process that has been applied xenograft with attention to osteoblast, osteoclast, osteopontin and osteocalcin expression in animal model. Methods: This study was an experimental study in the rabbit. Comparing two groups, xenograft + IGF-1 and others just xenograft, was applied to the tibia’s defect for 21 days. Results: There are significant differences between the groups. The expression of osteoblast, osteopontin and osteocalcin looks more numerous after 21 days on the xenograft + IGF-1 group than the group that only uses xenograft alone. Whereas expression of osteoclast was seen to be less in the xenograft + IGF-1 group. Conclusion: the use of IGF-1 as a fisiologic mediator in regenerate periodontal tissues proved to be effective with the increased expression of osteoblast, osteopontin, osteocalcin and decreased osteoclasts.Keywords
Bone graft, IGF-1, Bone remodelling, Osteoblast, Osteoclast, Osteopontin, Osteocalcin.References
- Christeena Abraham, Sankari Malaiappan, Savitha G. Association of Hematological and Periodontal Parameters in Healthy, Chronic and Aggressive Periodontitis Patients – A Cross Sectional Study. Research J. Pharm. and Tech 2019; 12(1): 74-78. doi: 10.5958/0974-360X.2019.00014.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-1-14;
- S. Mounika, Gopinath. Periodontitis as a Risk Factor of Atherosclerosis. Research J. Pharm. and Tech 2016; 9(11):2017-2019.
- S. Shreya, Gheena. The General Awareness among People about the Prevalence of Periodontitis. Research J. Pharm. and Tech. 8(8): August, 2015; Page 1119-1124. doi: 10.5958/0974-360X.2015.00196.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2015-8-8-29
- Sahar H. Al-Hindawi, Noori M. Luaibi, Batool H. Al-Ghurabi. Estimation of Alkaline Phosphatase level in the Serum and Saliva of Hypothyroid Patients with and without Periodontitis. Research J. Pharm. and Tech 2018; 11(7): 2993-2996. doi: 10.5958/0974-360X.2018.00551.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-7-50
- Rahendra Wira Hermawan, Ida Bagus Narmada, Irwadi Djaharu’ddin, Alexander Patera Nugraha, Dwi Rahmawati. The Influence of Epigallocatechin Gallate on the Nuclear Factor Associated T Cell-1 and Sclerostin Expression in Wistar Rats (Rattus novergicus) during the Orthodontic Tooth Movement. Research J. Pharm. and Tech. 2020; 13(4):1730-1734. doi: 10.5958/0974-360X.2020.00312.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-4-22)
- Fatima Malik Abood1, Ghassan A. Abbas HD. Conserv, Luma Jasim Witwit, Nada Khazal Kadhim Hindi, Halah Khaleel Ahmed Abu Khmra, Mohmmed R. Abid Ali. The occurrence of alveolar bone resorption with oral bacterial infection. Research J. Pharm. and Tech. 2017; 10(6): 1997-2000. doi: 10.5958/0974-360X.2017.00349.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-6-73
- Edman K, Öhrn K, NordstrÖm B, et al.: Trends over 30 years in the prevalence and severity of alveolar bone loss and the influence of smoking and socioeconomic factors–based on epidemiological surveys in Sweden 1983 – 2013. Int J Dent Hyg. 2015; 13(4): 283–291.
- Shaddox LM, Walker CB: Treating chronic periodontitis: Current status, challenges, and future directions. Clin Cosmet Investig Dent. 2010; 2: 79–91.
- Frencken JE, Sharma P, Stenhouse L, et al.: Global epidemiology of dental caries and severe periodontitis–a comprehensive review. J Clin Periodontol. 2017; 44 Suppl 18: S94–S105.
- Tonetti MS, Jepsen S, Corgel JO: Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action. J Clin Periodontol. 2017; 44(5): 456–462.
- Listl S, Galloway JS, Mossey PA, et al.: Global economic impact of dental diseases. J Dent Res. 2015; 94(10): 1355–6
- Divyadharsini V, Sankari M. Effect of Smoking on Interleukin- 1 and Reactive Oxygen Species in Periodontitis. Research J. Pharm. and Tech. 2018; 11(3): 1247-1250. doi: 10.5958/0974-360X.2018.00232.9 Available on: https://rjptonline.org/AbstractView.aspx?PID=2018-11-3-79
- Fianza Rezkita, Kadek G. P. Wibawa, Alexander P. Nugraha. Curcumin loaded Chitosan Nanoparticle for Accelerating the Post Extraction Wound Healing in Diabetes Mellitus Patient: A Review. Research J. Pharm. and Tech 2020; 13(2):1039-1042. doi: 10.5958/0974-360X.2020.00191.2 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-2-95
- Kumar P, Vinitha B, Fathima G. 2013. Bone grafts in dentistry. Bone Graft Dent.;5(1): 125-128. doi:10.4103/0975-7406.113312
- Saskianti T, Yualiartanti W, Ernawati DS, et al.: BMP4 expression following stem cells from human exfoliated deciduous and carbonate apatite transplantation on Rattus norvegicus. J Khrishna Institute Med Sci Uni. 2018; 7(2): 56–61.
- Jangid, M. R., Rakhewar, P. S., Nayyar, A. S., and Cholepatil, A. Bone Grafts in Periodontal Regeneration : Factors Impacting Treatment Outcome. Basic Research Journal of Medicine and Clinical Science.August 2, 2016. 106–109. Retrieved from http//www.basicresearchjournals.org
- Alexander Patera Nugraha, Fianza Rezkita, Martining Shoffa Puspitaningrum, Mahela Sefrian Luthfimaidah, Ida Bagus Narmada, Chiquita Prahasanti, Diah Savitri Ernawati, Fedik Abdul Rantam. Gingival Mesenchymal Stem Cells and Chitosan Scaffold to Accelerate Alveolar Bone Remodelling in Periodontitis: A Narrative Review. Research J. Pharm. and Tech 2020; 13(5):2502-2506. doi: 10.5958/0974-360X.2020.00446.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-76)
- Ari Triwardhani, Intan Oktaviona, Ida Bagus Narmada, Alexander Patera Nugraha. The Effect of Bifidobacterium Probiotic on Heat Shock Protein-70 Expression and Osteoclast Number during Orthodontic Tooth Movement in Rats (Rattus novergicus). Research J. Pharm. and Tech 2021; 14(3):1477-1481. doi: 10.5958/0974-360X.2021.00262.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-51
- Staines, K.A., MacRae, V.E., Farquharson, C. The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. J. Endocrinol. 2012; 214 (3), 241–255.
- Kim I, Song Y, Lee B, Hwang S. Human mesenchymal stromal cells are mechanosensitive to vibration stimuli. J Dent Res. 2012; 91: 1135–1140. doi: 10.1177/0022034512465291.
- Singh, S., Kumar, D. and Lal, A. K. ‘Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women’, Journal of Clinical and Diagnostic Research, 2015; 9(8): pp. RC04–RC07. doi: 10.7860/JCDR/2015/14857.6318.
- Yodthong, T., et al. l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/-Catenin Signaling Pathway. Mol. 2018; 23(12). http:// https://doi.org/10.3390/molecules23123086
- Kusuyama, J., Bandow, K., Ohnishi, T., Hisadome, M., Shima, K., Semba, I., Matsuguchi, T. Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase. Mol. Biol. Cell. 2017; 28(10): 1326–1336.
- Quan Yuan, Yan Jiang, Xuefeng Zhao, Tadatoshi Sato, Michael Densmore, Christiane Schüler, Reinhold G Erben, Marc D McKee, Beate Lanske Increased Osteopontin Contributes to Inhibition of Bone Mineralization in FGF23‐Deficient Mice. 2013. https://doi.org/10.1002/jbmr.2079
- Shipra Gupta, Shaveta Sood, and Aneet Mahendra. Gene therapy with growth factors for periodontal tissue engineering–A review, Med Oral Patol Oral Cir Bucal. 2011 Mar; 17(2): e301–e310. doi: 10.4317/medoral.17472
- Puspito Ratih Hardhani, Sri Pramestri Lastianny dan Dahlia Herawati. Pengaruh penambahan platelet-rich plasma pada cangkok tulang terhadap kadar osteocalcin cairan sulkus gingiva pada terapi poket infraboni. 2013. Jurnal PDGI. Vol. 62, No. 3, September-Desember l 2013, Hal. 75-82 | ISSN 0024-9548
- Amer Youssef, Doaa Aboalola and Victor K. M. Han. The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche. Stem Cells Int. 2017: 9453108. doi: 10.1155/2017/9453108
- Tao Qiu, Janet L. Crane, Liang Xie, Lingling Xian, Hui Xie and Xu Cao. IGF-I induced phosphorylation of PTH receptor enhances osteoblast to osteocyte transition. Bone Research 2018; 6: 5 https://doi.org/10.1038/s41413-017-0002-7
- Zhang Xiaoxuan, Helin Xing, Feng Qi, Hongchen Liu, Lizeng Gao and Xing Wang. Local delivery of insulin/IGF-1 for bone regeneration:carriers, strategies, and effects. Nanotheranostic. 2020 Sep 8; 4(4): 242-255. doi: 10.7150/ntno.46408
- Bi F, Shi Z, Liu A, Guo P, Yan S. Anterior cruciate ligament reconstruction in a rabbit model using silkcollagen scaffold and comparison with autograft. Plos ONE. 2015; 10(5): 1-15.
- Zhang Q, Yan S, Li M. Silk fibroin based porous materials. Materials 2009; 2: 2276-95.
- Saima S, Jan SM, Shah AF, Yousuf A, Batra M. Bone grafts and bone substitutes in dentistry. J Oral Res Rev. 2016; 8: 36-8
- Shoshana Yakar, Olle Isaksson. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. 2016; 26-32
- Xian L, Wu X, Pang L, Lou M, Rosen CJ, Qiu T, et al. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012; 18: 1095-101.
- Wang, T., Wang, Y., Menendez, A., Fong, C., Babey, M., Tahimic, C. G., et al. Osteoblast-specific loss of IGF1R signaling results in impaired endochondral bone formation during fracture healing. J. Bone. Miner. Res. 2015; 30: 1572–1584. doi: 10.1002/jbmr.2510
- Fang, Y., Xue, Z., Zhao, L., Yang, X., Yang, Y., Zhou, X., et al. Calycosin stimulates the osteogenic differentiation of rat calvarial osteoblasts by activating the IGF1R/PI3K/Akt signaling pathway. Cell Biol. Int. 2019; 43: 323–332. doi: 10. 1002/cbin.11102
- Eriksen, E. F. ‘Cellular mechanisms of bone remodeling’, Reviews in Endocrine and Metabolic Disorders, 2010; 11(4): pp. 219–227. doi: 10.1007/s11154-010-9153-1.
- Lucia Guerra-Menéndez, Maria C Sádaba, Juan E Puche, Jose L Lavandera, Luis F de Castro, Arancha R de Gortázar and Inma Castilla-Cortázar. J Transl Med. 2013; 11: 271. doi: 10.1186/1479-5876-11-271
- Sroga GE, Karim L, Colón W, Vashishth D. Biochemical characterization of major bone‐matrix proteins using nanoscale‐ size bone samples and proteomics methodology. Mol Cel Proteom. 2011; 11: M110.006718‐M110.006718. https://doi.org/ 10.1074/mcp.M110.006718
- Chen L, Zou X, Zhang RX, Pi CJ, Wu N, Yin LJ, Deng ZL. IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling. BMB Rep 2016; 49(2): 122–127.
- Carvalho, M. S., Cabral, J. M. S., da Silva, C. L., and Vashishth, D. Synergistic effect of extracellularly supplemented osteopontin and osteocalcinon stem cell proliferation, osteogenic differentiation, and angiogenicproperties. J. Cell Biochem. 2019; 120, 6555–6569. doi: 10.1002/jcb.27948
- Kahles, F.; Findeisen, H.M.; Bruemmer, D. Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes. Mol. Metab. 2014, 3, 384–393
- Paulo Roberto Camati and Allan Fernando Giovanini and Hugo Eduardo de Miranda Peixoto and Cassiana Majewski Schuanka and Maria Cecília Giacomel and Melissa Rodrigues de Araújo and João César Zielak and Rafaela Scariot and Tatiana Miranda Deliberador. Immunoexpression of IGF1, IGF2, and osteopontin in craniofacial bone repair associated with autogenous grafting in rat models treated with alendronate sodium. Clin Oral Invest 2015. DOI 10.1007/s00784-016-1975-0.
- Chai X., Zhang W., Chang B., Feng X., Song J., Li L., Yu C., Zhao J., Si H. GPR39 agonist TC-G 1008 promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Artif. Cells Nanomed. Biotechnol. 2019; 47: 3569–3576. doi: 10.1080/21691401.2019.1649270.
- Wei, W.;Liu, S.; Song, J.; Feng, T.; Yang, R.; Cheng, Y.; Li, H.; Hao, L. MGF-19E peptide promoted proliferation, differentiation and mineralization of MC3T3-E1 cell and promoted bone defect healing. Gene 2020; 749: 144703.
- Luukkonen, J., Hilli, M., Nakamura, M., Ritamo, I., Valmu, L., Kauppinen, K., et al. Osteoclasts secrete osteopontin into resorption lacunae during bone resorption. Histochem. Cell Biol. 2019; 151: 475–487. doi: 10.1007/s00418-019- 01770-y
- Singh, A., Gill, G., Kaur, H., Amhmed, M., and Jakhu, H. Role of osteopontin in bone remodeling and orthodontic tooth movement: a review. Prog. Orthod. 2018; 19: 18. doi: 10.1186/s40510-018-0216-2
- Tulika Tripathi, Prateek Gupta, Priyank Rai, Jitender Sharma, Vinod Kumar Gupta and Navneet Singh. Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators. Progress in Orthodontics volume 18. 2017. Article number: 30
- Crane Janet L. and Cao Xu. Function of Matrix IGF-1 in Coupling Bone Resorption and Formation. J Mol Med (Berl). February 2014; 92(2): 107–115. doi:10.1007/s00109-013-1084-3.
- Yakar Shoshana, Haim Werner and Clifford J Rosen. Insulin-like growth factors: actions on the skeleton. J Mol Endocrinol. 2018; 61(1): T115–T137. doi:10.1530/JME-17-0298.
- Utilization of Polymethyl Methacrylate and Hydroxyapatite Composite as Biomaterial Candidate for Porous Trabecular Dental Implant Fixture Development: A Narrative Review
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Authors
Chiquita Prahasanti
1,
Darmawan Setijanto
1,
Diah Savitri Ernawati
1,
Rini Devijanti Ridwan
1,
David Buntoro, Kamadjaja
2,
Anita Yuliati
1,
Asti Meizarini
1,
Nike Hendrijantini
2,
Agung Krismariono
2,
Shafira Kurnia Supandi
2,
Tania Saskianti
2,
Ratri Maya Sitalaksmi
2,
Djoko Kuswanto
3,
Tansza Setiana Putri
2,
Nastiti Faradilla Ramadhani
2,
Muhammad Dimas Adiya Ari
2,
Alexander Patera Nugraha
2
Affiliations
1 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya,, ID
2 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, ID
3 Design Product Engineering Department, Institute Technology Sepuluh November, Surabaya,, ID
1 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya,, ID
2 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, ID
3 Design Product Engineering Department, Institute Technology Sepuluh November, Surabaya,, ID
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1863-1869Abstract
Polymethyl Methacrylate (PMMA) and Hydroxyapatite (HA) utilization as single materials are rarely used as dental implant materials. There is a promising hope by combining these two materials as a dental implant fixture. Nevertheless, there is a limited information of PMMA/HA composite utilization as dental implant material. The aims of this narrative review is to describe the potential of PMMA/HA composite utilization as biomaterial candidate for porous trabecular dental implant fixture development. This narrative review finds the potential of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant. The keywords "Biomaterial," "Dental Implant," "Hydroxyapatite," "Osseointegration," and "Polymethyl Methacrylate" were used in a web-based search of PubMed, NCBI, Scopus, ScienceDirect, and ResearchGate databases. PMMA is non-toxic, cost-effective, biocompatible, simple to manipulate, and has strong mechanical properties in the oral cavity. Furthermore, osteoblastic cell adhesion, development, and differentiation are aided by the use of HA as a biomaterial to induce bone formation. Nonetheless, due to its rapid absorption and degradation, single HA is seldom used as a dental implant material. Developing dental implant composite has been extensively studied, among them are the fabrication of PMMA/HA. PMMA/HA has fairly good physical characteristics with a compressive strength, good bioaffinity properties, biocompatible with bone cells. The osteoconductivity of HA enhance the bioactivity of the composite materials, thus making the dental implant to have an excellent osseointegration. We propose that there is a possibility of utilization of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant fixture.Keywords
Biomaterial, Dental Implant, Hydroxyapatite, Osseointegration, Polymethyl Methacrylate.References
- Tyrovolas S, Koyanagi A, Panagiotakos DB, Haro JM, Kassebaum NJ, Chrepa V, Kotsakis GA. Population prevalence of edentulism and its association with depression and self-rated health. Sci Rep. 2016;6:37083.
- Peltzer K, Hewlett S, Yawson AE, Moynihan P, Preet R, Wu F, Guo G, Arokiasamy P, Snodgrass JJ, Chatterji S, Engelstad ME, Kowal P. Prevalence of loss of all teeth (edentulism) and associated factors in older adults in China, Ghana, India, Mexico, Russia and South Africa. Int J Environ Res Public Health. 2014;11(11):11308–11324.
- Pengpid S, Peltzer K. The prevalence of edentulism and their related factors in Indonesia, 2014/15. BMC Oral Health. 2018;18(1):118.
- Felton DA. Edentulism and comorbid factors. J Prosthodont. Feb; 2009 18(2):88–96.
- Hirai T, Ishijima T, Hashikawa Y, Yajima T. Osteoporosis and reduction of residual ridge in edentulous patients. J Prosthet Dent. Jan; 1993 69(1):49–56.
- Harsha L, Anand S. Literature Review on "Peek" Dental Implants. Research J. Pharm. and Tech 2016; 9(10):1797-1801
- Polzer I, Schimmel M, Müller F, Biffar R. Edentulism as part of the general health problems of elderly adults. Int Dent J. 2010 Jun;60(3):143-55. PMID: 20684439.
- Shah FA, Thomsen P, Palmquist A. Osseointegration and current interpretations of the bone-implant interface. Acta biomaterialia. 2019 Jan 15;84:1-5.
- Přikrylová J, Procházková J, Podzimek Š. Side effects of dental metal implants: impact on human health (metal as a risk factor of implantologic treatment). BioMed research international. 2019 Jul 10;2019.
- Goutam M, Giriyapura C, Mishra SK, Gupta S. Titanium allergy: a literature review. Indian journal of dermatology. 2014 Nov;59(6):630.
- Chaturvedi TP. Allergy related to dental implant and its clinical significance. Clinical, Cosmetic and Investigational Dentistry. 2013;5:57.
- Saini M, Singh Y, Arora P, Arora V, Jain K. Implant biomaterials: A comprehensive review. World Journal of Clinical Cases: WJCC. 2015 Jan 16;3(1):52.
- Kang BH, Ryu SC, Park HC. A study of the use of a hydroxyapatite and poly (methyl methacrylate) composite as a material for implants. Journal of Ceramic Processing Research. 2012;13(6):791-6.
- Teo AJT. Polymeric Biomaterials for Medical Implants & Devices Polymeric Biomaterials for Medical Implants and Devices. 2016.
- Basim SE, Mohammed RH. Al-Rubaie, Dawood SE. Studying the Affects of Salvia officinalis and Commiphora myrrha Extracts on Poly Methyl Methacrylate Acrylic (PMMA) and Flexible Acrylic Materials Exposed to Escherichia coli. Research J. Pharm. and Tech. 2019; 12(5):2407-2412.
- Lai W, Oka K, Jung, H. Advanced functional polymers for regenerative and therapeutic dentistry. 2015;550–557.
- Ali U, Karim KJBA, Buang NAA. Review of the Properties and Applications of Poly (Methyl Methacrylate) (PMMA). Polym. Rev. 2015; 55, 678–705.
- Zafar MS. Prosthodontic applications of polymethyl methacrylate (PMMA): An update. Polymers (Basel). 2020;12, 1–35.
- Alla KR. Conventional and Contemporary polymers for the fabrication of denture prosthesis: part I-Overview, composition and properties. Int. J. Appl. Dent. Sci. 1, 82–89 (2015).
- Arenas-Arrocena MC. New Trends for the Processing of Poly(Methyl Methacrylate) Biomaterial for Dental Prosthodontics. in Acrylic Polymers in Healthcare (2017).
- Deb S. Polymers in dentistry. Proc. Inst. Mech. Eng. Part H J. Eng. Med. 212, 453–464 (1998).
- Giavaresi G. Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/Glass composite implant: In vivo mechanical and histomorphometric assessments. Int. J. Artif. Organs 27, 674–680 (2004).
- Wijesinghe WPSL, Mantilaka, MMMGPG, Karunarathne TSEF, Rajapakse RMG. Nanoscale Advances methacrylate) nanocomposite using dolomite. 2019; 86–88.
- Ramesh S, Tan CY, Aw KL, Yeo WH, Hamdi M, Sopyan I, Teng WD. Sintering behaviour of hydroxyapatite bioceramics. Med J Malaysia. 2008;63:89-90.
- Singh S, Pal A, Mohanty S. Nano Structure of Hydroxyapatite and its modern approach in Pharmaceutical Science. Research J. Pharm. and Tech. 2019; 12(3): 1463-1472.
- Jang CH, Cho YB, Choi CH, Jang YS, Jung WK, Lee JK. 2014. Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration. Acta Otolaryngol. 134(3):255-9.
- Shi P, Liu M, Fan F, Yu C, Lu W, Du M. 2018. Characterization of natural hydroxyapatite originated from fish bone and its biocompatibility with osteoblasts. Mater Sci Eng C Mater Biol Appl. 90:706-712.
- Rincón-López JA, Hermann-Muñoz JA, Giraldo-Betancur AL, De Vizcaya-Ruiz A, Alvarado-Orozco JM, Muñoz-Saldaña J. Synthesis, Characterization and In Vitro Study of Synthetic and Bovine-Derived Hydroxyapatite Ceramics: A Comparison. Materials (Basel). 2018;25(3):11.
- Darwis D and Warastuti Y. Sintesis Dan Karakterisasi Komposit Hidroksiapatit (Ha) Sebagai Graft Tulang Sintetik. Jurnal Ilmiah Aplikasi Isotop dan Radiasi A Scientific Journal for The Applications of Isotopes and Radiation. 2008;4(2):144-54.
- Sato M, Sambito MA, Aslani A, Kalkhoran NM, Slamovich EB, Webster TJ. Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium. Biomaterials. 2006;27:2358-2369.
- Kasuga T. Coatings for metallic biomaterials. In: Niinomi, M. (Ed.), Metals for Biomedical Devices. Woodhead Publishing. 2010;11:260-282. 32. Dubok VA. Bio ceramics–yesterday, today, tomorrow. Powder Metall Met Ceram. 2010; 39:381–394.
- Hench LL, Thompson I. Twenty-first century challenges for biomaterials. JR Soc Interface. 2010;7(4): S379–S391.
- Aprilianti NA, Rahmadhani D, Rizqianti Y, Ramadhani NF,Nugraha AP. Periodontal ligament stem cells, solcoseryl pasta incoporated nano-hydroxyapatite silica gel scaffold for bone defect regeneration in chronic periodontitis: A Review. Biochemical and Cellular Archives, 2020;20:3101–3106
- Dorozhkin SV. Calcium Orthophosphates Applications in Nature, Biology and Medicine. Boca Raton, FL: Pan Stanford Publishing.
- Saskianti T, Nugraha AP, Prahasanti C, Ernawati DS, Suardita K, Riawan W. Immunohistochemical analysis of stem cells from human exfoliated deciduous teeth seeded in carbonate apatite scaffold for the alveolar bone defect in Wistar rats ( Rattus novergicus). F1000Res. 2020;22(9):1164.
- Prahasanti C, Nugraha Ap, Saskianti T, Suardita K, Riawan W, Ernawati DS. Exfoliated Human Deciduous Tooth Stem Cells Incorporating Carbonate Apatite Scaffold Enhance BMP-2, BMP-7 and Attenuate MMP-8 Expression During Initial Alveolar Bone Remodeling in Wistar Rats (Rattus norvegicus). Clinical, Cosmetic and Investigational Dentistry 2020:12 79–85.
- Bertazzo S, Zambuzzi WF, Campos DDP, Ogeda TL, Ferreira CV, Bertran CA. Hydroxyapatite surface solubility and effect on cell adhesion. Colloids Surf B Biointerfaces. 2010;78: 177–184.
- Saiz E, Gremillard L, Menendez G, Miranda P, Gryn K, Tomsia AP. Preparation of porous hydroxyapatite scaffolds. Mater Sci Eng C. 2007;27: 546–550.
- Sanchez–Sálcedo S, Arcos D, Vallet–Regi M. Upgrading calcium phosphate scaffolds for tissue engineering applications. Key Eng Mater. 2008;377: 19–42.
- Kattimani VS, Kondaka S, Lingamaneni KP. Hydroxyapatite Past, Present, and Future in Bone Regeneration. Bone and Tissue Regeneration Insights. 2016;7:9-19
- Choudhury, P. 2012. Nanomedicine || Hydroxyapatite (HA) coatings for biomaterials. 84–127.
- Nugraha AP, Rezkita F, Putra KG, Narmada IB, Ernawati DS, Rantam FA. Triad Tissue Engineering: Gingival Mesenchymal Stem Cells, Platelet Rich Fibrin and Hydroxyapatite Scaffold to ameliorate Relapse Post Orthodontic Treatment. Biochem. Cell. Arch. 2019; 19(2):3689-3693
- Balamurugan A, Kannan S, Rajeswari S. Bioactive sol-gel hydroxyapa- tite surface for Biomedical applications – in-vitro study, Trends in Biomaterials and Artificial Organs, 2002;16:18–20.
- Manso M, Jimenez C, Morant C, Herrero P, Martinez-Duart JM. Electrodeposition of hydroxyapatite coatings in basic conditions, Biomaterials, 2000;21:1755–61.
- Tsui YC, Doyle C, Clyne TW. Plasma-sprayed hydroxyapatite coatings on titanium substrates Part 2: optimization of coating properties, Biomaterials, 1998; 19:2031–43.
- Tanuja B. A complete review of dental implant materials. International Journal of Recent Scientific Research. 2018;9(11):29665-9. 48. Frazer RQ, Byron RT, Osborne PB, West KP. PMMA: An essential material in medicine and dentistry. Journal of long-term effects of medical implants. 2005;15(6):629-39.
- Alla RK, Raghavendra SKN, Vyas R, Tiruveedula NPB, Raju AMK. Physical and Mechanical Properties of Heat activated Acrylic Denture Base Resin Materials. Research J. Pharm. and Tech 2018; 11(6): 2258-2262
- Punet X, Mauchauffe R, Rodríguez-Cabello JC, Alonso M, Engel E, Mateos-Timoneda MA. Biomolecular functionalization for enhanced cell–material interactions of poly (methyl methacrylate) surfaces. Regenerative Biomaterials. 2015;2(3):167-75.
- Katschnig M, Maroh B, Andraschek N, Schlögl S, Zefferer U, Bock E, Leitinger G, Trattnig C, Kaufmann M, Balika W, Holzer C. Cell Morphology on Poly (methyl methacrylate) Microstructures as Function of Surface Energy. International Journal of Biomaterials. 2019;2019.
- Ding X, Takahata M, Akazawa T, Iwasaki N, Abe Y, Komatsu M, Murata M, Ito M, Abumi K, Minami A. Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface. Journal of Materials Science: Materials in Medicine. 2011;22(5):1247-55.
- Riihonen R, Nielsen S, Väänänen HK, Laitala-Leinonen T, Kwon TH. Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1. Matrix Biology. 2010;29(4):287-94.
- Kang BH, Ryu SC, Park HC. A study of the use of a hydroxyapatite and poly (methyl methacrylate) composite as a material for implants. Journal of Ceramic Processing Research. 2012;13(6):791-6.
- Kwon SY, Kim YS, Woo YK, Kim SS, Park JB. Hydroxyapatite impregnated bone cement: in vitro and in vivo studies. Bio-medical materials and engineering. 1997;7(2):129-40.
- Che Soh NHB, Pandian S. Reactions to Acrylic Resin in Orthodontic Patient. Research J. Pharm. and Tech. 2019; 12(3): 1397-1402.
- Harun WS, Asri RI, Sulong AB, Ghani SA, Ghazalli Z. Hydroxyapatite-based coating on biomedical implant. Hydroxyapatite: Advances in Composite Nanomaterials, Biomedical Applications and its Technological Facets. 2018:69-88.
- Jung JH, Kim SY, Yi YJ, Lee BK, Kim YK. Hydroxyapatite-coated implant: Clinical prognosis assessment via a retrospective follow-up study for the average of 3 years. The Journal of Advanced Prosthodontics. 2018;10(2):85.