Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Barik, Chandra Sekhar
- Formulation Development and Evaluation of Direct compressed Cefpodoxime proxetil Effervescent Tablets
Abstract Views :169 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack-754202, Odisha, IN
1 Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack-754202, Odisha, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2695-2699Abstract
Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class. It belongs to BCS class IV drugs and has a limited aqueous solubility of 0.4 mg/ml. Hence the present aim of the study is to enhance the solubility of Cefpodoxime proxetil through complexation with HP-β-cyclodextrin. Binary mixture of sodium bicarbonate and citric acid to be used as effervescent materials. The disintegration to be further enhanced using superdisintegrants such as croscarmellose sodium, sodium starchglycolate and polacrilin K. Seven such formulations were prepared with varying composition and proportion of superdisintegrants. All formulations indicated a fair weight variation with in the pharmacopoeial limit. The result varies from ±1.23% to ±3.58% against ±5%. Thickness range was determined between 4mm - 4.2mm. Hardness test result revealed a good strength of more than 4.5 kg/cm2 in every tablet. The percent friability was found within the specification. All formulation took fair time for completion of effervescence except F1 that don’t contain any superdisintegrant. Drug content of all formulations were found to be excellent with more than 98%. Formulation F7 showed excellent effervescent time as compare to other formulation. It showed a consistent drug release with more than 80 % drug released in just 30 minutes. In the FTIR spectra, presence of all significant peaks of drug and absence of any new peak in the formulations revealed that there was no interaction of drug with the excipients. Hence the present study could be an excellent approach to the delivery of the poorly soluble Cefpodoxime proxetil as effervescent tablet.Keywords
Cefpodoxime Proxetil, Effervescent Tablet, Superdisintegrants, Effervescent Time, In-vitro Dissolution.
References
- Anjugovind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB. Formulation and Evaluation of Mouth Dissolving Tablets of Deflazacort. Asian J. Pharm. Tech. 2016; 6(2): 91-98.
- Bibaswan Mishra, Prasanta Kumar Biswal, Nihar Ranjan Pani, Prasanna Kumar Dixit. In-vitro Characterization and Pharmacokinetic investigation of self-Micro-Emulsifying Tablets of Cinnarizine. Research J. Pharm. and Tech 2017; 10(10):3492-3497.
- WangL, Tang X. A novel ketoconazole bio adhesive effervescent tablet for vaginal delivery: design, in vitro and in vivo evaluation. International journal of pharmaceutics. 2008; 350: 181-187.
- Harald S. Effervescent dosage manufacturing. Pharmaceutical Technology Europe. 2003; 25–28.
- Liao Yet al. Inclusion complexes of HP-β-cyclodextrin with agomelatine: Preparation, characterization, mechanism study and in vivo evaluation. Carbohydrate Polymer. 2016; 147:415-425.
- Khan F, Katara R, and Ramteke S. Enhancement of Bioavailability of Cefpodoxime Proxetil Using Different Polymeric Microparticles. AAPS Pharm Sci Tech. 2010; 11(3): 1368–1375.
- S. M. Ragade, M. M. Bari, S. D. Barhate. Formulation and Evaluation of Candesartan Cilexetil Mouth Dissolving Tablet by using Natural Superdisintegrant. Asian J. Pharm. Res. 2018; 8(3): 136-144.
- Gangurde A. B., Bairagi V. A., Borse K. Design and Quality Control of fast Dissolving Atorvastatine Calcium and Amlodipine Besylate Tablets. Research J. Pharm. and Tech 2018; 11(6): 2424-2428.
- Johnny EAet al. Predicting orally disintegrating tablet formulations of ibuprofen tablets: An application of the new sedan-ODT expert system. European Journal of Pharmaceutics and Biopharmaceutics. 2012; 80: 638–648.
- Robert EL. Effervescent tablets, Key facts about a unique, effective dosage form. Amerilab Technologies, C.S.C. Publishing. 2001.
- Srinivasa Sastry D, Narayan a Charyulu R, Satyanarayana D S, Srilakshmi D. Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent. Research J. Pharm. and Tech. 2017; 10(3): 747-750.
- Venkatalakshmi Ranganathan, Ng Jeng Ho, Ravi Sheshala, Sasikala Chinnappan. Formulation and Characterization of Mouth Dissolving Tablets of Dexamethasone Using Synthetic Superdisintegrants. Research J. Pharm. and Tech 2018; 11(4): 1429-1435.
- Srinivasa DS, Narayana Charyulu R, Satyanarayana DS, Srilakshmi D. Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole. Research J. Pharm. and Tech. 8(10): Oct., 2015; Page 1389-1393.
- Khan Aet al. Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Saudi Pharmaceutical Journal. 2014; 22: 433–444.
- Patel AU et al. Shah Hot melt granulation method for the preparation of floating matrix tablets of Tolperison Hydrochloride. Future Journal of Pharmaceutical Sciences. 2018;4: 139-149.
- Bhagat B.V., Hapse S.A., Jadhav A.P., Gawand R.B. Mouth Dissolving Tablet: A Formulation Approach. Research J. Pharm. and Tech. 2017; 10(1): 355-361.
- Shivangi Shukla, Dinesh Kumar Mishra, Dinesh Kumar Jain. Designing of Fast Disintegrating Tablets for Antihypertensive Agent Using Superdisintegrants. Research J. Pharm. and Tech. 2016; 9(5): 527-532.
- Chowdary KPR and Hemavathi R. Formulation and dissolution rate studies on dispersible tablets of Ibuprofen. Indian journal of pharmaceutical sciences.2000; 62(3):213-216.
- Setty CM et al. Development of fast dispersible Aceclofenac tablets: Effect of functionality of superdisintegrants. Indian journal of pharmaceutical sciences. 2008; 70(2):180-85.
- Mutgalik S, Shetty RS and Manjunatha J. Formulation and evaluation of directly compressible dispersible tablets of Panchagnilavana. Indian journal of pharmaceutical sciences.2001; 63(2):128-131