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Mohan, Arti
- Formulation and Evaluation of Immediate Release Film Coated Tablets of An Anticancer Drug (Dasatinib)
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Authors
Arti Mohan
1,
G. Sangeetha
2
Affiliations
1 Depatment of Pharmaceutics, Krupanidhi College of Pharmacy, IN
2 Department of Pharmaceutics, Gautham College of Pharmacy, Bengaluru, Karnataka, IN
1 Depatment of Pharmaceutics, Krupanidhi College of Pharmacy, IN
2 Department of Pharmaceutics, Gautham College of Pharmacy, Bengaluru, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 729-734Abstract
Aim: The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentration of superdisintegrants with a view to obtain rapid action for myelogenous leukemia and acute lymphoblastic leukemia[1]. Dasatinib is a chemotherapy medication used to treat certain cases of leukaemia. Materials and Methods: Various formulations were prepared by direct compression technique using super disintegrants (cross carmellose sodium, sodium starch glyclote and crospovidone). Effect of different superdisintegrants on drug release was studied. Optimized formulation was selected on the basis of drug release and its in-vitro release profile compared with the reference product (Sprycel). Results and Discussion: The dissolution results showed gradient increase in the drug release with the increase in concentration of the super-disintegrants. Conclusion: Among all the formulations F3 containing croscarmellose sodium (4.5%) was found to show best results with 98.3% release within 45 minutes and it exhibited a release profile comparable to the reference product.Keywords
Dasatinib, Myelogenous Leukemia, Croscarmellose Sodium, Direct Compression Technique, Immediate Release.
References
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- Chinmaya keshari sahoo and D. Venkataramana. Formulation and Evaluation of Immediate release Tablets of Dasatinib using Croscarmelose sodium. Research Journal of Pharmacy and Technology 2017; 10(3):833-838.
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- A.K. Das, S. Bhanja, N. Srilakshmi. Formulation and evaluation of quetiapine immediate release film coated tablets , Asian Journal of Pharmaceutical and Clinical Research 2013; 6(3):107-112.
- Formulation and Evaluation of Interpenetrating Polymer Network Microparticles of Diclofenac Sodium
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Authors
Affiliations
1 Professor (Pharmaceutics), Arihant School of Pharmacy and Bio Research Institute, Adalaj, Gandhinagar,, IN
2 Assistant Professor, Dayanand Sagar University, Bangalore,, IN
1 Professor (Pharmaceutics), Arihant School of Pharmacy and Bio Research Institute, Adalaj, Gandhinagar,, IN
2 Assistant Professor, Dayanand Sagar University, Bangalore,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 792-798Abstract
Diclofenac sodium, a model anti-inflammatory drug, has adverse effects like gastric irritation and hepatic toxicity. To overcome these problems Interpenetrating Polymer Network microparticles can be used as a controlled drug delivery system. Preparation of Interpenetrating Polymer Network microparticles using two or more polymer is a novel approach as the polymers produce synergistic effect which could increase the mechanical strength and resilience of the microparticles. The aim of the study was to prepare Interpenetrating Polymer Network microparticles of Diclofenac Sodium using chitosan and Ghatti gum which were used to deliver Diclofenac Sodium to the intestine. Microparticles prepared by emulsion-cross-linking method using gluteraldehyde as a cross-linker were characterized by Fourier Transform Infrared Spectroscopy, Differential scanning calorimetry, Scanning electron microscopy and evaluated for in vitro dissolution rate. Fourier Transform Infrared Spectroscopy studies confirmed the absence of chemical interactions between drug, polymers and cross-linking agent. Differential scanning calorimetric results indicated amorphous dispersion of Diclofenac Sodium into Interpenetrating Polymer Network matrix. Scanning electron microscopy pictures showed that microparticles did not agglomerate and had a rough surface. Hydrated surface after swelling showed spongy porous surface which indicated the mechanism of drug release as diffusion. Particle size ranged between 294 to 366 μm. DS percentage encapsulation efficiency ranged from 84.09 to 96.81%. In vitro release studies indicated a dependence of drug release rates on both the amount of CS and GG used in preparation of microparticles. The release was extended up to 12 h and release rates indicated a non-Fickian and super case II mechanism.Keywords
Chitosan, Ghatti gum, Interpenetrating polymer networks, Microparticles, Hydrophillic polymers.References
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