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Sangal, Aditi
- Study of Antimicrobial activity of Star Anise Loaded Poly (DL-Lactide-Co-Glycolide) Nanoparticles
Abstract Views :172 |
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Authors
Vinod Kumari
1,
Aditi Sangal
1
Affiliations
1 Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313, IN
1 Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 499-507Abstract
Nanoencapsulation using polymeric material can be done for Star Anise as it increases its efficacy. Earlier studies reveal that nanoencapsulation increases the antimicrobial activity, bio availability of the plant extract. For preparing the Star Anise loaded poly (DL-lactide-co-glycolide) PLGA nanoparticles ‘solvent evaporation method’ was used. Solvent evaporation method is used for producing nanoparticles of small size (10 nm for Star Anise), high entrapment efficiency (88.53% for Star Anise) and also for the improvement of inhibition of microbial growth. Further morphology, drug loading, entrapment efficiency, release profile and antimicrobial activities of nanoparticles are characterized. Usually studies related to drug release are conducted in vitro at 37°C as the Star Anise shows the initial burst of 36% and it is followed by quite slow rate. During microbial analysis, the minimum inhibitory concentration(MIC) of Star Anise loaded nanoparticles against the Staphylococcus aureus and Bacillus pumilus shows the inhibition zone of 9.84 mm and 10.20mm respectively at 6000 ppm whereas in case of Pseudomonas aeruginosa and Escherichia coli the nanopaticles shows inhibition zone of 8.21mm and 7.21 mm respectively at 4000ppm.Nanoparticles prepared here in shows suitable sizes as well as morphology. Antimicrobial studies show that nanoparticles prepared are beneficial for food and biomedical applications. The main objective behind the work in hand is the preparation of Star Anise loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles for increasing the efficacy of antimicrobial activity related to Star Anise.Keywords
Star Anise, Antimicrobial Activity, Controlled Release, PLGA Nanoparticles, Anethole.
References
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- Synthesis, Characterization, Antimicrobial activity and Release Study of Cinnamon loaded poly (DL-lactide-co-glycolide) Nanoparticles
Abstract Views :163 |
PDF Views:0
Authors
Vinod Kumari
1,
Aditi Sangal
1
Affiliations
1 Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India), IN
1 Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India), IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1529-1535Abstract
Nanoscale drug delivery systems have shown their ability to encapsulate a variety of therapeutic agents. By encapsulating these molecules the solubility and stability of drug is improved. Cinnamon act as potential drug for lot of curable diseases such as Diabetes. For increasing its bioavailability as a drug, nanoencapsulation of cinnamon powder was carried out using solvent evaporation method. The effect of organic solvent and surfactant such as PVA (Polyvinyl alcohol) and Pluronic F-68 was studied. The morphology and particle size of nanoparticles was studied using Transmission Electron Microscopy (TEM) which shows nanoparticles of small size (10 nm for Cinnamon. Nanoencapsulation of Cinnamon also shows high entrapment efficiency (82.34% for Cinnamon) respectively and also improvement in inhibition of microbial growth. During microbial analysis, the minimum inhibitory concentration (MIC) of Cinnamon loaded nanoparticles against the Staphylococcus aureus and Bacillus pumilus shows the inhibition zone of 9.12 mm and 10.39mm respectively at 6000 ppm whereas in case of Saccharomyces cerevisiae and Candida albicans the nanopaticles shows inhibition zone of 7.23mm and 8.47 mm respectively at 4000ppm. Drug release study for cinnamon and corresponding nanoparticles was also done. The main objective behind the work in hand is the preparation of Cinnamon loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles for increasing the efficacy towards different ailments.Keywords
Bioavailability, Nanoparticles, Surfactants, Drug, Cinnamon, PLGA, PVA, Pluronic-68.References
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- U. D. Bret, N. S. Lakshmi, and C. T. Laurencin, “Biomedical Applications of Biodegradable Polymers,” J. Polym. Sci. Part B Polym. Phys., vol. 3, no. 49, pp. 832–864, 2011.
- M. Esfandyari-Manesh et al., “Study of antimicrobial activity of anethole and carvone loaded PLGA nanoparticles,” J. Pharm. Res., vol. 7, no. 4, pp. 290–295, 2013.
- Merlin NJ, Parthasarathy V, Manavalan R, Devi P, Meera R. Phyto-Physico chemical evaluation, Anti-Inflammatory and Anti microbial activities of Aerial parts of Gmelina asiatica. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 76-82.
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