Research Journal of Pharmacy and Technology

A. Vijayalakshmi ¹, M. Suganya ¹, Pankaj Kumar Giri ¹, S. Jayakumari ¹, P. Shanmugasundaram ¹

Affiliations
1 Department of Pharmacognosy, School of Pharmaceutical Sciences, VISTAS, Vels University, Pallavaram, Chennai-117, Tamilnadu, IN

Abstract

The present study aimed to evaluate anti-asthmatic activity of a classical Siddha formulation Seenthil chooranam (SC) by mast cell stabilizing effect and broncho dilator property by in-vivo method. Preliminary phytochemical and HPTLC analysis of SC were determined as per standard protocols. Phytochemical analysis of aqueous extract gave positive test for carbohydrates, phenols, glycosides, saponins, flavonoids, tannins and terpenoids. HPTLC finger print analysis of the aqueous extract showed the presence of possible number of components. The results of the in-vivo study demonstrate that SC has potent broncho dilator property with significant (p<0.001) mast cell stabilizing activity and decrease in leukocytosis in dose dependent manner. These findings are clearly indicative of the role of SC as potent inhibitor of mast cell degranulation and ability to control the leukocytosis, have bronchodilation and hence can be used for the management of asthma supporting the traditional claims.

Keywords

Seenthil Chooranam, Siddha Formulation, Asthma, Mast Cell.

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A. Vijayalakshmi ¹, Selvakannan A. Ajith SP ¹

Affiliations
1 School of Pharmaceutical Sciences, VISTAS, Vels University, Pallavaram, Chennai-117, Tamilnadu, IN

Abstract

The aim of the present study is to investigate the phytochemical and physiochemical investigation of a traditional classical Siddha formulation known as Seenthil chooranam (SC). Preliminary phytochemical analysis, HPTLC analysis and physicochemical parameters such as ash values, extractive values and loss on drying were determined as per standard protocols. The SC upon successive extraction with petroleum ether, chloroform, ethyl acetate and ethanol gave a yield of 0.05, 0.33, 1.50 and 1.90%w/w respectively. Phytochemical analysis of different extracts gave positive test for alkaloids, steroids, terpenoids, flavonoids, tannins, carbohydrates, glycosides, and proteins. HPTLC finger print analysis of the extracts showed the presence of possible number of components. Physicochemical parameters such as total ash, water soluble ash and acid insoluble ash values were found to be 2.98, 1.62 and 1.04%w/w, respectively; extractive value were found to be alcohol soluble 10.20 %w/w, water soluble- 10.24%w/w and moisture content– 0.105% w/w. The present study provides phytochemical and physicochemical details of SC which are useful in laying down standardization and pharmacopoeia parameters.

Keywords

Seenthil chooranam, Siddha Formulation, Standardization, HPTLC.

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A. Vijayalakshmi ¹, S. Sangeetha ², N. Ranjith ²

Affiliations
1 School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-117, Tamilnadu, IN
2 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, IN

Abstract

Chondromalacia patella (knee pain) is the softening and breakdown of the tissue (cartilage) on the underside of the kneecap (patella) and is often referred to as chondromalacia of the patella, patellofemoral syndrome, or runner's knee. Pain Results when the knee and the thigh bone (femur) rub together. Abnormal knee cap positioning, tightness or weakness of the muscles associated with the knee, too much activity involving the knee, and flat feet may increase the likelihood of chondromalacia patella. The undersurface of the patella is covered with hyaline cartilage that articulates with the hyaline cartilage covered femoral groove (trochlear groove). Post-traumatic injuries, microtrauma wear and tear, and iatrogenic injections of medication can lead to the development of chondromalacia. Chondromalacia occurs in any joint and is especially common in joints that have had trauma and deformities. Cartilage is the soft tissue padding which is present between all joint and bones and acts like a shock absorber. The cartilage experiences a lot of wear, tear and damage over time. The cartilage is essentially avascular (has no blood or nerve supply) and is therefore quite a difficult area to heal. Long term therapy is essential in ensuring healthy repair so that further complications are not experienced in the future.

Keywords

Chondromalacia, Chondromalacia Patella, Knee Pain, Cartilage.

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